Who owns Tyra Biosciences (TYRA)
Which tracked institutional funds hold TYRA, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See TYRA company fundamentals →
Ownership as of the 2026-Q2 13F filings (latest filed 2026-09-22). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
55 tracked funds added or opened TYRA while 53 trimmed or exited it between 2026-Q1 and 2026-Q2 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
TYRA’s largest tracked holder by dollar value, RA CAPITAL MANAGEMENT, L.P., sizes it at 3.4% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 3.4pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in TYRA divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2026-Q1 and 2026-Q2, across 165 tracked filers holding TYRA, 103 increased or opened the position and 71 reduced or closed it; over the same quarter, there were no open-market insider Form 4s.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in TYRA between the 2026-Q1 and 2026-Q2 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 15
- Jupiter Topco LLC$139M
- Hood River Capital Management LLC$32M
- Siren, L.L.C.$23M
- Defilade Capital Management, L.P.$12M
- Qube Research & Technologies Ltd$9M
- ADAGE CAPITAL PARTNERS GP, L.L.C.$5M
Full exits 16
- JANUS HENDERSON GROUP PLC$149M
- FARALLON CAPITAL MANAGEMENT LLC$137M
- Logos Global Management LP$33M
- BALYASNY ASSET MANAGEMENT L.P.$13M
- Seven Fleet Capital Management LP$8M
- Schonfeld Strategic Advisors LLC$3M
Largest adds
- PRICE T ROWE ASSOCIATES INC /MD/$51M
- STATE STREET CORP$22M
- STEMPOINT CAPITAL LP$13M
- BlackRock, Inc.$12M
- DEERFIELD MANAGEMENT COMPANY, L.P.$11M
- MARSHALL WACE, LLP$11M
Largest trims
- RA CAPITAL MANAGEMENT, L.P.$78M
- Nextech Invest Ltd.$42M
- Commodore Capital LP$35M
- BARCLAYS PLC$31M
- BVF INC/IL$29M
- Alta Partners Management Company, L.P.$24M
Institutional holders
One row per tracked fund, most shares held first (every row is from one quarter; reported value breaks ties). “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding.
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 12,198,625 | $390M | 17.7% | 2026-Q2 |
| FMR LLC added | 8,920,513 | $285M | 12.9% | 2026-Q2 |
| Jupiter Topco LLC new | 4,352,448 | $139M | 6.3% | 2026-Q2 |
| Alta Partners Management Company, L.P. | 3,823,425 | $122M | 5.5% | 2026-Q2 |
| Nextech Invest Ltd. trimmed | 3,553,585 | $114M | 5.2% | 2026-Q2 |
| TCG Crossover Management, LLC | 3,248,980 | $104M | 4.7% | 2026-Q2 |
| BlackRock, Inc. added | 3,031,972 | $97M | 4.4% | 2026-Q2 |
| PRICE T ROWE ASSOCIATES INC /MD/ added | 2,782,567 | $89M | 4.0% | 2026-Q2 |
| STATE STREET CORP added | 2,140,368 | $68M | 3.1% | 2026-Q2 |
| Commodore Capital LP trimmed | 1,875,000 | $60M | 2.7% | 2026-Q2 |
| Paradigm Biocapital Advisors LP trimmed | 1,828,607 | $58M | 2.7% | 2026-Q2 |
| VANGUARD CAPITAL MANAGEMENT LLC added | 1,508,447 | $48M | 2.2% | 2026-Q2 |
| BVF INC/IL trimmed | 1,476,196 | $47M | 2.1% | 2026-Q2 |
| 5AM Venture Management, LLC | 1,029,298 | $33M | 1.5% | 2026-Q2 |
