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Institutional Ownership · SEC Form 13F

Who owns MBX Biosciences, Inc. Common Stock (MBX)


Which tracked institutional funds hold MBX, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See MBX company fundamentals →

Ownership as of the 2026-Q1 13F filings (latest filed 2026-05-18). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.

157
Institutional holders
52M
Shares held (tracked funds)

How the tape is positioned

34 tracked funds added or opened MBX while 49 trimmed or exited it between 2025-Q4 and 2026-Q1 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.

A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.

Conviction spread

MBX’s largest tracked holder by dollar value, FMR LLC, sizes it at 0.0% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 0.0pp gap the other way — the median holder sizes MBX more heavily than its largest holder by dollar value does.

Book-share is each fund’s reported value in MBX divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.

Institutional & insider positioning

Between 2025-Q4 and 2026-Q1, across 157 tracked filers holding MBX, 83 increased or opened the position and 69 reduced or closed it; over the same quarter, open-market insider Form 4s were net purchases.

This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.

New buyers & exits

Funds opening or closing a position in MBX between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.

New buyers 16

  • Polar Capital Holdings Plc$48M
  • VANGUARD CAPITAL MANAGEMENT LLC$44M
  • Caligan Partners LP$25M
  • Candriam S.C.A.$9M
  • VANGUARD PORTFOLIO MANAGEMENT LLC$9M
  • BOOTHBAY FUND MANAGEMENT, LLC$6M

Full exits 12

  • VANGUARD GROUP INC$57M
  • Point72 Asset Management, L.P.$21M
  • Trails Edge Capital Partners, LP$10M
  • Balyasny Asset Management L.P.$4M
  • JANE STREET GROUP, LLC$3M
  • Hudson Bay Capital Management LP$1M

Largest adds

  • FMR LLC$84M
  • Aaron Wealth Advisors LLC$33M
  • STEMPOINT CAPITAL LP$12M
  • BRAIDWELL LP$12M
  • PRICE T ROWE ASSOCIATES INC /MD/$4M
  • JPMORGAN CHASE & CO$3M

Largest trims

  • EcoR1 Capital, LLC$44M
  • Deep Track Capital, LP$20M
  • ORBIMED ADVISORS LLC$16M
  • Driehaus Capital Management LLC$14M
  • WELLINGTON MANAGEMENT GROUP LLP$13M
  • D. E. Shaw & Co., Inc.$13M

Institutional holders

One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).

