Who owns Spyre Therapeutics, Inc. (SYRE)
Which tracked institutional funds hold SYRE, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See SYRE company fundamentals →
Ownership as of the 2026-Q1 13F filings (latest filed 2026-05-18). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
The tracked-fund tape on SYRE is one-sided between 2025-Q4 and 2026-Q1: 106 added or opened and 18 trimmed or exited — on balance accumulating.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
SYRE’s largest tracked holder by dollar value, FMR LLC, sizes it at 0.0% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 0.0pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in SYRE divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2025-Q4 and 2026-Q1, across 198 tracked filers holding SYRE, 125 increased or opened the position and 63 reduced or closed it; over the same quarter, open-market insider Form 4 buying and selling roughly offset.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in SYRE between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 22
- VANGUARD CAPITAL MANAGEMENT LLC$154M
- Caligan Partners LP$44M
- VANGUARD PORTFOLIO MANAGEMENT LLC$30M
- VANGUARD FIDUCIARY TRUST CO$23M
- SAMLYN CAPITAL, LLC$20M
- BOOTHBAY FUND MANAGEMENT, LLC$10M
Full exits 6
- VANGUARD GROUP INC$115M
- DEERFIELD MANAGEMENT COMPANY, L.P.$23M
- Point72 Asset Management, L.P.$22M
- Parkman Healthcare Partners LLC$4M
- Optimize Financial Inc$830K
- VIRGINIA RETIREMENT SYSTEMS ET Al$817K
Largest adds
- FMR LLC$209M
- PERCEPTIVE ADVISORS LLC$90M
- RTW INVESTMENTS, LP$74M
- Fairmount Funds Management LLC$71M
- Venrock Adviser, LLC$65M
- STATE STREET CORP$57M
Largest trims
- BlackRock, Inc.$32M
- Capital International Investors$26M
- BRAIDWELL LP$6M
- Pictet Asset Management Holding SA$5M
- Patient Square Capital LP$5M
- BARCLAYS PLC$4M
Institutional holders
One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| FMR LLC added | 11,704,787 | $590M | 14.0% | 2026-Q1 |
| RTW INVESTMENTS, LP | 4,171,996 | $210M | 5.0% | 2026-Q1 |
| Fairmount Funds Management LLC | 4,018,101 | $203M | 4.8% | 2026-Q1 |
| PERCEPTIVE ADVISORS LLC added | 3,783,225 | $191M | 4.5% | 2026-Q1 |
| Venrock Adviser, LLC | 3,685,448 | $186M | 4.4% | 2026-Q1 |
| VANGUARD CAPITAL MANAGEMENT LLC new | 3,057,401 | $154M | 3.7% | 2026-Q1 |
| BlackRock, Inc. trimmed | 2,957,794 | $149M | 3.5% | 2026-Q1 |
| Driehaus Capital Management LLC trimmed | 2,790,785 | $141M | 3.3% | 2026-Q1 |
| STATE STREET CORP added | 2,607,031 | $131M | 3.1% | 2026-Q1 |
| Paradigm Biocapital Advisors LP added | 1,957,266 | $99M | 2.3% | 2026-Q1 |
| Commodore Capital LP trimmed | 1,912,380 | $96M | 2.3% | 2026-Q1 |
| Remedium Capital Partners, LLC added | 1,907,327 | $96M | 2.3% | 2026-Q1 |
| TCG Crossover Management, LLC | 1,900,582 | $96M | 2.3% | 2026-Q1 |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | $95M | 2.3% | 2026-Q1 |
| WELLINGTON MANAGEMENT GROUP LLP added | 1,796,854 | $91M | 2.1% | 2026-Q1 |
| Capital International Investors trimmed | 1,746,129 | $88M | 2.1% | 2026-Q1 |
