Who owns RPTX
Which tracked institutional funds hold RPTX, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See RPTX company fundamentals →
Ownership as of the 2025-Q4 13F filings (latest filed 2026-02-23). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
11 tracked funds added or opened RPTX while 4 trimmed or exited it between 2025-Q3 and 2025-Q4 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
RPTX’s largest tracked holder by dollar value, BVF INC/IL, sizes it at 0.9% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 0.9pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in RPTX divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2025-Q3 and 2025-Q4, across 46 tracked filers holding RPTX, 21 increased or opened the position and 20 reduced or closed it; over the same quarter, there were no open-market insider Form 4s.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in RPTX between the 2025-Q3 and 2025-Q4 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 3
- MARSHALL WACE, LLP$3M
- JANE STREET GROUP, LLC$724K
- Yakira Capital Management, Inc.$693K
Full exits 3
- Versant Venture Management, LLC$5M
- MPM ASSET MANAGEMENT LLC$2M
- MPM BIOIMPACT LLC$1M
Largest adds
- BVF INC/IL$9M
- Blue Owl Capital Holdings LP$3M
- ORBIMED ADVISORS LLC$3M
- Rangeley Capital, LLC$2M
- Redmile Group, LLC$1M
- RENAISSANCE TECHNOLOGIES LLC$1M
Largest trims
- CITADEL ADVISORS LLC$610K
Institutional holders
One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| BVF INC/IL | 10,333,600 | $27M | 34.6% | 2025-Q4 |
| Blue Owl Capital Holdings LP | 3,443,659 | $9M | 11.5% | 2025-Q4 |
| ORBIMED ADVISORS LLC | 3,322,488 | $9M | 11.1% | 2025-Q4 |
| Redmile Group, LLC | 1,586,174 | $4M | 5.3% | 2025-Q4 |
| Rangeley Capital, LLC added | 1,287,829 | $3M | 4.3% | 2025-Q4 |
| MARSHALL WACE, LLP added | 1,115,744 | $3M | 3.7% | 2025-Q4 |
| RENAISSANCE TECHNOLOGIES LLC added | 981,360 | $3M | 3.3% | 2025-Q4 |
| ACADIAN ASSET MANAGEMENT LLC added | 618,672 | $2M | 2.1% | 2025-Q4 |
| TWO SIGMA INVESTMENTS, LP added | 333,694 | $868K | 1.1% | 2025-Q4 |
| JANE STREET GROUP, LLC added | 278,304 | $724K | 0.9% | 2025-Q4 |
| Yakira Capital Management, Inc. new | 266,601 | $693K | 0.9% | 2025-Q4 |
| NORTHERN TRUST CORP trimmed | 260,311 | $677K | 0.9% | 2025-Q4 |
| CITADEL ADVISORS LLC trimmed | 238,912 | $621K | 0.8% | 2025-Q4 |
| BlackRock, Inc. trimmed | 144,219 | $375K | 0.5% | 2025-Q4 |
| Militia Capital Partners, LP | 119,176 | $310K | 0.4% | 2025-Q4 |
| EQUITEC PROPRIETARY MARKETS, LLC new | 118,375 | $308K | 0.4% | 2025-Q4 |
| XTX Topco Ltd added | 116,933 | $304K | 0.4% | 2025-Q4 |
| Walleye Capital LLC added | 106,683 | $277K | 0.4% | 2025-Q4 |
| BANK OF MONTREAL /CAN/ | 104,919 | $273K | 0.4% | 2025-Q4 |
| TWO SIGMA ADVISERS, LP added | 54,200 | $141K | 0.2% | 2025-Q4 |
| Point72 Asset Management, L.P. trimmed | 51,252 | $133K | 0.2% | 2025-Q4 |
| HRT FINANCIAL LP added | 42,301 | $109K | 0.1% | 2025-Q4 |
| Quinn Opportunity Partners LLC | 40,000 | $104K | 0.1% | 2025-Q4 |
| FNY Investment Advisers, LLC added | 35,000 | $91K | 0.1% | 2025-Q4 |
| NewEdge Wealth, LLC | 32,959 | $86K | 0.1% | 2025-Q4 |
| Virtu Financial LLC added | 15,488 | $40K | 0.1% | 2025-Q4 |
| Squarepoint Ops LLC trimmed | 14,485 | $38K | 0.0% | 2025-Q4 |
| OCCUDO QUANTITATIVE STRATEGIES LP trimmed | 13,548 | $35K | 0.0% | 2025-Q4 |
