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Institutional Ownership · SEC Form 13F

Who owns Tyra Biosciences (TYRA)


Which tracked institutional funds hold TYRA, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See TYRA company fundamentals →

Ownership as of the 2026-Q2 13F filings (latest filed 2026-09-22). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.

165
Institutional holders
69M
Shares held (tracked funds)

How the tape is positioned

55 tracked funds added or opened TYRA while 53 trimmed or exited it between 2026-Q1 and 2026-Q2 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.

A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.

Conviction spread

TYRA’s largest tracked holder by dollar value, RA CAPITAL MANAGEMENT, L.P., sizes it at 3.4% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 3.4pp conviction gap — its largest holder concentrates the name more heavily than the typical one.

Book-share is each fund’s reported value in TYRA divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.

Institutional & insider positioning

Between 2026-Q1 and 2026-Q2, across 165 tracked filers holding TYRA, 103 increased or opened the position and 71 reduced or closed it; over the same quarter, there were no open-market insider Form 4s.

This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.

New buyers & exits

Funds opening or closing a position in TYRA between the 2026-Q1 and 2026-Q2 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.

New buyers 15

  • Jupiter Topco LLC$139M
  • Hood River Capital Management LLC$32M
  • Siren, L.L.C.$23M
  • Defilade Capital Management, L.P.$12M
  • Qube Research & Technologies Ltd$9M
  • ADAGE CAPITAL PARTNERS GP, L.L.C.$5M

Full exits 16

  • JANUS HENDERSON GROUP PLC$149M
  • FARALLON CAPITAL MANAGEMENT LLC$137M
  • Logos Global Management LP$33M
  • BALYASNY ASSET MANAGEMENT L.P.$13M
  • Seven Fleet Capital Management LP$8M
  • Schonfeld Strategic Advisors LLC$3M

Largest adds

  • PRICE T ROWE ASSOCIATES INC /MD/$51M
  • STATE STREET CORP$22M
  • STEMPOINT CAPITAL LP$13M
  • BlackRock, Inc.$12M
  • DEERFIELD MANAGEMENT COMPANY, L.P.$11M
  • MARSHALL WACE, LLP$11M

Largest trims

  • RA CAPITAL MANAGEMENT, L.P.$78M
  • Nextech Invest Ltd.$42M
  • Commodore Capital LP$35M
  • BARCLAYS PLC$31M
  • BVF INC/IL$29M
  • Alta Partners Management Company, L.P.$24M

Institutional holders

One row per tracked fund, most shares held first (every row is from one quarter; reported value breaks ties). “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding.

