Who owns TYRA (TYRA)
Which tracked institutional funds hold TYRA, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See TYRA company fundamentals →
Ownership as of the 2026-Q1 13F filings. 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
The tracked-fund tape on TYRA is one-sided between 2025-Q4 and 2026-Q1: 87 added or opened and 20 trimmed or exited — on balance accumulating.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
TYRA’s largest tracked holder by dollar value, RA CAPITAL MANAGEMENT, L.P., sizes it at 5.0% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 4.9pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in TYRA divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2025-Q4 and 2026-Q1, across 164 tracked filers holding TYRA, 105 increased or opened the position and 50 reduced or closed it; over the same quarter, open-market insider Form 4 buying and selling roughly offset.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in TYRA between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 25
- Paradigm Biocapital Advisors LP$79M
- VANGUARD CAPITAL MANAGEMENT LLC$43M
- JENNISON ASSOCIATES LLC$24M
- DEERFIELD MANAGEMENT COMPANY, L.P.$21M
- Woodline Partners LP$12M
- Affinity Asset Advisors, LLC$10M
Full exits 8
- Kynam Capital Management, LP$41M
- VANGUARD GROUP INC$37M
- Trails Edge Capital Partners, LP$18M
- BOONE CAPITAL MANAGEMENT LLC$10M
- INVESTMENT COUNSEL CO OF NEVADA$2M
- TWO SIGMA ADVISERS, LP$2M
Largest adds
- FMR LLC$288M
- RA CAPITAL MANAGEMENT, L.P.$147M
- FARALLON CAPITAL MANAGEMENT LLC$83M
- JANUS HENDERSON GROUP PLC$72M
- Nextech Invest, Ltd.$49M
- TCG Crossover Management, LLC$48M
Largest trims
- Vestal Point Capital, LP$62M
- Canaan Partners XI LLC$60M
- Point72 Asset Management, L.P.$21M
- MARSHALL WACE, LLP$11M
- BALYASNY ASSET MANAGEMENT L.P.$8M
- Eversept Partners, LP$6M
Institutional holders
One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 12,198,625 | $467M | 17.8% | 2026-Q1 |
| FMR LLC added | 7,521,874 | $288M | 11.0% | 2026-Q1 |
| Nextech Invest, Ltd. | 4,055,861 | $155M | 5.9% | 2026-Q1 |
| JANUS HENDERSON GROUP PLC added | 3,890,589 | $149M | 5.7% | 2026-Q1 |
| Alta Partners Management Company, L.P. | 3,823,425 | $146M | 5.6% | 2026-Q1 |
| FARALLON CAPITAL MANAGEMENT LLC added | 3,580,818 | $137M | 5.2% | 2026-Q1 |
| TCG Crossover Management, LLC added | 3,248,980 | $124M | 4.7% | 2026-Q1 |
| Commodore Capital LP trimmed | 2,475,000 | $95M | 3.6% | 2026-Q1 |
| BlackRock, Inc. added | 2,217,929 | $85M | 3.2% | 2026-Q1 |
| Paradigm Biocapital Advisors LP new | 2,054,991 | $79M | 3.0% | 2026-Q1 |
| BVF INC/IL trimmed | 1,976,196 | $76M | 2.9% | 2026-Q1 |
| Caligan Partners LP added | 1,276,968 | $49M | 1.9% | 2026-Q1 |
| STATE STREET CORP added | 1,216,078 | $47M | 1.8% | 2026-Q1 |
| VANGUARD CAPITAL MANAGEMENT LLC new | 1,125,970 | $43M | 1.6% | 2026-Q1 |
| 5AM Venture Management, LLC | 1,029,298 | $39M | 1.5% | 2026-Q1 |
| PRICE T ROWE ASSOCIATES INC /MD/ added | 986,061 | $38M | 1.4% | 2026-Q1 |
