Who owns Spyre Therapeutics (SYRE)
Which tracked institutional funds hold SYRE, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See SYRE company fundamentals →
Ownership as of the 2026-Q2 13F filings (latest filed 2026-09-22). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
The tracked-fund tape on SYRE is one-sided between 2026-Q1 and 2026-Q2: 164 added or opened and 19 trimmed or exited — on balance accumulating.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
SYRE’s largest tracked holder by dollar value, FMR LLC, sizes it at 0.1% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 0.0pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in SYRE divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2026-Q1 and 2026-Q2, across 257 tracked filers holding SYRE, 186 increased or opened the position and 85 reduced or closed it; over the same quarter, open-market insider Form 4s were net sales.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in SYRE between the 2026-Q1 and 2026-Q2 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 48
- Jupiter Topco LLC$196M
- ADAGE CAPITAL PARTNERS GP, L.L.C.$153M
- Holocene Advisors, LP$90M
- Integral Health Asset Management, LLC$29M
- JENNISON ASSOCIATES LLC$27M
- Bellevue Group AG$20M
Full exits 10
- Fairmount Funds Management LLC$203M
- JANUS HENDERSON GROUP PLC$84M
- RA CAPITAL MANAGEMENT, L.P.$82M
- BAKER BROS. ADVISORS LP$50M
- Caligan Partners LP$44M
- ExodusPoint Capital Management, LP$4M
Largest adds
- FMR LLC$566M
- BlackRock, Inc.$428M
- Paradigm Biocapital Advisors LP$242M
- PERCEPTIVE ADVISORS LLC$193M
- PRICE T ROWE ASSOCIATES INC /MD/$182M
- VANGUARD PORTFOLIO MANAGEMENT LLC$177M
Largest trims
- Commodore Capital LP$21M
- BOOTHBAY FUND MANAGEMENT, LLC$9M
- FIRST TRUST ADVISORS LP$8M
- Blackstone Inc.$4M
- SILVERARC CAPITAL MANAGEMENT, LLC$4M
- Capital International Investors$3M
Institutional holders
One row per tracked fund, most shares held first (every row is from one quarter; reported value breaks ties). “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding.
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| FMR LLC added | 13,026,187 | $1.2B | 13.9% | 2026-Q2 |
| BlackRock, Inc. added | 6,506,605 | $578M | 6.9% | 2026-Q2 |
| PERCEPTIVE ADVISORS LLC added | 4,319,496 | $383M | 4.6% | 2026-Q2 |
| RTW INVESTMENTS, LP added | 4,251,996 | $377M | 4.5% | 2026-Q2 |
| Paradigm Biocapital Advisors LP added | 3,840,778 | $341M | 4.1% | 2026-Q2 |
| VANGUARD CAPITAL MANAGEMENT LLC added | 3,448,681 | $306M | 3.7% | 2026-Q2 |
| STATE STREET CORP added | 3,057,416 | $271M | 3.3% | 2026-Q2 |
| Venrock Adviser, LLC trimmed | 2,985,448 | $265M | 3.2% | 2026-Q2 |
| PRICE T ROWE ASSOCIATES INC /MD/ added | 2,960,855 | $263M | 3.1% | 2026-Q2 |
| Driehaus Capital Management LLC added | 2,799,166 | $249M | 3.0% | 2026-Q2 |
| GEODE CAPITAL MANAGEMENT, LLC added | 2,562,265 | $239M | 2.9% | 2026-Q2 |
| VANGUARD PORTFOLIO MANAGEMENT LLC added | 2,330,098 | $207M | 2.5% | 2026-Q2 |
| Capital World Investors added | 2,315,553 | $206M | 2.5% | 2026-Q2 |