FundSharesReported value% of valueQuarter
RA CAPITAL MANAGEMENT, L.P.12,198,625$390M17.7%2026-Q2
FMR LLC added8,920,513$285M12.9%2026-Q2
Jupiter Topco LLC new4,352,448$139M6.3%2026-Q2
Alta Partners Management Company, L.P.3,823,425$122M5.5%2026-Q2
Nextech Invest Ltd. trimmed3,553,585$114M5.2%2026-Q2
TCG Crossover Management, LLC3,248,980$104M4.7%2026-Q2
BlackRock, Inc. added3,031,972$97M4.4%2026-Q2
PRICE T ROWE ASSOCIATES INC /MD/ added2,782,567$89M4.0%2026-Q2
STATE STREET CORP added2,140,368$68M3.1%2026-Q2
Commodore Capital LP trimmed1,875,000$60M2.7%2026-Q2
Paradigm Biocapital Advisors LP trimmed1,828,607$58M2.7%2026-Q2
VANGUARD CAPITAL MANAGEMENT LLC added1,508,447$48M2.2%2026-Q2
BVF INC/IL trimmed1,476,196$47M2.1%2026-Q2
5AM Venture Management, LLC1,029,298$33M1.5%2026-Q2
DEERFIELD MANAGEMENT COMPANY, L.P. added1,017,000$32M1.5%2026-Q2
Hood River Capital Management LLC new1,016,775$32M1.5%2026-Q2
GEODE CAPITAL MANAGEMENT, LLC added970,734$31M1.4%2026-Q2
Caligan Partners LP trimmed806,986$26M1.2%2026-Q2
Canaan Partners XI LLC750,000$24M1.1%2026-Q2
Siren, L.L.C. new725,000$23M1.1%2026-Q2
Sio Capital Management, LLC added695,315$22M1.0%2026-Q2
STEMPOINT CAPITAL LP added632,754$20M0.9%2026-Q2
MARSHALL WACE, LLP added583,133$19M0.8%2026-Q2
GOLDMAN SACHS GROUP INC trimmed463,477$15M0.7%2026-Q2
JENNISON ASSOCIATES LLC trimmed450,964$14M0.7%2026-Q2
TWO SIGMA INVESTMENTS, LP added449,808$14M0.7%2026-Q2
VANGUARD PORTFOLIO MANAGEMENT LLC added403,019$13M0.6%2026-Q2
Defilade Capital Management, L.P. new376,870$12M0.5%2026-Q2
BANK OF AMERICA CORP /DE/ added349,732$11M0.5%2026-Q2
Walleye Capital LLC added347,898$11M0.5%2026-Q2
Woodline Partners LP added320,040$10M0.5%2026-Q2
NORTHERN TRUST CORP added310,084$10M0.5%2026-Q2
MORGAN STANLEY added300,322$10M0.4%2026-Q2
CITADEL ADVISORS LLC added278,307$9M0.4%2026-Q2
CHARLES SCHWAB INVESTMENT MANAGEMENT INC added267,699$9M0.4%2026-Q2
Qube Research & Technologies Ltd new266,934$9M0.4%2026-Q2
BNP PARIBAS FINANCIAL MARKETS added240,227$8M0.3%2026-Q2
ALGERT GLOBAL LLC added239,120$8M0.3%2026-Q2
VANGUARD FIDUCIARY TRUST CO added224,805$7M0.3%2026-Q2
DIMENSIONAL FUND ADVISORS LP added217,078$7M0.3%2026-Q2
Affinity Asset Advisors, LLC trimmed200,012$6M0.3%2026-Q2
FRANKLIN RESOURCES INC added192,340$6M0.3%2026-Q2
HighVista Strategies LLC added184,774$6M0.3%2026-Q2
RAYMOND JAMES FINANCIAL INC trimmed180,881$6M0.3%2026-Q2
JPMORGAN CHASE & CO added178,263$6M0.3%2026-Q2
MILLENNIUM MANAGEMENT LLC trimmed177,672$6M0.3%2026-Q2
BOOTHBAY FUND MANAGEMENT, LLC trimmed173,559$6M0.3%2026-Q2
ADAGE CAPITAL PARTNERS GP, L.L.C. trimmed162,000$5M0.2%2026-Q2
Jump Financial, LLC added157,000$5M0.2%2026-Q2
VICTORY CAPITAL MANAGEMENT INC added152,585$5M0.2%2026-Q2
Ensign Peak Advisors, Inc added146,537$5M0.2%2026-Q2
Trexquant Investment LP trimmed132,740$4M0.2%2026-Q2
UBS Group AG added129,945$4M0.2%2026-Q2
BNP PARIBAS ASSET MANAGEMENT Holding S.A. trimmed123,420$4M0.2%2026-Q2
Bank of New York Mellon Corp added103,720$3M0.2%2026-Q2
Russell Investments Group, Ltd. added102,703$3M0.1%2026-Q2
ORBIMED ADVISORS LLC trimmed102,000$3M0.1%2026-Q2
JACOBS LEVY EQUITY MANAGEMENT, INC trimmed89,205$3M0.1%2026-Q2
OPPENHEIMER & CO INC trimmed83,783$3M0.1%2026-Q2
XTX Topco Ltd trimmed81,320$3M0.1%2026-Q2
Nuveen, LLC added78,829$3M0.1%2026-Q2
Kalehua Capital Management LLC74,465$2M0.1%2026-Q2
SEI INVESTMENTS CO new66,607$2M0.1%2026-Q2
Squarepoint Ops LLC added63,805$2M0.1%2026-Q2
CITIGROUP INC added62,279$2M0.1%2026-Q2
Fisher Asset Management, LLC added60,230$2M0.1%2026-Q2
ALPS ADVISORS INC added60,159$2M0.1%2026-Q2
WELLINGTON MANAGEMENT GROUP LLP added59,601$2M0.1%2026-Q2
RHUMBLINE ADVISERS added52,039$2M0.1%2026-Q2
TD Asset Management Inc50,000$2M0.1%2026-Q2
Arkadios Wealth Advisors added49,336$2M0.1%2026-Q2
ALLIANCEBERNSTEIN L.P. added48,420$2M0.1%2026-Q2
STATE OF WISCONSIN INVESTMENT BOARD added46,697$1M0.1%2026-Q2
Susquehanna Portfolio Strategies, LLC trimmed44,878$1M0.1%2026-Q2
Swiss National Bank added44,700$1M0.1%2026-Q2
MANUFACTURERS LIFE INSURANCE COMPANY, THE added44,327$1M0.1%2026-Q2
ExodusPoint Capital Management, LP added41,026$1M0.1%2026-Q2
Rafferty Asset Management, LLC added38,702$1M0.1%2026-Q2
DEUTSCHE BANK AG\ added36,935$1M0.1%2026-Q2
Verdad Advisers, LP new36,003$1M0.1%2026-Q2
WELLS FARGO & COMPANY/MN added33,561$1M0.0%2026-Q2
Sofinnova Investments, Inc. trimmed32,267$1M0.0%2026-Q2
Engineers Gate Manager LP new31,958$1M0.0%2026-Q2
AQR CAPITAL MANAGEMENT LLC added29,853$954K0.0%2026-Q2
Tema ETFs LLC new29,519$943K0.0%2026-Q2
Tidal Investments LLC new29,519$943K0.0%2026-Q2
PDT Partners, LLC trimmed25,684$820K0.0%2026-Q2
Invesco Ltd. trimmed24,893$795K0.0%2026-Q2
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM added24,544$784K0.0%2026-Q2
STRS OHIO added22,100$706K0.0%2026-Q2
Creative Planning trimmed21,803$696K0.0%2026-Q2
MetLife Investment Management, LLC added21,723$694K0.0%2026-Q2
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. added21,364$683K0.0%2026-Q2
LMR Partners LLP new21,151$676K0.0%2026-Q2
Auour Investments LLC21,020$671K0.0%2026-Q2
VOYA INVESTMENT MANAGEMENT LLC trimmed20,282$648K0.0%2026-Q2
BARCLAYS PLC trimmed20,275$648K0.0%2026-Q2
D. E. Shaw & Co., Inc. trimmed20,189$645K0.0%2026-Q2
Vanguard Global Advisers, LLC added20,154$644K0.0%2026-Q2
Elmind Capital, LP trimmed20,000$639K0.0%2026-Q2

Ownership over time

Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.

HoldersTotal shares

Reading this table

Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.

About 13F filings

A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.

Learn how to read institutional ownership