Who owns Milestone Pharmaceuticals Inc. (MIST)
Which tracked institutional funds hold MIST, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See MIST company fundamentals →
Ownership as of the 2026-Q1 13F filings (latest filed 2026-05-18). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
The tracked-fund tape on MIST is one-sided between 2025-Q4 and 2026-Q1: 5 added or opened and 18 trimmed or exited — on balance reducing.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
MIST’s largest tracked holder by dollar value, RTW INVESTMENTS, LP, sizes it at 0.1% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 0.1pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in MIST divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2025-Q4 and 2026-Q1, across 85 tracked filers holding MIST, 42 increased or opened the position and 33 reduced or closed it; over the same quarter, open-market insider Form 4 buying and selling roughly offset.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in MIST between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 2
- GOLDMAN SACHS GROUP INC$2M
- BALYASNY ASSET MANAGEMENT L.P.$1M
Full exits 3
- ADAGE CAPITAL PARTNERS GP, L.L.C.$6M
- Stonepine Capital Management, LLC$1M
- TWO SIGMA ADVISERS, LP$1M
Largest adds
- RTW INVESTMENTS, LP$2M
- MILLENNIUM MANAGEMENT LLC$1M
- Point72 Asset Management, L.P.$318K
Largest trims
- Propel Bio Management, LLC$3M
- Pathstone Holdings, LLC$2M
- JANE STREET GROUP, LLC$2M
- Simplify Asset Management Inc.$1M
- MARSHALL WACE, LLP$1M
- MORGAN STANLEY$718K
Institutional holders
One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| RTW INVESTMENTS, LP added | 6,331,001 | $8M | 12.4% | 2026-Q1 |
| Propel Bio Management, LLC | 4,118,321 | $5M | 8.3% | 2026-Q1 |
| TWO SIGMA INVESTMENTS, LP added | 2,317,176 | $3M | 4.5% | 2026-Q1 |
| GOLDMAN SACHS GROUP INC added | 2,000,025 | $2M | 3.9% | 2026-Q1 |
| MARSHALL WACE, LLP added | 1,892,537 | $2M | 3.7% | 2026-Q1 |
| MILLENNIUM MANAGEMENT LLC added | 1,544,325 | $2M | 3.0% | 2026-Q1 |
| Simplify Asset Management Inc. | 1,506,405 | $2M | 2.9% | 2026-Q1 |
| Point72 Asset Management, L.P. added | 1,085,683 | $1M | 2.1% | 2026-Q1 |
| BALYASNY ASSET MANAGEMENT L.P. new | 851,325 | $1M | 1.7% | 2026-Q1 |
| Lion Point Capital, LP added | 820,000 | $976K | 1.6% | 2026-Q1 |
| TORONTO DOMINION BANK | 750,000 | $892K | 1.5% | 2026-Q1 |
| MORGAN STANLEY trimmed | 724,141 | $862K | 1.4% | 2026-Q1 |
| Boxer Capital Management, LLC | 666,666 | $793K | 1.3% | 2026-Q1 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP trimmed | 519,046 | $618K | 1.0% | 2026-Q1 |
| UBS Group AG added | 494,908 | $589K | 1.0% | 2026-Q1 |
| Squarepoint Ops LLC added | 336,825 | $401K | 0.7% | 2026-Q1 |
| Seven Fleet Capital Management LP new | 333,333 | $397K | 0.7% | 2026-Q1 |
| GUARDIAN WEALTH ADVISORS, LLC / NC added | 280,250 | $333K | 0.5% | 2026-Q1 |
