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Institutional Ownership · SEC Form 13F

Who owns LYEL (LYEL)


Which tracked institutional funds hold LYEL, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See LYEL company fundamentals →

Ownership as of the 2026-Q1 13F filings. 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.

74
Institutional holders
12,666,595
Shares held (tracked funds)
59.6%
Of shares outstanding

How the tape is positioned

13 tracked funds added or opened LYEL while 26 trimmed or exited it between 2025-Q4 and 2026-Q1 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.

A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.

Conviction spread

LYEL’s largest tracked holder by dollar value, ARCH Venture Management, LLC, sizes it at 9.6% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 9.6pp conviction gap — its largest holder concentrates the name more heavily than the typical one.

Book-share is each fund’s reported value in LYEL divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.

Institutional & insider positioning

Between 2025-Q4 and 2026-Q1, across 74 tracked filers holding LYEL, 42 increased or opened the position and 20 reduced or closed it; over the same quarter, open-market insider Form 4s were net purchases.

This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.

New buyers & exits

Funds opening or closing a position in LYEL between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.

New buyers 6

  • VANGUARD CAPITAL MANAGEMENT LLC$14M
  • Velan Capital Investment Management LP$2M
  • VANGUARD FIDUCIARY TRUST CO$2M
  • Opaleye Management Inc.$2M
  • DIMENSIONAL FUND ADVISORS LP$959K
  • Clearstead Advisors, LLC$801K

Full exits 5

  • MWG Caph Ltd$31M
  • VANGUARD GROUP INC$25M
  • Invesco Ltd.$3M
  • JOHNSON & JOHNSON$1M
  • Clarius Group, LLC$614K

Largest adds

  • MILLENNIUM MANAGEMENT LLC$7M
  • SUSQUEHANNA INTERNATIONAL GROUP, LLP$2M
  • RENAISSANCE TECHNOLOGIES LLC$1M
  • JANE STREET GROUP, LLC$900K
  • Qube Research & Technologies Ltd$827K
  • MARSHALL WACE, LLP$723K

Largest trims

  • ARCH Venture Management, LLC$20M
  • GSK plc$16M
  • Foresite Capital Management IV, LLC$9M
  • Orland Properties Ltd$8M
  • Decheng Capital LLC$7M
  • Almitas Capital LLC$6M

Institutional holders

One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).