FundSharesReported value% of valueQuarter
FMR LLC added5,322,885$294M13.0%2026-Q2
WELLINGTON MANAGEMENT GROUP LLP added4,977,523$275M12.1%2026-Q2
Frazier Life Sciences Management, L.P.6,652,013$199M8.8%2026-Q1
BlackRock, Inc. added3,323,672$183M8.1%2026-Q2
ORBIMED ADVISORS LLC trimmed3,637,887$109M4.8%2026-Q1
NEA Management Company, LLC3,614,486$108M4.8%2026-Q1
Deep Track Capital, LP trimmed2,757,569$82M3.6%2026-Q1
NVP ASSOCIATES, LLC2,136,335$64M2.8%2026-Q1
Polar Capital Holdings Plc new1,622,186$48M2.1%2026-Q1
STATE STREET CORP added864,466$48M2.1%2026-Q2
PRICE T ROWE ASSOCIATES INC /MD/ trimmed814,807$45M2.0%2026-Q2
BRAIDWELL LP added1,492,467$45M2.0%2026-Q1
VANGUARD CAPITAL MANAGEMENT LLC new1,477,592$44M1.9%2026-Q1
Aaron Wealth Advisors LLC added1,168,176$35M1.5%2026-Q1
Cormorant Asset Management, LP1,120,000$33M1.5%2026-Q1
Driehaus Capital Management LLC trimmed1,018,212$30M1.3%2026-Q1
Kynam Capital Management, LP934,799$28M1.2%2026-Q1
Woodline Partners LP trimmed900,063$27M1.2%2026-Q1
EVENTIDE ASSET MANAGEMENT, LLC890,000$27M1.2%2026-Q1
CITADEL ADVISORS LLC added865,094$26M1.1%2026-Q1
Caligan Partners LP new848,590$25M1.1%2026-Q1
Parkman Healthcare Partners LLC trimmed800,037$24M1.1%2026-Q1
EcoR1 Capital, LLC trimmed777,000$23M1.0%2026-Q1
MARSHALL WACE, LLP added401,885$22M1.0%2026-Q2
GEODE CAPITAL MANAGEMENT, LLC added670,385$20M0.9%2026-Q1
TCG Crossover Management, LLC650,000$19M0.9%2026-Q1
STEMPOINT CAPITAL LP added499,469$15M0.7%2026-Q1
Schonfeld Strategic Advisors LLC added248,670$14M0.6%2026-Q2
GOLDMAN SACHS GROUP INC added457,945$14M0.6%2026-Q1
MILLENNIUM MANAGEMENT LLC trimmed226,151$12M0.6%2026-Q2
UBS Group AG added346,914$10M0.5%2026-Q1
D. E. Shaw & Co., Inc. trimmed182,767$10M0.4%2026-Q2
Candriam S.C.A. new294,374$9M0.4%2026-Q1
VANGUARD PORTFOLIO MANAGEMENT LLC new293,295$9M0.4%2026-Q1
Rock Springs Capital Management LP added287,967$9M0.4%2026-Q1
Opaleye Management Inc.260,000$8M0.3%2026-Q1
CHARLES SCHWAB INVESTMENT MANAGEMENT INC trimmed214,908$6M0.3%2026-Q1
Elmind Capital, LP211,000$6M0.3%2026-Q1
NORTHERN TRUST CORP added210,575$6M0.3%2026-Q1
TWO SIGMA INVESTMENTS, LP trimmed113,475$6M0.3%2026-Q2
BOOTHBAY FUND MANAGEMENT, LLC added208,049$6M0.3%2026-Q1
Soleus Capital Management, L.P. trimmed178,897$5M0.2%2026-Q1
DAFNA Capital Management LLC added175,465$5M0.2%2026-Q1
VANGUARD FIDUCIARY TRUST CO new170,154$5M0.2%2026-Q1
Goelzer Investment Management, Inc. trimmed164,172$5M0.2%2026-Q1
Affinity Asset Advisors, LLC trimmed150,000$4M0.2%2026-Q1
Tetragon Partners GP Ltd added145,480$4M0.2%2026-Q1
JPMORGAN CHASE & CO added147,057$4M0.2%2026-Q1
KVP Capital Advisors, LP121,524$4M0.2%2026-Q1
TD Asset Management Inc added115,998$3M0.2%2026-Q1
Burkehill Global Management, LP100,000$3M0.1%2026-Q1
Squarepoint Ops LLC added97,215$3M0.1%2026-Q1
Invesco Ltd. added50,678$3M0.1%2026-Q2
MANUFACTURERS LIFE INSURANCE COMPANY, THE added90,634$3M0.1%2026-Q1
Nuveen, LLC added81,792$2M0.1%2026-Q1
Bank of New York Mellon Corp added80,222$2M0.1%2026-Q1
PFM Health Sciences, LP trimmed71,894$2M0.1%2026-Q1
VICTORY CAPITAL MANAGEMENT INC new71,028$2M0.1%2026-Q1
XTX Topco Ltd added53,210$2M0.1%2026-Q1
SCHRODER INVESTMENT MANAGEMENT GROUP trimmed57,322$2M0.1%2026-Q1
DIMENSIONAL FUND ADVISORS LP new46,753$1M0.1%2026-Q1
Swiss National Bank new44,400$1M0.1%2026-Q1
PLATINUM INVESTMENT MANAGEMENT LTD43,597$1M0.1%2026-Q1
AQR CAPITAL MANAGEMENT LLC trimmed22,591$1M0.1%2026-Q2
ALPS ADVISORS INC trimmed36,550$1M0.0%2026-Q1
ALGERT GLOBAL LLC new36,020$1M0.0%2026-Q1
Creative Planning added35,970$1M0.0%2026-Q1
EXCHANGE TRADED CONCEPTS, LLC new34,264$1M0.0%2026-Q1
RHUMBLINE ADVISERS added33,871$1M0.0%2026-Q1
ALLIANCEBERNSTEIN L.P. added30,500$962K0.0%2026-Q1
MORGAN STANLEY trimmed31,562$942K0.0%2026-Q1
BANK OF AMERICA CORP /DE/ trimmed28,750$858K0.0%2026-Q1
ExodusPoint Capital Management, LP trimmed28,087$838K0.0%2026-Q1
DEUTSCHE BANK AG\ added22,950$685K0.0%2026-Q1
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM added22,765$680K0.0%2026-Q1
Swiss Life Asset Management Ltd new12,130$657K0.0%2026-Q1
Cerity Partners LLC trimmed21,163$632K0.0%2026-Q1
VANGUARD GROUP INC added1,817,811$57M2.5%2025-Q4 stale
FRANKLIN RESOURCES INC added1,307,288$23M1.0%2025-Q3 stale
Point72 Asset Management, L.P. added680,609$21M0.9%2025-Q4 stale
MPM BIOIMPACT LLC added1,294,416$15M0.7%2025-Q2 stale
Trails Edge Capital Partners, LP new315,158$10M0.4%2025-Q4 stale
BAKER BROS. ADVISORS LP new277,777$5M0.2%2025-Q3 stale
RA CAPITAL MANAGEMENT, L.P. trimmed377,841$4M0.2%2025-Q2 stale
Longaeva Partners L.P. new224,433$4M0.2%2025-Q3 stale
Balyasny Asset Management L.P. added119,726$4M0.2%2025-Q4 stale
SECTORAL ASSET MANAGEMENT INC added194,898$3M0.2%2025-Q3 stale
Sio Capital Management, LLC new241,000$3M0.1%2025-Q2 stale
JANE STREET GROUP, LLC added86,581$3M0.1%2025-Q4 stale
Hudson Bay Capital Management LP85,000$1M0.1%2025-Q4 stale
Murchinson Ltd. new80,000$1M0.1%2025-Q3 stale
RENAISSANCE TECHNOLOGIES LLC new32,644$1M0.0%2025-Q4 stale
Exome Asset Management LLC trimmed52,402$917K0.0%2025-Q3 stale
Ikarian Capital, LLC new48,071$841K0.0%2025-Q3 stale
Trexquant Investment LP new24,268$765K0.0%2025-Q4 stale
FOX RUN MANAGEMENT, L.L.C. new23,820$751K0.0%2025-Q4 stale
READYSTATE ASSET MANAGEMENT LP new38,500$674K0.0%2025-Q3 stale
Ghisallo Capital Management LLC added38,250$669K0.0%2025-Q3 stale
NORGES BANK25,000$650K0.0%2025-Q3 stale
GSA CAPITAL PARTNERS LLP added19,295$609K0.0%2025-Q4 stale

Ownership over time

Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.

HoldersTotal shares

Reading this table

Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.

About 13F filings

A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.

Learn how to read institutional ownership