| DEERFIELD MANAGEMENT COMPANY, L.P. added | 1,017,000 | $32M | 1.5% | 2026-Q2 |
| Hood River Capital Management LLC new | 1,016,775 | $32M | 1.5% | 2026-Q2 |
| GEODE CAPITAL MANAGEMENT, LLC added | 970,734 | $31M | 1.4% | 2026-Q2 |
| Caligan Partners LP trimmed | 806,986 | $26M | 1.2% | 2026-Q2 |
| Canaan Partners XI LLC | 750,000 | $24M | 1.1% | 2026-Q2 |
| Siren, L.L.C. new | 725,000 | $23M | 1.1% | 2026-Q2 |
| Sio Capital Management, LLC added | 695,315 | $22M | 1.0% | 2026-Q2 |
| STEMPOINT CAPITAL LP added | 632,754 | $20M | 0.9% | 2026-Q2 |
| MARSHALL WACE, LLP added | 583,133 | $19M | 0.8% | 2026-Q2 |
| GOLDMAN SACHS GROUP INC trimmed | 463,477 | $15M | 0.7% | 2026-Q2 |
| JENNISON ASSOCIATES LLC trimmed | 450,964 | $14M | 0.7% | 2026-Q2 |
| TWO SIGMA INVESTMENTS, LP added | 449,808 | $14M | 0.7% | 2026-Q2 |
| VANGUARD PORTFOLIO MANAGEMENT LLC added | 403,019 | $13M | 0.6% | 2026-Q2 |
| Defilade Capital Management, L.P. new | 376,870 | $12M | 0.5% | 2026-Q2 |
| BANK OF AMERICA CORP /DE/ added | 349,732 | $11M | 0.5% | 2026-Q2 |
| Walleye Capital LLC added | 347,898 | $11M | 0.5% | 2026-Q2 |
| Woodline Partners LP added | 320,040 | $10M | 0.5% | 2026-Q2 |
| NORTHERN TRUST CORP added | 310,084 | $10M | 0.5% | 2026-Q2 |
| MORGAN STANLEY added | 300,322 | $10M | 0.4% | 2026-Q2 |
| CITADEL ADVISORS LLC added | 278,307 | $9M | 0.4% | 2026-Q2 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC added | 267,699 | $9M | 0.4% | 2026-Q2 |
| Qube Research & Technologies Ltd new | 266,934 | $9M | 0.4% | 2026-Q2 |
| BNP PARIBAS FINANCIAL MARKETS added | 240,227 | $8M | 0.3% | 2026-Q2 |
| ALGERT GLOBAL LLC added | 239,120 | $8M | 0.3% | 2026-Q2 |
| VANGUARD FIDUCIARY TRUST CO added | 224,805 | $7M | 0.3% | 2026-Q2 |
| DIMENSIONAL FUND ADVISORS LP added | 217,078 | $7M | 0.3% | 2026-Q2 |
| Affinity Asset Advisors, LLC trimmed | 200,012 | $6M | 0.3% | 2026-Q2 |
| FRANKLIN RESOURCES INC added | 192,340 | $6M | 0.3% | 2026-Q2 |
| HighVista Strategies LLC added | 184,774 | $6M | 0.3% | 2026-Q2 |
| RAYMOND JAMES FINANCIAL INC trimmed | 180,881 | $6M | 0.3% | 2026-Q2 |
| JPMORGAN CHASE & CO added | 178,263 | $6M | 0.3% | 2026-Q2 |
| MILLENNIUM MANAGEMENT LLC trimmed | 177,672 | $6M | 0.3% | 2026-Q2 |
| BOOTHBAY FUND MANAGEMENT, LLC trimmed | 173,559 | $6M | 0.3% | 2026-Q2 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. trimmed | 162,000 | $5M | 0.2% | 2026-Q2 |
| Jump Financial, LLC added | 157,000 | $5M | 0.2% | 2026-Q2 |
| VICTORY CAPITAL MANAGEMENT INC added | 152,585 | $5M | 0.2% | 2026-Q2 |
| Ensign Peak Advisors, Inc added | 146,537 | $5M | 0.2% | 2026-Q2 |
| Trexquant Investment LP trimmed | 132,740 | $4M | 0.2% | 2026-Q2 |
| UBS Group AG added | 129,945 | $4M | 0.2% | 2026-Q2 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. trimmed | 123,420 | $4M | 0.2% | 2026-Q2 |
| Bank of New York Mellon Corp added | 103,720 | $3M | 0.2% | 2026-Q2 |
| Russell Investments Group, Ltd. added | 102,703 | $3M | 0.1% | 2026-Q2 |