| Aptus Capital Advisors, LLC added | 280,250 | $333K | 0.5% | 2026-Q1 |
| CITADEL ADVISORS LLC trimmed | 196,696 | $234K | 0.4% | 2026-Q1 |
| LPL Financial LLC added | 193,373 | $230K | 0.4% | 2026-Q1 |
| BNP PARIBAS FINANCIAL MARKETS trimmed | 176,504 | $210K | 0.3% | 2026-Q1 |
| BOOTHBAY FUND MANAGEMENT, LLC added | 168,675 | $201K | 0.3% | 2026-Q1 |
| JANE STREET GROUP, LLC trimmed | 159,669 | $190K | 0.3% | 2026-Q1 |
| SIMPLEX TRADING, LLC added | 149,291 | $178K | 0.3% | 2026-Q1 |
| Quadrature Capital Ltd trimmed | 149,105 | $177K | 0.3% | 2026-Q1 |
| Valeo Financial Advisors, LLC | 130,699 | $156K | 0.3% | 2026-Q1 |
| GROUP ONE TRADING LLC trimmed | 129,764 | $154K | 0.3% | 2026-Q1 |
| RENAISSANCE TECHNOLOGIES LLC added | 129,705 | $154K | 0.3% | 2026-Q1 |
| XTX Topco Ltd trimmed | 120,602 | $144K | 0.2% | 2026-Q1 |
| TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC | 100,000 | $119K | 0.2% | 2026-Q1 |
| ADAR1 Capital Management, LLC trimmed | 100,000 | $119K | 0.2% | 2026-Q1 |
| HRT FINANCIAL LP trimmed | 62,256 | $74K | 0.1% | 2026-Q1 |
| Cambridge Investment Research Advisors, Inc. added | 59,620 | $71K | 0.1% | 2026-Q1 |
| October Effect Ltd trimmed | 51,950 | $62K | 0.1% | 2026-Q1 |
| SG Americas Securities, LLC trimmed | 42,512 | $51K | 0.1% | 2026-Q1 |
| Invesco Ltd. added | 41,356 | $49K | 0.1% | 2026-Q1 |
| GEODE CAPITAL MANAGEMENT, LLC trimmed | 40,789 | $49K | 0.1% | 2026-Q1 |
| NORTHERN TRUST CORP trimmed | 38,779 | $46K | 0.1% | 2026-Q1 |
| Focus Partners Wealth | 36,000 | $43K | 0.1% | 2026-Q1 |
| Mariner, LLC added | 30,830 | $37K | 0.1% | 2026-Q1 |
| Bay Rivers Group added | 29,911 | $36K | 0.1% | 2026-Q1 |
| Federation des caisses Desjardins du Quebec | 29,781 | $35K | 0.1% | 2026-Q1 |
| GSA CAPITAL PARTNERS LLP trimmed | 26,893 | $32K | 0.1% | 2026-Q1 |
| RAYMOND JAMES FINANCIAL INC | 26,600 | $32K | 0.1% | 2026-Q1 |
| Safeguard Investment Advisory Group, LLC | 25,044 | $30K | 0.0% | 2026-Q1 |
| Welch & Forbes LLC new | 25,000 | $30K | 0.0% | 2026-Q1 |
| NATIONAL BANK OF CANADA /FI/ added | 23,500 | $28K | 0.0% | 2026-Q1 |
| STATE STREET CORP added | 22,331 | $27K | 0.0% | 2026-Q1 |
| ACADIAN ASSET MANAGEMENT LLC trimmed | 20,468 | $24K | 0.0% | 2026-Q1 |
| Stephenson & Company, Inc. | 20,000 | $24K | 0.0% | 2026-Q1 |
| JOURNEY STRATEGIC WEALTH LLC | 20,000 | $24K | 0.0% | 2026-Q1 |
| Pathstone Holdings, LLC trimmed | 17,040 | $20K | 0.0% | 2026-Q1 |
| Exit Wealth Advisors, LLC. new | 15,000 | $18K | 0.0% | 2026-Q1 |
| Vision Retirement, LLC new | 15,000 | $18K | 0.0% | 2026-Q1 |
| Taylor Financial Group, Inc. added | 15,000 | $18K | 0.0% | 2026-Q1 |
| SJS Investment Consulting Inc. | 15,000 | $18K | 0.0% | 2026-Q1 |
| AE Wealth Management LLC new | 15,000 | $18K | 0.0% | 2026-Q1 |
| EARNED WEALTH ADVISORS, LLC new | 14,756 | $18K | 0.0% | 2026-Q1 |
| Cetera Investment Advisers trimmed | 14,704 | $17K | 0.0% | 2026-Q1 |