| Covestor Ltd new | 13,627 | $35K | 0.0% | 2025-Q4 |
| HarbourVest Partners LLC | 12,276 | $32K | 0.0% | 2025-Q4 |
| Engineers Gate Manager LP added | 11,627 | $30K | 0.0% | 2025-Q4 |
| BANK OF AMERICA CORP /DE/ trimmed | 10,737 | $28K | 0.0% | 2025-Q4 |
| StoneX Group Inc. new | 10,603 | $28K | 0.0% | 2025-Q4 |
| CIBC WORLD MARKET INC. | 10,500 | $27K | 0.0% | 2025-Q4 |
| STIFEL FINANCIAL CORP trimmed | 10,000 | $26K | 0.0% | 2025-Q4 |
| Federation des caisses Desjardins du Quebec added | 2,259 | $6K | 0.0% | 2025-Q4 |
| SBI Securities Co., Ltd. trimmed | 1,252 | $3K | 0.0% | 2025-Q4 |
| TD Waterhouse Canada Inc. | 1,250 | $3K | 0.0% | 2025-Q4 |
| BARCLAYS PLC trimmed | 530 | $1K | 0.0% | 2025-Q4 |
| CURIO WEALTH, LLC new | 500 | $1K | 0.0% | 2025-Q4 |
| MORGAN STANLEY trimmed | 404 | $1K | 0.0% | 2025-Q4 |
| ROYAL BANK OF CANADA | 200 | $1K | 0.0% | 2025-Q4 |
| JONES FINANCIAL COMPANIES LLLP | 100 | $260 | 0.0% | 2025-Q4 |
| Steward Partners Investment Advisory, LLC | 11 | $29 | 0.0% | 2025-Q4 |
| JPMORGAN CHASE & CO | 4 | $10 | 0.0% | 2025-Q4 |
| BNP PARIBAS FINANCIAL MARKETS | 1 | $3 | 0.0% | 2025-Q4 |
| Versant Venture Management, LLC | 2,646,657 | $5M | 6.0% | 2025-Q3 stale |
| MPM ASSET MANAGEMENT LLC | 1,121,318 | $2M | 2.5% | 2025-Q3 stale |
| MPM BIOIMPACT LLC | 819,924 | $1M | 1.9% | 2025-Q3 stale |
| Aquilo Capital Management, LLC | 1,293,715 | $1M | 1.6% | 2025-Q1 stale |
| ARK Investment Management LLC trimmed | 1,124,483 | $1M | 1.4% | 2025-Q1 stale |
| MILLENNIUM MANAGEMENT LLC added | 407,858 | $567K | 0.7% | 2025-Q2 stale |
| Affinity Asset Advisors, LLC | 200,000 | $352K | 0.5% | 2025-Q3 stale |
| Nikko Asset Management Americas, Inc. | 116,249 | $162K | 0.2% | 2025-Q2 stale |
| Sumitomo Mitsui Trust Group, Inc. | 116,249 | $162K | 0.2% | 2025-Q2 stale |
| Vontobel Holding Ltd. | 40,000 | $70K | 0.1% | 2025-Q3 stale |
| IEQ CAPITAL, LLC | 38,382 | $68K | 0.1% | 2025-Q3 stale |
| VANGUARD GROUP INC trimmed | 52,857 | $52K | 0.1% | 2025-Q1 stale |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP trimmed | 40,096 | $40K | 0.1% | 2025-Q1 stale |
| Blackstone Inc. | 25,957 | $36K | 0.0% | 2025-Q2 stale |
| Lantern Wealth Advisors, LLC new | 20,000 | $35K | 0.0% | 2025-Q3 stale |
| STATE STREET CORP trimmed | 19,098 | $27K | 0.0% | 2025-Q2 stale |
| PRUDENTIAL FINANCIAL INC | 14,900 | $26K | 0.0% | 2025-Q3 stale |
| GOLDMAN SACHS GROUP INC trimmed | 17,529 | $24K | 0.0% | 2025-Q2 stale |
| GSA CAPITAL PARTNERS LLP trimmed | 13,862 | $24K | 0.0% | 2025-Q3 stale |
| Arax Advisory Partners added | 12,500 | $22K | 0.0% | 2025-Q3 stale |
| TWO SIGMA SECURITIES, LLC new | 18,987 | $19K | 0.0% | 2025-Q1 stale |
| DIMENSIONAL FUND ADVISORS LP | 13,265 | $13K | 0.0% | 2025-Q1 stale |
| SIMPLEX TRADING, LLC trimmed | 8,093 | $11K | 0.0% | 2025-Q2 stale |
| GROUP ONE TRADING LLC trimmed | 5,722 | $8K | 0.0% | 2025-Q2 stale |
| UBS Group AG trimmed | 3,553 | $6K | 0.0% | 2025-Q3 stale |
| Tower Research Capital LLC (TRC) trimmed | 3,356 | $5K | 0.0% | 2025-Q2 stale |
| FMR LLC trimmed | 1,600 | $2K | 0.0% | 2025-Q1 stale |
| RAYMOND JAMES FINANCIAL INC new | 230 | $320 | 0.0% | 2025-Q2 stale |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | — | 0.0% | 2025-Q2 stale |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.