| ORBIMED ADVISORS LLC trimmed | 102,000 | $3M | 0.1% | 2026-Q2 |
| JACOBS LEVY EQUITY MANAGEMENT, INC trimmed | 89,205 | $3M | 0.1% | 2026-Q2 |
| OPPENHEIMER & CO INC trimmed | 83,783 | $3M | 0.1% | 2026-Q2 |
| XTX Topco Ltd trimmed | 81,320 | $3M | 0.1% | 2026-Q2 |
| Nuveen, LLC added | 78,829 | $3M | 0.1% | 2026-Q2 |
| Kalehua Capital Management LLC | 74,465 | $2M | 0.1% | 2026-Q2 |
| SEI INVESTMENTS CO new | 66,607 | $2M | 0.1% | 2026-Q2 |
| Squarepoint Ops LLC added | 63,805 | $2M | 0.1% | 2026-Q2 |
| CITIGROUP INC added | 62,279 | $2M | 0.1% | 2026-Q2 |
| Fisher Asset Management, LLC added | 60,230 | $2M | 0.1% | 2026-Q2 |
| ALPS ADVISORS INC added | 60,159 | $2M | 0.1% | 2026-Q2 |
| WELLINGTON MANAGEMENT GROUP LLP added | 59,601 | $2M | 0.1% | 2026-Q2 |
| RHUMBLINE ADVISERS added | 52,039 | $2M | 0.1% | 2026-Q2 |
| TD Asset Management Inc | 50,000 | $2M | 0.1% | 2026-Q2 |
| Arkadios Wealth Advisors added | 49,336 | $2M | 0.1% | 2026-Q2 |
| ALLIANCEBERNSTEIN L.P. added | 48,420 | $2M | 0.1% | 2026-Q2 |
| STATE OF WISCONSIN INVESTMENT BOARD added | 46,697 | $1M | 0.1% | 2026-Q2 |
| Susquehanna Portfolio Strategies, LLC trimmed | 44,878 | $1M | 0.1% | 2026-Q2 |
| Swiss National Bank added | 44,700 | $1M | 0.1% | 2026-Q2 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE added | 44,327 | $1M | 0.1% | 2026-Q2 |
| ExodusPoint Capital Management, LP added | 41,026 | $1M | 0.1% | 2026-Q2 |
| Rafferty Asset Management, LLC added | 38,702 | $1M | 0.1% | 2026-Q2 |
| DEUTSCHE BANK AG\ added | 36,935 | $1M | 0.1% | 2026-Q2 |
| Verdad Advisers, LP new | 36,003 | $1M | 0.1% | 2026-Q2 |
| WELLS FARGO & COMPANY/MN added | 33,561 | $1M | 0.0% | 2026-Q2 |
| Sofinnova Investments, Inc. trimmed | 32,267 | $1M | 0.0% | 2026-Q2 |
| Engineers Gate Manager LP new | 31,958 | $1M | 0.0% | 2026-Q2 |
| AQR CAPITAL MANAGEMENT LLC added | 29,853 | $954K | 0.0% | 2026-Q2 |
| Tema ETFs LLC new | 29,519 | $943K | 0.0% | 2026-Q2 |
| Tidal Investments LLC new | 29,519 | $943K | 0.0% | 2026-Q2 |
| PDT Partners, LLC trimmed | 25,684 | $820K | 0.0% | 2026-Q2 |
| Invesco Ltd. trimmed | 24,893 | $795K | 0.0% | 2026-Q2 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM added | 24,544 | $784K | 0.0% | 2026-Q2 |
| STRS OHIO added | 22,100 | $706K | 0.0% | 2026-Q2 |
| Creative Planning trimmed | 21,803 | $696K | 0.0% | 2026-Q2 |
| MetLife Investment Management, LLC added | 21,723 | $694K | 0.0% | 2026-Q2 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. added | 21,364 | $683K | 0.0% | 2026-Q2 |
| LMR Partners LLP new | 21,151 | $676K | 0.0% | 2026-Q2 |
| Auour Investments LLC | 21,020 | $671K | 0.0% | 2026-Q2 |
| VOYA INVESTMENT MANAGEMENT LLC trimmed | 20,282 | $648K | 0.0% | 2026-Q2 |
| BARCLAYS PLC trimmed | 20,275 | $648K | 0.0% | 2026-Q2 |
| D. E. Shaw & Co., Inc. trimmed | 20,189 | $645K | 0.0% | 2026-Q2 |
| Vanguard Global Advisers, LLC added | 20,154 | $644K | 0.0% | 2026-Q2 |
| Elmind Capital, LP trimmed | 20,000 | $639K | 0.0% | 2026-Q2 |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.