| Jupiter Topco LLC new | 2,206,936 | $196M | 2.3% | 2026-Q2 |
| TCG Crossover Management, LLC | 1,900,582 | $169M | 2.0% | 2026-Q2 |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | $168M | 2.0% | 2026-Q2 |
| BANK OF AMERICA CORP /DE/ added | 1,777,854 | $158M | 1.9% | 2026-Q2 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. added | 1,722,300 | $153M | 1.8% | 2026-Q2 |
| WELLINGTON MANAGEMENT GROUP LLP trimmed | 1,581,505 | $140M | 1.7% | 2026-Q2 |
| GOLDMAN SACHS GROUP INC added | 1,478,059 | $131M | 1.6% | 2026-Q2 |
| FRANKLIN RESOURCES INC added | 1,472,943 | $131M | 1.6% | 2026-Q2 |
| Remedium Capital Partners, LLC trimmed | 1,464,169 | $130M | 1.6% | 2026-Q2 |
| Affinity Asset Advisors, LLC | 1,279,134 | $114M | 1.4% | 2026-Q2 |
| JPMORGAN CHASE & CO added | 1,093,026 | $99M | 1.2% | 2026-Q2 |
| Holocene Advisors, LP new | 1,015,170 | $90M | 1.1% | 2026-Q2 |
| MARSHALL WACE, LLP added | 991,693 | $88M | 1.1% | 2026-Q2 |
| Polar Capital Holdings Plc added | 988,009 | $88M | 1.1% | 2026-Q2 |
| Siren, L.L.C. added | 968,598 | $86M | 1.0% | 2026-Q2 |
| Capital International Investors trimmed | 955,196 | $85M | 1.0% | 2026-Q2 |
| BRAIDWELL LP trimmed | 879,467 | $78M | 0.9% | 2026-Q2 |
| Commodore Capital LP trimmed | 846,786 | $75M | 0.9% | 2026-Q2 |
| UBS Group AG added | 843,071 | $75M | 0.9% | 2026-Q2 |
| NORTHERN TRUST CORP added | 674,529 | $60M | 0.7% | 2026-Q2 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC added | 652,958 | $58M | 0.7% | 2026-Q2 |
| Pictet Asset Management Holding SA added | 628,138 | $56M | 0.7% | 2026-Q2 |
| EMERALD ADVISERS, LLC trimmed | 567,430 | $50M | 0.6% | 2026-Q2 |
| VICTORY CAPITAL MANAGEMENT INC added | 553,980 | $49M | 0.6% | 2026-Q2 |
| VANGUARD FIDUCIARY TRUST CO added | 551,389 | $49M | 0.6% | 2026-Q2 |
| Candriam S.C.A. trimmed | 546,312 | $48M | 0.6% | 2026-Q2 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC added | 522,071 | $46M | 0.6% | 2026-Q2 |
| MORGAN STANLEY added | 499,963 | $44M | 0.5% | 2026-Q2 |
| VOYA INVESTMENT MANAGEMENT LLC added | 431,694 | $38M | 0.5% | 2026-Q2 |
| EMERALD MUTUAL FUND ADVISERS TRUST trimmed | 401,271 | $36M | 0.4% | 2026-Q2 |
| SAMLYN CAPITAL, LLC added | 400,075 | $36M | 0.4% | 2026-Q2 |
| AMERIPRISE FINANCIAL INC added | 356,082 | $32M | 0.4% | 2026-Q2 |
| Integral Health Asset Management, LLC new | 325,000 | $29M | 0.3% | 2026-Q2 |
| Woodline Partners LP added | 306,049 | $27M | 0.3% | 2026-Q2 |
| JENNISON ASSOCIATES LLC new | 303,180 | $27M | 0.3% | 2026-Q2 |
| ADAR1 Capital Management, LLC trimmed | 283,982 | $25M | 0.3% | 2026-Q2 |
| BNP PARIBAS FINANCIAL MARKETS added | 259,923 | $23M | 0.3% | 2026-Q2 |
| Bank of New York Mellon Corp added | 245,193 | $22M | 0.3% | 2026-Q2 |
| Bellevue Group AG new | 229,931 | $20M | 0.2% | 2026-Q2 |
| Cormorant Asset Management, LP new | 225,000 | $20M | 0.2% | 2026-Q2 |
| SEVEN GRAND MANAGERS, LLC added | 225,000 | $20M | 0.2% | 2026-Q2 |
| EVENTIDE ASSET MANAGEMENT, LLC new | 201,616 | $18M | 0.2% | 2026-Q2 |
| MILLENNIUM MANAGEMENT LLC added | 196,712 | $17M | 0.2% | 2026-Q2 |