| GEODE CAPITAL MANAGEMENT, LLC added | 1,720,912 | $87M | 2.1% | 2026-Q1 |
| JANUS HENDERSON GROUP PLC trimmed | 1,656,164 | $84M | 2.0% | 2026-Q1 |
| RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | $82M | 1.9% | 2026-Q1 |
| PRICE T ROWE ASSOCIATES INC /MD/ trimmed | 1,598,730 | $81M | 1.9% | 2026-Q1 |
| Affinity Asset Advisors, LLC trimmed | 1,279,134 | $65M | 1.5% | 2026-Q1 |
| BANK OF AMERICA CORP /DE/ added | 1,228,093 | $62M | 1.5% | 2026-Q1 |
| BAKER BROS. ADVISORS LP | 1,000,000 | $50M | 1.2% | 2026-Q1 |
| BRAIDWELL LP trimmed | 932,823 | $47M | 1.1% | 2026-Q1 |
| FRANKLIN RESOURCES INC trimmed | 882,833 | $45M | 1.1% | 2026-Q1 |
| JPMORGAN CHASE & CO added | 979,299 | $44M | 1.1% | 2026-Q1 |
| Caligan Partners LP new | 878,127 | $44M | 1.1% | 2026-Q1 |
| Siren, L.L.C. | 818,598 | $41M | 1.0% | 2026-Q1 |
| Polar Capital Holdings Plc added | 792,847 | $40M | 0.9% | 2026-Q1 |
| UBS Group AG trimmed | 671,235 | $34M | 0.8% | 2026-Q1 |
| Capital World Investors added | 666,564 | $34M | 0.8% | 2026-Q1 |
| EMERALD ADVISERS, LLC trimmed | 613,365 | $31M | 0.7% | 2026-Q1 |
| Candriam S.C.A. added | 610,282 | $31M | 0.7% | 2026-Q1 |
| VANGUARD PORTFOLIO MANAGEMENT LLC new | 585,130 | $30M | 0.7% | 2026-Q1 |
| NORTHERN TRUST CORP added | 578,907 | $29M | 0.7% | 2026-Q1 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC trimmed | 562,653 | $28M | 0.7% | 2026-Q1 |
| Pictet Asset Management Holding SA trimmed | 491,649 | $25M | 0.6% | 2026-Q1 |
| VANGUARD FIDUCIARY TRUST CO new | 464,651 | $23M | 0.6% | 2026-Q1 |
| EMERALD MUTUAL FUND ADVISERS TRUST trimmed | 408,113 | $21M | 0.5% | 2026-Q1 |
| SAMLYN CAPITAL, LLC new | 396,661 | $20M | 0.5% | 2026-Q1 |
| ADAR1 Capital Management, LLC added | 338,323 | $17M | 0.4% | 2026-Q1 |
| Blackstone Inc. trimmed | 292,847 | $15M | 0.4% | 2026-Q1 |
| VICTORY CAPITAL MANAGEMENT INC added | 292,126 | $15M | 0.3% | 2026-Q1 |
| GOLDMAN SACHS GROUP INC trimmed | 269,938 | $14M | 0.3% | 2026-Q1 |
| Woodline Partners LP | 265,892 | $13M | 0.3% | 2026-Q1 |
| MORGAN STANLEY added | 246,719 | $12M | 0.3% | 2026-Q1 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC added | 207,314 | $10M | 0.2% | 2026-Q1 |
| BOOTHBAY FUND MANAGEMENT, LLC added | 193,031 | $10M | 0.2% | 2026-Q1 |
| Bank of New York Mellon Corp trimmed | 191,395 | $10M | 0.2% | 2026-Q1 |
| SILVERARC CAPITAL MANAGEMENT, LLC trimmed | 186,618 | $9M | 0.2% | 2026-Q1 |
| FIRST TRUST ADVISORS LP added | 178,389 | $9M | 0.2% | 2026-Q1 |
| Universal- Beteiligungs- und Servicegesellschaft mbH trimmed | 170,381 | $9M | 0.2% | 2026-Q1 |
| STEMPOINT CAPITAL LP added | 167,606 | $8M | 0.2% | 2026-Q1 |
| AMERIPRISE FINANCIAL INC added | 159,217 | $8M | 0.2% | 2026-Q1 |
| Nuveen, LLC added | 153,899 | $8M | 0.2% | 2026-Q1 |
| Ensign Peak Advisors, Inc added | 148,537 | $7M | 0.2% | 2026-Q1 |
| MILLENNIUM MANAGEMENT LLC added | 146,639 | $7M | 0.2% | 2026-Q1 |
| HighVista Strategies LLC trimmed | 146,264 | $7M | 0.2% | 2026-Q1 |
| MARSHALL WACE, LLP trimmed | 138,459 | $7M | 0.2% | 2026-Q1 |
