Who owns Lexicon Pharmaceuticals, Inc. (LXRX)
Which tracked institutional funds hold LXRX, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See LXRX company fundamentals →
Ownership as of the 2026-Q1 13F filings. 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
The tracked-fund tape on LXRX is one-sided between 2025-Q4 and 2026-Q1: 32 added or opened and 4 trimmed or exited — on balance accumulating.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
LXRX’s largest tracked holder by dollar value, Artal Group S.A., sizes it at 23.9% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 23.9pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in LXRX divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2025-Q4 and 2026-Q1, across 136 tracked filers holding LXRX, 70 increased or opened the position and 48 reduced or closed it; over the same quarter, open-market insider Form 4s were net purchases.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in LXRX between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 7
- VANGUARD CAPITAL MANAGEMENT LLC$15M
- CIBC Bancorp USA Inc.$3M
- VANGUARD FIDUCIARY TRUST CO$2M
- MACKENZIE FINANCIAL CORP$1M
- ADAR1 Capital Management, LLC$1M
- VANGUARD PORTFOLIO MANAGEMENT LLC$853K
Full exits 2
- VANGUARD GROUP INC$11M
- CIBC Private Wealth Group LLC$2M
Largest adds
- Artal Group S.A.$85M
- FMR LLC$27M
- Sessa Capital IM, L.P.$24M
- Siren, L.L.C.$24M
- Point72 Asset Management, L.P.$12M
- MARSHALL WACE, LLP$2M
Largest trims
- CITADEL ADVISORS LLC$260K
- ExodusPoint Capital Management, LP$250K
Institutional holders
One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| Artal Group S.A. added | 154,734,327 | $241M | 46.5% | 2026-Q1 |
| FMR LLC added | 45,054,851 | $70M | 13.5% | 2026-Q1 |
| Siren, L.L.C. added | 44,303,518 | $69M | 13.3% | 2026-Q1 |
| Sessa Capital IM, L.P. added | 17,912,961 | $28M | 5.4% | 2026-Q1 |
| VANGUARD CAPITAL MANAGEMENT LLC new | 9,519,167 | $15M | 2.9% | 2026-Q1 |
| Point72 Asset Management, L.P. added | 7,814,606 | $12M | 2.3% | 2026-Q1 |
| MILLENNIUM MANAGEMENT LLC added | 4,944,731 | $8M | 1.5% | 2026-Q1 |
| BlackRock, Inc. added | 3,322,219 | $5M | 1.0% | 2026-Q1 |
| GEODE CAPITAL MANAGEMENT, LLC added | 3,169,111 | $5M | 1.0% | 2026-Q1 |
| JANE STREET GROUP, LLC added | 2,665,938 | $4M | 0.8% | 2026-Q1 |
| UBS Group AG trimmed | 2,483,182 | $4M | 0.7% | 2026-Q1 |
| MARSHALL WACE, LLP added | 2,376,304 | $4M | 0.7% | 2026-Q1 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP added | 2,121,164 | $3M | 0.6% | 2026-Q1 |
| CIBC Bancorp USA Inc. new | 1,800,000 | $3M | 0.5% | 2026-Q1 |
| RENAISSANCE TECHNOLOGIES LLC added | 1,600,500 | $2M | 0.5% | 2026-Q1 |
| VANGUARD FIDUCIARY TRUST CO new | 1,332,284 | $2M | 0.4% | 2026-Q1 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC added | 1,311,298 | $2M | 0.4% | 2026-Q1 |