| ORBIMED ADVISORS LLC new | 186,145 | $17M | 0.2% | 2026-Q2 |
| FRONTIER CAPITAL MANAGEMENT CO LLC new | 182,931 | $16M | 0.2% | 2026-Q2 |
| Nuveen, LLC added | 181,105 | $16M | 0.2% | 2026-Q2 |
| NEUBERGER BERMAN GROUP LLC new | 180,884 | $16M | 0.2% | 2026-Q2 |
| DEUTSCHE BANK AG\ added | 174,459 | $15M | 0.2% | 2026-Q2 |
| Universal- Beteiligungs- und Servicegesellschaft mbH added | 172,923 | $15M | 0.2% | 2026-Q2 |
| BALYASNY ASSET MANAGEMENT L.P. added | 147,042 | $13M | 0.2% | 2026-Q2 |
| Soleus Capital Management, L.P. new | 147,000 | $13M | 0.2% | 2026-Q2 |
| Squarepoint Ops LLC added | 139,605 | $12M | 0.1% | 2026-Q2 |
| ARMISTICE CAPITAL, LLC added | 137,588 | $12M | 0.1% | 2026-Q2 |
| Russell Investments Group, Ltd. added | 134,757 | $12M | 0.1% | 2026-Q2 |
| Ensign Peak Advisors, Inc trimmed | 126,620 | $11M | 0.1% | 2026-Q2 |
| Invesco Ltd. trimmed | 120,541 | $11M | 0.1% | 2026-Q2 |
| Blackstone Inc. trimmed | 120,177 | $11M | 0.1% | 2026-Q2 |
| Rhenman & Partners Asset Management AB new | 119,300 | $11M | 0.1% | 2026-Q2 |
| TD Asset Management Inc trimmed | 115,990 | $10M | 0.1% | 2026-Q2 |
| Swiss National Bank added | 112,500 | $10M | 0.1% | 2026-Q2 |
| STEMPOINT CAPITAL LP trimmed | 106,926 | $9M | 0.1% | 2026-Q2 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE trimmed | 104,516 | $9M | 0.1% | 2026-Q2 |
| CITADEL ADVISORS LLC trimmed | 103,100 | $9M | 0.1% | 2026-Q2 |
| Boxer Capital Management, LLC trimmed | 100,000 | $9M | 0.1% | 2026-Q2 |
| RHUMBLINE ADVISERS added | 94,763 | $8M | 0.1% | 2026-Q2 |
| BARCLAYS PLC added | 94,069 | $8M | 0.1% | 2026-Q2 |
| F/m Investments LLC trimmed | 92,618 | $8M | 0.1% | 2026-Q2 |
| ALLIANCEBERNSTEIN L.P. added | 92,540 | $5M | 0.1% | 2026-Q2 |
| PRUDENTIAL FINANCIAL INC added | 87,370 | $8M | 0.1% | 2026-Q2 |
| FEDERATED HERMES, INC. new | 85,950 | $8M | 0.1% | 2026-Q2 |
| Granahan Investment Management, LLC new | 82,991 | $7M | 0.1% | 2026-Q2 |
| CITIGROUP INC added | 82,593 | $7M | 0.1% | 2026-Q2 |
| WELLS FARGO & COMPANY/MN added | 82,506 | $7M | 0.1% | 2026-Q2 |
| HighVista Strategies LLC trimmed | 77,807 | $7M | 0.1% | 2026-Q2 |
| MERCER GLOBAL ADVISORS INC /ADV added | 71,145 | $6M | 0.1% | 2026-Q2 |
| B Group, Inc. trimmed | 70,000 | $6M | 0.1% | 2026-Q2 |
| Trexquant Investment LP new | 67,007 | $6M | 0.1% | 2026-Q2 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM added | 64,687 | $6M | 0.1% | 2026-Q2 |
| Informed Momentum Co LLC new | 60,393 | $5M | 0.1% | 2026-Q2 |
| SILVERARC CAPITAL MANAGEMENT, LLC trimmed | 59,959 | $5M | 0.1% | 2026-Q2 |
| PRINCIPAL FINANCIAL GROUP INC added | 59,747 | $5M | 0.1% | 2026-Q2 |
| Hudson Bay Capital Management LP new | 58,387 | $5M | 0.1% | 2026-Q2 |
| Atle Fund Management AB trimmed | 57,030 | $5M | 0.1% | 2026-Q2 |
| RAYMOND JAMES FINANCIAL INC added | 53,627 | $5M | 0.1% | 2026-Q2 |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $5M | 0.1% | 2026-Q2 |
| ROYCE & ASSOCIATES LP new | 51,789 | $5M | 0.1% | 2026-Q2 |
| XTX Topco Ltd added | 50,483 | $4M | 0.1% | 2026-Q2 |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.