| TD Asset Management Inc trimmed | 137,390 | $7M | 0.2% | 2026-Q1 |
| Invesco Ltd. trimmed | 132,390 | $7M | 0.2% | 2026-Q1 |
| DEUTSCHE BANK AG\ added | 129,242 | $7M | 0.2% | 2026-Q1 |
| ARMISTICE CAPITAL, LLC trimmed | 120,931 | $6M | 0.1% | 2026-Q1 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE trimmed | 112,841 | $6M | 0.1% | 2026-Q1 |
| CITADEL ADVISORS LLC added | 108,135 | $5M | 0.1% | 2026-Q1 |
| B Group, Inc. | 100,000 | $5M | 0.1% | 2026-Q1 |
| SEVEN GRAND MANAGERS, LLC | 100,000 | $5M | 0.1% | 2026-Q1 |
| F/m Investments LLC trimmed | 99,460 | $5M | 0.1% | 2026-Q1 |
| Swiss National Bank | 96,500 | $5M | 0.1% | 2026-Q1 |
| ExodusPoint Capital Management, LP added | 87,065 | $4M | 0.1% | 2026-Q1 |
| RHUMBLINE ADVISERS added | 85,121 | $4M | 0.1% | 2026-Q1 |
| MERCER GLOBAL ADVISORS INC /ADV trimmed | 71,091 | $4M | 0.1% | 2026-Q1 |
| Atle Fund Management AB new | 62,735 | $3M | 0.1% | 2026-Q1 |
| Rockefeller Capital Management L.P. added | 64,002 | $3M | 0.1% | 2026-Q1 |
| ALPS ADVISORS INC added | 63,939 | $3M | 0.1% | 2026-Q1 |
| PRUDENTIAL FINANCIAL INC new | 59,555 | $3M | 0.1% | 2026-Q1 |
| FRED ALGER MANAGEMENT, LLC added | 59,453 | $3M | 0.1% | 2026-Q1 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM added | 59,242 | $3M | 0.1% | 2026-Q1 |
| SCHRODER INVESTMENT MANAGEMENT GROUP added | 63,684 | $3M | 0.1% | 2026-Q1 |
| Rafferty Asset Management, LLC added | 56,920 | $3M | 0.1% | 2026-Q1 |
| BALYASNY ASSET MANAGEMENT L.P. trimmed | 55,477 | $3M | 0.1% | 2026-Q1 |
| VOYA INVESTMENT MANAGEMENT LLC added | 53,970 | $3M | 0.1% | 2026-Q1 |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $3M | 0.1% | 2026-Q1 |
| DIMENSIONAL FUND ADVISORS LP trimmed | 47,697 | $2M | 0.1% | 2026-Q1 |
| ALLIANCEBERNSTEIN L.P. added | 70,900 | $2M | 0.1% | 2026-Q1 |
| BARCLAYS PLC trimmed | 45,786 | $2M | 0.1% | 2026-Q1 |
| Legal & General Group Plc trimmed | 44,792 | $2M | 0.1% | 2026-Q1 |
| MetLife Investment Management, LLC added | 38,407 | $2M | 0.0% | 2026-Q1 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. added | 36,323 | $2M | 0.0% | 2026-Q1 |
| VANGUARD ASSET MANAGEMENT, Ltd new | 33,232 | $2M | 0.0% | 2026-Q1 |
| VANGUARD GROUP INC added | 3,500,641 | $115M | 2.7% | 2025-Q4 stale |
| DEERFIELD MANAGEMENT COMPANY, L.P. added | 710,626 | $23M | 0.6% | 2025-Q4 stale |
| Jefferies Financial Group Inc. | 1,388,854 | $23M | 0.6% | 2025-Q3 stale |
| Point72 Asset Management, L.P. new | 662,351 | $22M | 0.5% | 2025-Q4 stale |
| ADAGE CAPITAL PARTNERS GP, L.L.C. trimmed | 610,200 | $9M | 0.2% | 2025-Q2 stale |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC trimmed | 264,317 | $4M | 0.1% | 2025-Q3 stale |
| Parkman Healthcare Partners LLC trimmed | 124,485 | $4M | 0.1% | 2025-Q4 stale |
| Deep Track Capital, LP | 219,015 | $3M | 0.1% | 2025-Q2 stale |
| Capitolis Liquid Global Markets LLC new | 183,000 | $3M | 0.1% | 2025-Q2 stale |
| SOROS FUND MANAGEMENT LLC trimmed | 125,000 | $2M | 0.0% | 2025-Q1 stale |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.