| Logos Global Management LP added | 850,000 | $33M | 1.2% | 2026-Q1 |
| BARCLAYS PLC added | 833,399 | $32M | 1.2% | 2026-Q1 |
| Canaan Partners XI LLC trimmed | 750,000 | $29M | 1.1% | 2026-Q1 |
| GEODE CAPITAL MANAGEMENT, LLC added | 658,482 | $25M | 1.0% | 2026-Q1 |
| JENNISON ASSOCIATES LLC added | 632,432 | $24M | 0.9% | 2026-Q1 |
| Sio Capital Management, LLC added | 605,439 | $23M | 0.9% | 2026-Q1 |
| GOLDMAN SACHS GROUP INC added | 550,334 | $21M | 0.8% | 2026-Q1 |
| DEERFIELD MANAGEMENT COMPANY, L.P. trimmed | 549,000 | $21M | 0.8% | 2026-Q1 |
| BALYASNY ASSET MANAGEMENT L.P. trimmed | 351,479 | $13M | 0.5% | 2026-Q1 |
| Elmind Capital, LP | 350,000 | $13M | 0.5% | 2026-Q1 |
| Woodline Partners LP added | 301,040 | $12M | 0.4% | 2026-Q1 |
| BOOTHBAY FUND MANAGEMENT, LLC added | 273,274 | $10M | 0.4% | 2026-Q1 |
| Affinity Asset Advisors, LLC new | 257,512 | $10M | 0.4% | 2026-Q1 |
| VANGUARD PORTFOLIO MANAGEMENT LLC new | 247,270 | $9M | 0.4% | 2026-Q1 |
| RAYMOND JAMES FINANCIAL INC added | 247,098 | $9M | 0.4% | 2026-Q1 |
| MILLENNIUM MANAGEMENT LLC added | 221,581 | $8M | 0.3% | 2026-Q1 |
| NORTHERN TRUST CORP added | 218,508 | $8M | 0.3% | 2026-Q1 |
| BANK OF AMERICA CORP /DE/ added | 209,922 | $8M | 0.3% | 2026-Q1 |
| Sofinnova Investments, Inc. new | 204,015 | $8M | 0.3% | 2026-Q1 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC trimmed | 199,111 | $8M | 0.3% | 2026-Q1 |
| MARSHALL WACE, LLP trimmed | 196,472 | $8M | 0.3% | 2026-Q1 |
| STEMPOINT CAPITAL LP new | 193,177 | $7M | 0.3% | 2026-Q1 |
| BNP PARIBAS FINANCIAL MARKETS added | 190,039 | $7M | 0.3% | 2026-Q1 |
| ALGERT GLOBAL LLC added | 188,010 | $7M | 0.3% | 2026-Q1 |
| JACOBS LEVY EQUITY MANAGEMENT, INC added | 162,204 | $6M | 0.2% | 2026-Q1 |
| VANGUARD FIDUCIARY TRUST CO new | 157,791 | $6M | 0.2% | 2026-Q1 |
| Trexquant Investment LP added | 147,317 | $6M | 0.2% | 2026-Q1 |
| AMERIPRISE FINANCIAL INC added | 144,900 | $6M | 0.2% | 2026-Q1 |
| HighVista Strategies LLC added | 131,304 | $5M | 0.2% | 2026-Q1 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. trimmed | 128,860 | $5M | 0.2% | 2026-Q1 |
| MORGAN STANLEY added | 120,485 | $5M | 0.2% | 2026-Q1 |
| Invesco Ltd. trimmed | 109,052 | $4M | 0.2% | 2026-Q1 |
| TWO SIGMA INVESTMENTS, LP trimmed | 101,618 | $4M | 0.1% | 2026-Q1 |
| DIMENSIONAL FUND ADVISORS LP trimmed | 91,826 | $4M | 0.1% | 2026-Q1 |
| OPPENHEIMER & CO INC trimmed | 84,192 | $3M | 0.1% | 2026-Q1 |
| XTX Topco Ltd added | 83,896 | $3M | 0.1% | 2026-Q1 |
| Schonfeld Strategic Advisors LLC new | 79,592 | $3M | 0.1% | 2026-Q1 |
| Cinctive Capital Management LP added | 78,018 | $3M | 0.1% | 2026-Q1 |
| Kalehua Capital Management LLC | 74,465 | $3M | 0.1% | 2026-Q1 |
| Ensign Peak Advisors, Inc trimmed | 74,064 | $3M | 0.1% | 2026-Q1 |
| Bank of New York Mellon Corp added | 72,213 | $3M | 0.1% | 2026-Q1 |
| Russell Investments Group, Ltd. added | 70,422 | $3M | 0.1% | 2026-Q1 |
| Catalio Capital Management, LP new | 67,285 | $3M | 0.1% | 2026-Q1 |