FundSharesReported value% of valueQuarter
ARCH Venture Management, LLC added3,247,162$65M19.4%2026-Q1
GSK plc1,512,659$30M9.0%2026-Q1
Foresite Capital Management IV, LLC800,399$16M4.8%2026-Q1
Orland Properties Ltd754,698$15M4.5%2026-Q1
VANGUARD CAPITAL MANAGEMENT LLC new718,155$14M4.3%2026-Q1
Decheng Capital LLC692,050$14M4.1%2026-Q1
Almitas Capital LLC577,807$12M3.4%2026-Q1
Foresite Capital Management V, LLC477,078$10M2.8%2026-Q1
MILLENNIUM MANAGEMENT LLC added458,905$9M2.7%2026-Q1
CITADEL ADVISORS LLC added381,462$8M2.3%2026-Q1
venBio Partners LLC337,697$7M2.0%2026-Q1
SUSQUEHANNA INTERNATIONAL GROUP, LLP added310,198$6M1.9%2026-Q1
Alphabet Inc.293,256$6M1.8%2026-Q1
BlackRock, Inc. added191,820$4M1.1%2026-Q1
GEODE CAPITAL MANAGEMENT, LLC added166,980$3M1.0%2026-Q1
MARSHALL WACE, LLP added148,516$3M0.9%2026-Q1
RENAISSANCE TECHNOLOGIES LLC added116,411$2M0.7%2026-Q1
GOLDMAN SACHS GROUP INC added114,491$2M0.7%2026-Q1
Velan Capital Investment Management LP new102,000$2M0.6%2026-Q1
MIC Capital Management UK LLP87,028$2M0.5%2026-Q1
VANGUARD FIDUCIARY TRUST CO new86,925$2M0.5%2026-Q1
CHARLES SCHWAB INVESTMENT MANAGEMENT INC added85,971$2M0.5%2026-Q1
Opaleye Management Inc. trimmed79,097$2M0.5%2026-Q1
STATE STREET CORP added72,522$1M0.4%2026-Q1
JANE STREET GROUP, LLC added63,893$1M0.4%2026-Q1
MORGAN STANLEY added56,151$1M0.3%2026-Q1
Qube Research & Technologies Ltd added55,110$1M0.3%2026-Q1
DIMENSIONAL FUND ADVISORS LP added47,888$959K0.3%2026-Q1
RBF Capital, LLC trimmed44,094$885K0.3%2026-Q1
Ikarian Capital, LLC41,081$824K0.2%2026-Q1
Clearstead Advisors, LLC new39,916$801K0.2%2026-Q1
BANK OF AMERICA CORP /DE/ added33,321$668K0.2%2026-Q1
UBS Group AG added31,814$638K0.2%2026-Q1
NORTHERN TRUST CORP30,280$607K0.2%2026-Q1
CANADA PENSION PLAN INVESTMENT BOARD trimmed29,411$590K0.2%2026-Q1
VANGUARD PORTFOLIO MANAGEMENT LLC new23,015$462K0.1%2026-Q1
Walleye Capital LLC trimmed22,207$445K0.1%2026-Q1
Point72 Asset Management, L.P. added21,292$427K0.1%2026-Q1
Susquehanna Portfolio Strategies, LLC20,800$417K0.1%2026-Q1
Jump Financial, LLC trimmed20,123$404K0.1%2026-Q1
Squarepoint Ops LLC trimmed19,294$387K0.1%2026-Q1
BRIDGEWAY CAPITAL MANAGEMENT, LLC18,000$361K0.1%2026-Q1
AMERICAN CENTURY COMPANIES INC trimmed15,971$320K0.1%2026-Q1
Brevan Howard Capital Management LP trimmed13,435$270K0.1%2026-Q1
PRICE T ROWE ASSOCIATES INC /MD/13,128$264K0.1%2026-Q1
TWO SIGMA INVESTMENTS, LP trimmed11,585$232K0.1%2026-Q1
CITIGROUP INC added5,912$119K0.0%2026-Q1
Vanguard Global Advisers, LLC new5,165$104K0.0%2026-Q1
China Universal Asset Management Co., Ltd. added3,770$76K0.0%2026-Q1
HSG Holding Ltd152,299$73K0.0%2026-Q1
BNP PARIBAS FINANCIAL MARKETS trimmed2,097$42K0.0%2026-Q1
FMR LLC trimmed1,823$37K0.0%2026-Q1
BARCLAYS PLC trimmed1,671$34K0.0%2026-Q1
JPMORGAN CHASE & CO trimmed1,468$28K0.0%2026-Q1
Tower Research Capital LLC (TRC) added1,301$26K0.0%2026-Q1
Mirae Asset Global Investments Co., Ltd. added1,108$22K0.0%2026-Q1
JONES FINANCIAL COMPANIES LLLP1,025$20K0.0%2026-Q1
MWG Caph Ltd new1,008,116$31M9.2%2025-Q4 stale
VANGUARD GROUP INC added826,430$25M7.6%2025-Q4 stale
MWG Management Ltd.1,008,116$16M4.9%2025-Q3 stale
Invesco Ltd. added98,649$3M0.9%2025-Q4 stale
JOHNSON & JOHNSON trimmed41,165$1M0.4%2025-Q4 stale
TAKEDA PHARMACEUTICAL CO LTD added54,887$891K0.3%2025-Q3 stale
Woodline Partners LP added98,425$870K0.3%2025-Q2 stale
ORBIMED ADVISORS LLC51,727$840K0.2%2025-Q3 stale
Clarius Group, LLC19,958$614K0.2%2025-Q4 stale
TD Asset Management Inc trimmed50,232$444K0.1%2025-Q2 stale
JACOBS LEVY EQUITY MANAGEMENT, INC trimmed39,621$350K0.1%2025-Q2 stale
Nuveen, LLC new641,173$345K0.1%2025-Q1 stale
BOOTHBAY FUND MANAGEMENT, LLC trimmed9,516$293K0.1%2025-Q4 stale
Bank of New York Mellon Corp525,782$283K0.1%2025-Q1 stale
ExodusPoint Capital Management, LP trimmed8,511$262K0.1%2025-Q4 stale
RAYMOND JAMES FINANCIAL INC7,900$243K0.1%2025-Q4 stale
Candriam S.C.A. new7,617$234K0.1%2025-Q4 stale
MANUFACTURERS LIFE INSURANCE COMPANY, THE trimmed24,419$216K0.1%2025-Q2 stale
TWO SIGMA ADVISERS, LP added391,200$210K0.1%2025-Q1 stale
BBR PARTNERS, LLC trimmed6,834$210K0.1%2025-Q4 stale
Trexquant Investment LP new10,275$167K0.0%2025-Q3 stale
Rangeley Capital, LLC10,000$162K0.0%2025-Q3 stale
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. trimmed295,647$159K0.0%2025-Q1 stale
EXCHANGE TRADED CONCEPTS, LLC added246,349$133K0.0%2025-Q1 stale
RHUMBLINE ADVISERS trimmed235,694$127K0.0%2025-Q1 stale
ALLIANCEBERNSTEIN L.P.220,790$119K0.0%2025-Q1 stale
AQR CAPITAL MANAGEMENT LLC added174,279$94K0.0%2025-Q1 stale
INTECH INVESTMENT MANAGEMENT LLC added124,696$67K0.0%2025-Q1 stale
TUDOR INVESTMENT CORP ET AL124,320$67K0.0%2025-Q1 stale
ACADIAN ASSET MANAGEMENT LLC trimmed1,657$51K0.0%2025-Q4 stale
DEUTSCHE BANK AG\82,441$45K0.0%2025-Q1 stale
Corebridge Financial, Inc. trimmed78,727$42K0.0%2025-Q1 stale
D. E. Shaw & Co., Inc. trimmed77,178$42K0.0%2025-Q1 stale
SG Americas Securities, LLC trimmed71,881$39K0.0%2025-Q1 stale
Graham Capital Management, L.P. added61,609$33K0.0%2025-Q1 stale
SEI INVESTMENTS CO55,900$30K0.0%2025-Q1 stale
NEW YORK STATE COMMON RETIREMENT FUND51,263$28K0.0%2025-Q1 stale
VOYA INVESTMENT MANAGEMENT LLC trimmed50,329$27K0.0%2025-Q1 stale
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM49,523$27K0.0%2025-Q1 stale
PRUDENTIAL FINANCIAL INC48,057$26K0.0%2025-Q1 stale
ProShare Advisors LLC trimmed47,966$26K0.0%2025-Q1 stale
CIBC WORLD MARKETS CORP added35,658$19K0.0%2025-Q1 stale
Police & Firemen's Retirement System of New Jersey35,001$19K0.0%2025-Q1 stale

Ownership over time

Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.

HoldersTotal shares

Reading this table

Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.

About 13F filings

A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.

Learn how to read institutional ownership