Who owns Zymeworks (ZYME)
Which tracked institutional funds hold ZYME, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See ZYME company fundamentals →
Ownership as of the 2026-Q2 13F filings (latest filed 2026-09-22). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
47 tracked funds added or opened ZYME while 47 trimmed or exited it between 2026-Q1 and 2026-Q2 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
ZYME’s largest tracked holder by dollar value, EcoR1 Capital, LLC, sizes it at 29.8% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 29.8pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in ZYME divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2026-Q1 and 2026-Q2, across 196 tracked filers holding ZYME, 85 increased or opened the position and 112 reduced or closed it; over the same quarter, there were no open-market insider Form 4s.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in ZYME between the 2026-Q1 and 2026-Q2 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 7
- NOMURA ASSET MANAGEMENT INTERNATIONAL INC.$23M
- FIRST TRUST ADVISORS LP$9M
- Y-Intercept (Hong Kong) Ltd$2M
- LMR Partners LLP$2M
- TWO SIGMA INVESTMENTS, LP$2M
- Brevan Howard Capital Management LP$678K
Full exits 17
- MPM BIOIMPACT LLC$14M
- ROYCE & ASSOCIATES LP$7M
- HRT FINANCIAL LP$6M
- NORGES BANK$2M
- AMERICAN CENTURY COMPANIES INC$2M
- MILLENNIUM MANAGEMENT LLC$1M
Largest adds
- EcoR1 Capital, LLC$25M
- PERCEPTIVE ADVISORS LLC$21M
- Assenagon Asset Management S.A.$14M
- Rubric Capital Management LP$8M
- Pictet Asset Management Holding SA$7M
- Prosight Management, LP$4M
Largest trims
- Nuveen, LLC$13M
- DEUTSCHE BANK AG\$13M
- Capricorn Fund Managers Ltd$13M
- ARROWSTREET CAPITAL, LIMITED PARTNERSHIP$8M
- UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC$6M
- JANE STREET GROUP, LLC$5M
Institutional holders
One row per tracked fund, most shares held first (every row is from one quarter; reported value breaks ties). “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding.
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| EcoR1 Capital, LLC | 22,970,388 | $600M | 34.0% | 2026-Q2 |
| Rubric Capital Management LP | 7,000,000 | $183M | 10.4% | 2026-Q2 |
| BlackRock, Inc. trimmed | 4,251,030 | $111M | 6.3% | 2026-Q2 |
| PERCEPTIVE ADVISORS LLC added | 4,182,953 | $109M | 6.2% | 2026-Q2 |
| BVF INC/IL trimmed | 3,649,142 | $95M | 5.4% | 2026-Q2 |
| MORGAN STANLEY trimmed | 2,231,260 | $58M | 3.3% | 2026-Q2 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. trimmed | 1,781,116 | $47M | 2.6% | 2026-Q2 |
| VANGUARD CAPITAL MANAGEMENT LLC trimmed | 1,558,998 | $41M | 2.3% | 2026-Q2 |
| Assenagon Asset Management S.A. added | 1,252,027 | $33M | 1.9% | 2026-Q2 |
| Nextech Invest Ltd. | 1,113,946 | $29M | 1.7% | 2026-Q2 |
| STATE STREET CORP added | 1,088,216 | $28M | 1.6% | 2026-Q2 |
| DIMENSIONAL FUND ADVISORS LP trimmed | 994,955 | $26M | 1.5% | 2026-Q2 |
| CITADEL ADVISORS LLC trimmed | 914,136 | $24M | 1.4% | 2026-Q2 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. new | 889,802 | $23M | 1.3% | 2026-Q2 |