| UBS Group AG added | 61,561 | $2M | 0.1% | 2026-Q1 |
| JPMORGAN CHASE & CO trimmed | 66,789 | $2M | 0.1% | 2026-Q1 |
| Vestal Point Capital, LP trimmed | 54,000 | $2M | 0.1% | 2026-Q1 |
| Nuveen, LLC added | 50,840 | $2M | 0.1% | 2026-Q1 |
| TD Asset Management Inc new | 50,000 | $2M | 0.1% | 2026-Q1 |
| WELLINGTON MANAGEMENT GROUP LLP trimmed | 49,879 | $2M | 0.1% | 2026-Q1 |
| AMERICAN CENTURY COMPANIES INC added | 47,929 | $2M | 0.1% | 2026-Q1 |
| Arkadios Wealth Advisors new | 47,567 | $2M | 0.1% | 2026-Q1 |
| Susquehanna Portfolio Strategies, LLC trimmed | 47,025 | $2M | 0.1% | 2026-Q1 |
| ALPS ADVISORS INC added | 43,856 | $2M | 0.1% | 2026-Q1 |
| PDT Partners, LLC | 42,284 | $2M | 0.1% | 2026-Q1 |
| Jump Financial, LLC trimmed | 41,375 | $2M | 0.1% | 2026-Q1 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE added | 40,224 | $2M | 0.1% | 2026-Q1 |
| RHUMBLINE ADVISERS added | 39,660 | $2M | 0.1% | 2026-Q1 |
| Point72 Asset Management, L.P. trimmed | 38,850 | $1M | 0.1% | 2026-Q1 |
| VOYA INVESTMENT MANAGEMENT LLC added | 38,358 | $1M | 0.1% | 2026-Q1 |
| Brevan Howard Capital Management LP added | 38,606 | $1M | 0.1% | 2026-Q1 |
| Rafferty Asset Management, LLC added | 34,856 | $1M | 0.1% | 2026-Q1 |
| STATE OF WISCONSIN INVESTMENT BOARD trimmed | 33,258 | $1M | 0.0% | 2026-Q1 |
| Fisher Asset Management, LLC | 28,800 | $1M | 0.0% | 2026-Q1 |
| AQR CAPITAL MANAGEMENT LLC added | 28,709 | $1M | 0.0% | 2026-Q1 |
| Eversept Partners, LP trimmed | 27,055 | $1M | 0.0% | 2026-Q1 |
| Swiss National Bank trimmed | 26,400 | $1M | 0.0% | 2026-Q1 |
| Creative Planning added | 23,948 | $917K | 0.0% | 2026-Q1 |
| ALLIANCEBERNSTEIN L.P. | 31,990 | $841K | 0.0% | 2026-Q1 |
| Auour Investments LLC | 21,020 | $805K | 0.0% | 2026-Q1 |
| Kynam Capital Management, LP trimmed | 1,564,492 | $41M | 1.6% | 2025-Q4 stale |
| VANGUARD GROUP INC trimmed | 1,405,024 | $37M | 1.4% | 2025-Q4 stale |
| Trails Edge Capital Partners, LP new | 700,000 | $18M | 0.7% | 2025-Q4 stale |
| BOONE CAPITAL MANAGEMENT LLC new | 398,482 | $10M | 0.4% | 2025-Q4 stale |
| ORBIMED ADVISORS LLC trimmed | 804,603 | $8M | 0.3% | 2025-Q2 stale |
| Pictet Asset Management Holding SA added | 459,113 | $4M | 0.2% | 2025-Q1 stale |
| RENAISSANCE TECHNOLOGIES LLC added | 170,100 | $2M | 0.1% | 2025-Q3 stale |
| INVESTMENT COUNSEL CO OF NEVADA | 85,020 | $2M | 0.1% | 2025-Q4 stale |
| AXA Investment Managers S.A. new | 128,789 | $2M | 0.1% | 2025-Q3 stale |
| TWO SIGMA ADVISERS, LP trimmed | 58,900 | $2M | 0.1% | 2025-Q4 stale |
| SUPERSTRING CAPITAL MANAGEMENT LP new | 58,677 | $2M | 0.1% | 2025-Q4 stale |
| Polar Asset Management Partners Inc. added | 141,241 | $1M | 0.1% | 2025-Q1 stale |
| AXA S.A. added | 128,400 | $1M | 0.0% | 2025-Q2 stale |
| Y-Intercept (Hong Kong) Ltd new | 45,942 | $1M | 0.0% | 2025-Q4 stale |
| Ally Bridge Group (NY) LLC trimmed | 107,244 | $997K | 0.0% | 2025-Q1 stale |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.