| TWO SIGMA INVESTMENTS, LP added | 1,199,632 | $2M | 0.4% | 2026-Q1 |
| CITADEL ADVISORS LLC trimmed | 1,094,901 | $2M | 0.3% | 2026-Q1 |
| GOLDMAN SACHS GROUP INC added | 1,070,517 | $2M | 0.3% | 2026-Q1 |
| STATE STREET CORP added | 964,038 | $2M | 0.3% | 2026-Q1 |
| GSA CAPITAL PARTNERS LLP trimmed | 930,089 | $1M | 0.3% | 2026-Q1 |
| Ishara Investments LP added | 902,000 | $1M | 0.3% | 2026-Q1 |
| Hennion & Walsh Asset Management, Inc. trimmed | 848,138 | $1M | 0.3% | 2026-Q1 |
| MACKENZIE FINANCIAL CORP added | 772,677 | $1M | 0.2% | 2026-Q1 |
| ADAR1 Capital Management, LLC new | 750,000 | $1M | 0.2% | 2026-Q1 |
| VANGUARD PORTFOLIO MANAGEMENT LLC new | 546,600 | $853K | 0.2% | 2026-Q1 |
| BANK OF AMERICA CORP /DE/ added | 526,103 | $821K | 0.2% | 2026-Q1 |
| Invesco Ltd. trimmed | 512,426 | $799K | 0.2% | 2026-Q1 |
| Compagnie Lombard Odier SCmA added | 510,000 | $796K | 0.2% | 2026-Q1 |
| NORTHERN TRUST CORP added | 494,666 | $772K | 0.1% | 2026-Q1 |
| ACADIAN ASSET MANAGEMENT LLC trimmed | 445,288 | $693K | 0.1% | 2026-Q1 |
| TANG CAPITAL MANAGEMENT LLC trimmed | 399,700 | $624K | 0.1% | 2026-Q1 |
| XTX Topco Ltd added | 314,614 | $491K | 0.1% | 2026-Q1 |
| MORGAN STANLEY added | 219,862 | $343K | 0.1% | 2026-Q1 |
| Catalyst Funds Management Pty Ltd added | 207,900 | $324K | 0.1% | 2026-Q1 |
| Headlands Technologies LLC added | 191,322 | $298K | 0.1% | 2026-Q1 |
| GROUP ONE TRADING LLC trimmed | 185,006 | $289K | 0.1% | 2026-Q1 |
| CITIGROUP INC added | 166,398 | $260K | 0.0% | 2026-Q1 |
| Ikarian Capital, LLC | 164,674 | $257K | 0.0% | 2026-Q1 |
| Brevan Howard Capital Management LP new | 160,499 | $250K | 0.0% | 2026-Q1 |
| SCOTIA CAPITAL INC. new | 159,831 | $249K | 0.0% | 2026-Q1 |
| Jain Global LLC added | 154,800 | $241K | 0.0% | 2026-Q1 |
| Hudson Bay Capital Management LP added | 152,616 | $238K | 0.0% | 2026-Q1 |
| JACOBS LEVY EQUITY MANAGEMENT, INC trimmed | 130,020 | $203K | 0.0% | 2026-Q1 |
| Bridgewater Advisors Inc. new | 82,209 | $201K | 0.0% | 2026-Q1 |
| HRT FINANCIAL LP added | 122,780 | $191K | 0.0% | 2026-Q1 |
| Cerity Partners LLC trimmed | 110,458 | $172K | 0.0% | 2026-Q1 |
| Quadrature Capital Ltd added | 110,379 | $172K | 0.0% | 2026-Q1 |
| Quarry LP added | 110,000 | $172K | 0.0% | 2026-Q1 |
| Man Group plc added | 108,806 | $170K | 0.0% | 2026-Q1 |
| OMERS ADMINISTRATION Corp trimmed | 106,800 | $167K | 0.0% | 2026-Q1 |
| BARCLAYS PLC trimmed | 105,487 | $165K | 0.0% | 2026-Q1 |
| AQR CAPITAL MANAGEMENT LLC trimmed | 96,234 | $150K | 0.0% | 2026-Q1 |
| Vanguard Global Advisers, LLC new | 93,641 | $146K | 0.0% | 2026-Q1 |
| Schonfeld Strategic Advisors LLC added | 75,110 | $117K | 0.0% | 2026-Q1 |