| FMR LLC added | 702,568 | $18M | 1.0% | 2026-Q2 |
| GEODE CAPITAL MANAGEMENT, LLC added | 692,410 | $18M | 1.0% | 2026-Q2 |
| Prosight Management, LP added | 674,434 | $18M | 1.0% | 2026-Q2 |
| Qube Research & Technologies Ltd added | 593,590 | $16M | 0.9% | 2026-Q2 |
| VANGUARD PORTFOLIO MANAGEMENT LLC added | 510,032 | $13M | 0.8% | 2026-Q2 |
| Redmile Group, LLC | 491,654 | $13M | 0.7% | 2026-Q2 |
| Capricorn Fund Managers Ltd trimmed | 486,529 | $13M | 0.7% | 2026-Q2 |
| GOLDMAN SACHS GROUP INC trimmed | 470,822 | $12M | 0.7% | 2026-Q2 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP trimmed | 418,497 | $11M | 0.6% | 2026-Q2 |
| DEUTSCHE BANK AG\ trimmed | 397,190 | $10M | 0.6% | 2026-Q2 |
| Hillsdale Investment Management Inc. added | 382,922 | $10M | 0.6% | 2026-Q2 |
| FIRST TRUST ADVISORS LP new | 340,363 | $9M | 0.5% | 2026-Q2 |
| Granahan Investment Management, LLC added | 336,157 | $9M | 0.5% | 2026-Q2 |
| NORTHERN TRUST CORP added | 321,073 | $8M | 0.5% | 2026-Q2 |
| Pictet Asset Management Holding SA added | 308,187 | $7M | 0.4% | 2026-Q2 |
| PICTON MAHONEY ASSET MANAGEMENT added | 271,343 | $7M | 0.4% | 2026-Q2 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC added | 223,766 | $6M | 0.3% | 2026-Q2 |
| BANK OF AMERICA CORP /DE/ trimmed | 219,071 | $6M | 0.3% | 2026-Q2 |
| WELLS FARGO & COMPANY/MN added | 217,199 | $6M | 0.3% | 2026-Q2 |
| SummitTX Capital, L.P. trimmed | 210,802 | $6M | 0.3% | 2026-Q2 |
| Man Group plc added | 210,779 | $6M | 0.3% | 2026-Q2 |
| FEDERATED HERMES, INC. added | 187,995 | $5M | 0.3% | 2026-Q2 |
| RAYMOND JAMES FINANCIAL INC trimmed | 166,416 | $4M | 0.2% | 2026-Q2 |
| STATE OF WISCONSIN INVESTMENT BOARD added | 155,579 | $4M | 0.2% | 2026-Q2 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC trimmed | 152,416 | $4M | 0.2% | 2026-Q2 |
| KENNEDY CAPITAL MANAGEMENT LLC trimmed | 145,386 | $4M | 0.2% | 2026-Q2 |
| D. E. Shaw & Co., Inc. trimmed | 144,807 | $4M | 0.2% | 2026-Q2 |
| DIADEMA PARTNERS LP | 142,132 | $4M | 0.2% | 2026-Q2 |
| CITIGROUP INC added | 131,441 | $3M | 0.2% | 2026-Q2 |
| Bank of New York Mellon Corp added | 131,106 | $3M | 0.2% | 2026-Q2 |
| XTX Topco Ltd trimmed | 125,877 | $3M | 0.2% | 2026-Q2 |
| Nuveen, LLC trimmed | 119,389 | $3M | 0.2% | 2026-Q2 |
| PANAGORA ASSET MANAGEMENT INC trimmed | 118,603 | $3M | 0.2% | 2026-Q2 |
| UBS Group AG trimmed | 115,095 | $3M | 0.2% | 2026-Q2 |
| Invesco Ltd. trimmed | 112,212 | $3M | 0.2% | 2026-Q2 |
| AQR CAPITAL MANAGEMENT LLC added | 111,282 | $3M | 0.2% | 2026-Q2 |
| WELLINGTON MANAGEMENT GROUP LLP added | 110,014 | $3M | 0.2% | 2026-Q2 |
| JPMORGAN CHASE & CO trimmed | 106,398 | $3M | 0.1% | 2026-Q2 |
| Tema ETFs LLC added | 105,615 | $3M | 0.2% | 2026-Q2 |
| Tidal Investments LLC added | 105,615 | $3M | 0.2% | 2026-Q2 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 105,184 | $3M | 0.2% | 2026-Q2 |
| Manatuck Hill Partners, LLC added | 100,000 | $3M | 0.1% | 2026-Q2 |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 88,800 | $2M | 0.1% | 2026-Q2 |
| MACKENZIE FINANCIAL CORP added | 87,745 | $2M | 0.1% | 2026-Q2 |