| Beta Wealth Group, Inc. | 14,127 | $17K | 0.0% | 2026-Q1 |
| JONES FINANCIAL COMPANIES LLLP | 16,000 | $17K | 0.0% | 2026-Q1 |
| Strategic Family Wealth Counselors, L.L.C. added | 13,875 | $17K | 0.0% | 2026-Q1 |
| Creative Planning trimmed | 13,410 | $16K | 0.0% | 2026-Q1 |
| Rockefeller Capital Management L.P. added | 12,500 | $15K | 0.0% | 2026-Q1 |
| IMC-Chicago, LLC new | 10,943 | $13K | 0.0% | 2026-Q1 |
| Wealthspire Advisors, LLC added | 10,629 | $13K | 0.0% | 2026-Q1 |
| Bronte Capital Management Pty Ltd. | 10,414 | $12K | 0.0% | 2026-Q1 |
| Eaton Financial Holdings Company, LLC trimmed | 10,250 | $12K | 0.0% | 2026-Q1 |
| Bayesian Capital Management, LP trimmed | 10,015 | $12K | 0.0% | 2026-Q1 |
| Ancora Advisors LLC | 10,000 | $12K | 0.0% | 2026-Q1 |
| CWM, LLC new | 10,000 | $12K | 0.0% | 2026-Q1 |
| INTEGRAL INVESTMENT ADVISORS, INC. | 10,000 | $12K | 0.0% | 2026-Q1 |
| Secure Asset Management, LLC | 10,000 | $12K | 0.0% | 2026-Q1 |
| HighTower Advisors, LLC trimmed | 10,000 | $12K | 0.0% | 2026-Q1 |
| Tower Research Capital LLC (TRC) added | 9,147 | $11K | 0.0% | 2026-Q1 |
| ORBIMED ADVISORS LLC added | 3,221,828 | $6M | 10.6% | 2025-Q3 stale |
| ADAGE CAPITAL PARTNERS GP, L.L.C. trimmed | 2,810,037 | $6M | 9.3% | 2025-Q4 stale |
| Alta Fundamental Advisers LLC trimmed | 1,398,977 | $3M | 4.4% | 2025-Q2 stale |
| BML Capital Management, LLC | 1,136,091 | $2M | 3.6% | 2025-Q2 stale |
| SPHERA FUNDS MANAGEMENT LTD. added | 820,000 | $2M | 2.7% | 2025-Q3 stale |
| Stonepine Capital Management, LLC added | 662,666 | $1M | 2.2% | 2025-Q4 stale |
| Affinity Asset Advisors, LLC added | 666,666 | $1M | 2.2% | 2025-Q3 stale |
| TWO SIGMA ADVISERS, LP added | 619,592 | $1M | 2.1% | 2025-Q4 stale |
| Bleichroeder LP | 500,000 | $970K | 1.6% | 2025-Q2 stale |
| AMH Equity Ltd new | 231,671 | $463K | 0.8% | 2025-Q3 stale |
| NOMURA HOLDINGS INC new | 225,000 | $454K | 0.7% | 2025-Q4 stale |
| Graham Capital Management, L.P. new | 133,620 | $270K | 0.4% | 2025-Q4 stale |
| Cascades Capital Asset Management, LLC added | 77,510 | $157K | 0.3% | 2025-Q4 stale |
| Engineers Gate Manager LP added | 59,053 | $119K | 0.2% | 2025-Q4 stale |
| Qube Research & Technologies Ltd added | 34,596 | $70K | 0.1% | 2025-Q4 stale |
| CITIGROUP INC added | 33,858 | $68K | 0.1% | 2025-Q4 stale |
| Scientech Research LLC added | 30,124 | $61K | 0.1% | 2025-Q4 stale |
| Quantbot Technologies LP new | 18,990 | $38K | 0.1% | 2025-Q4 stale |
| DIMENSIONAL FUND ADVISORS LP | 39,450 | $32K | 0.1% | 2025-Q1 stale |
| Walleye Capital LLC trimmed | 15,109 | $29K | 0.0% | 2025-Q2 stale |
| MERCER GLOBAL ADVISORS INC /ADV new | 15,100 | $29K | 0.0% | 2025-Q2 stale |
| Virtu Financial LLC trimmed | 14,761 | $29K | 0.0% | 2025-Q2 stale |
| SAPIENT CAPITAL LLC new | 12,200 | $25K | 0.0% | 2025-Q3 stale |
| AQR CAPITAL MANAGEMENT LLC | 10,000 | $20K | 0.0% | 2025-Q4 stale |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.