| PRINCIPAL FINANCIAL GROUP INC added | 84,990 | $2M | 0.1% | 2026-Q2 |
| Y-Intercept (Hong Kong) Ltd added | 83,455 | $2M | 0.1% | 2026-Q2 |
| LMR Partners LLP new | 82,500 | $2M | 0.1% | 2026-Q2 |
| AMERIPRISE FINANCIAL INC added | 82,264 | $2M | 0.1% | 2026-Q2 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC trimmed | 81,359 | $2M | 0.1% | 2026-Q2 |
| VANGUARD FIDUCIARY TRUST CO trimmed | 80,120 | $2M | 0.1% | 2026-Q2 |
| STIFEL FINANCIAL CORP added | 77,214 | $2M | 0.1% | 2026-Q2 |
| FRANKLIN RESOURCES INC trimmed | 76,528 | $2M | 0.1% | 2026-Q2 |
| RHUMBLINE ADVISERS trimmed | 75,066 | $2M | 0.1% | 2026-Q2 |
| Swiss National Bank | 74,200 | $2M | 0.1% | 2026-Q2 |
| MARTINGALE ASSET MANAGEMENT L P added | 73,282 | $2M | 0.1% | 2026-Q2 |
| TWO SIGMA INVESTMENTS, LP new | 71,874 | $2M | 0.1% | 2026-Q2 |
| Dana Investment Advisors, Inc. added | 71,660 | $2M | 0.1% | 2026-Q2 |
| CREDIT AGRICOLE S A trimmed | 71,000 | $2M | 0.1% | 2026-Q2 |
| Fisher Asset Management, LLC trimmed | 70,775 | $2M | 0.1% | 2026-Q2 |
| SEGALL BRYANT & HAMILL, LLC added | 66,836 | $2M | 0.1% | 2026-Q2 |
| Verdad Advisers, LP trimmed | 66,688 | $2M | 0.1% | 2026-Q2 |
| Susquehanna Portfolio Strategies, LLC trimmed | 65,248 | $2M | 0.1% | 2026-Q2 |
| Campbell & CO Investment Adviser LLC added | 60,874 | $2M | 0.1% | 2026-Q2 |
| ROYAL BANK OF CANADA added | 56,278 | $1M | 0.1% | 2026-Q2 |
| ALLIANCEBERNSTEIN L.P. | 55,896 | $1M | 0.1% | 2026-Q2 |
| Virtus Investment Advisers, LLC added | 50,825 | $1M | 0.1% | 2026-Q2 |
| ENVESTNET ASSET MANAGEMENT INC added | 48,675 | $1M | 0.1% | 2026-Q2 |
| Russell Investments Group, Ltd. added | 47,867 | $1M | 0.1% | 2026-Q2 |
| Quantinno Capital Management LP added | 47,642 | $1M | 0.1% | 2026-Q2 |
| Legal & General Group Plc added | 43,160 | $1M | 0.1% | 2026-Q2 |
| VICTORY CAPITAL MANAGEMENT INC added | 42,524 | $1M | 0.1% | 2026-Q2 |
| MARSHALL WACE, LLP added | 40,948 | $1M | 0.1% | 2026-Q2 |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC added | 39,534 | $1M | 0.1% | 2026-Q2 |
| PRICE T ROWE ASSOCIATES INC /MD/ added | 38,486 | $1M | 0.1% | 2026-Q2 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM added | 37,744 | $987K | 0.1% | 2026-Q2 |
| JACOBS LEVY EQUITY MANAGEMENT, INC trimmed | 36,922 | $965K | 0.1% | 2026-Q2 |
| TUDOR INVESTMENT CORP ET AL trimmed | 36,471 | $953K | 0.1% | 2026-Q2 |
| Persistent Asset Partners Ltd | 35,935 | $939K | 0.1% | 2026-Q2 |
| HighVista Strategies LLC trimmed | 34,013 | $889K | 0.1% | 2026-Q2 |
| COMMONWEALTH EQUITY SERVICES, LLC added | 32,052 | $838K | 0.0% | 2026-Q2 |
| SBI Okasan Asset Management Co.Ltd. | 32,000 | $771K | 0.0% | 2026-Q2 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE trimmed | 30,886 | $807K | 0.0% | 2026-Q2 |
| Creative Planning trimmed | 29,731 | $777K | 0.0% | 2026-Q2 |
| MetLife Investment Management, LLC trimmed | 27,884 | $729K | 0.0% | 2026-Q2 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ added | 27,670 | $723K | 0.0% | 2026-Q2 |
| STRS OHIO trimmed | 26,500 | $693K | 0.0% | 2026-Q2 |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.