| BANK OF NOVA SCOTIA new | 73,707 | $115K | 0.0% | 2026-Q1 |
| BANK OF MONTREAL /CAN/ | 70,000 | $109K | 0.0% | 2026-Q1 |
| LPL Financial LLC trimmed | 69,783 | $109K | 0.0% | 2026-Q1 |
| Jefferies Financial Group Inc. trimmed | 68,734 | $107K | 0.0% | 2026-Q1 |
| Diametric Capital, LP added | 67,841 | $106K | 0.0% | 2026-Q1 |
| R Squared Ltd added | 67,526 | $105K | 0.0% | 2026-Q1 |
| Straight Path Wealth Management | 62,666 | $98K | 0.0% | 2026-Q1 |
| Vanguard Personalized Indexing Management, LLC trimmed | 54,965 | $86K | 0.0% | 2026-Q1 |
| Fortis Group Advisors, LLC | 50,000 | $80K | 0.0% | 2026-Q1 |
| EntryPoint Capital, LLC added | 48,498 | $76K | 0.0% | 2026-Q1 |
| BOOTHBAY FUND MANAGEMENT, LLC | 44,315 | $69K | 0.0% | 2026-Q1 |
| WEDBUSH SECURITIES INC | 40,850 | $64K | 0.0% | 2026-Q1 |
| Jump Financial, LLC added | 40,246 | $63K | 0.0% | 2026-Q1 |
| CIBC Asset Management Inc | 39,520 | $62K | 0.0% | 2026-Q1 |
| ExodusPoint Capital Management, LP trimmed | 37,430 | $58K | 0.0% | 2026-Q1 |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 35,714 | $56K | 0.0% | 2026-Q1 |
| Graham Capital Management, L.P. trimmed | 34,027 | $53K | 0.0% | 2026-Q1 |
| PRUDENTIAL FINANCIAL INC | 33,800 | $53K | 0.0% | 2026-Q1 |
| Leonteq Securities AG | 30,000 | $47K | 0.0% | 2026-Q1 |
| KWB Wealth | 40,640 | $47K | 0.0% | 2026-Q1 |
| Pathstone Holdings, LLC trimmed | 29,774 | $46K | 0.0% | 2026-Q1 |
| PINNACLE ASSOCIATES LTD | 29,015 | $45K | 0.0% | 2026-Q1 |
| Bank of New York Mellon Corp added | 27,459 | $43K | 0.0% | 2026-Q1 |
| VANGUARD GROUP INC added | 9,606,549 | $11M | 2.1% | 2025-Q4 stale |
| CIBC Private Wealth Group LLC trimmed | 1,950,000 | $2M | 0.4% | 2025-Q4 stale |
| WELLINGTON MANAGEMENT GROUP LLP trimmed | 486,674 | $460K | 0.1% | 2025-Q2 stale |
| BBR PARTNERS, LLC added | 570,000 | $263K | 0.1% | 2025-Q1 stale |
| Nantahala Capital Management, LLC trimmed | 460,850 | $212K | 0.0% | 2025-Q1 stale |
| TWO SIGMA ADVISERS, LP added | 180,977 | $208K | 0.0% | 2025-Q4 stale |
| Virtus Investment Advisers, LLC new | 436,672 | $201K | 0.0% | 2025-Q1 stale |
| Lighthouse Investment Partners, LLC new | 126,600 | $146K | 0.0% | 2025-Q4 stale |
| Monaco Asset Management SAM trimmed | 117,188 | $135K | 0.0% | 2025-Q4 stale |
| TWO SIGMA SECURITIES, LLC added | 114,632 | $132K | 0.0% | 2025-Q4 stale |
| Aster Capital Management (DIFC) Ltd new | 130,452 | $123K | 0.0% | 2025-Q2 stale |
| ALLIANCEBERNSTEIN L.P. | 246,121 | $113K | 0.0% | 2025-Q1 stale |
| China Universal Asset Management Co., Ltd. trimmed | 63,698 | $86K | 0.0% | 2025-Q3 stale |
| Cubist Systematic Strategies, LLC trimmed | 63,484 | $86K | 0.0% | 2025-Q3 stale |
| CAXTON ASSOCIATES LLP new | 71,027 | $82K | 0.0% | 2025-Q4 stale |
| Squarepoint Ops LLC added | 60,472 | $70K | 0.0% | 2025-Q4 stale |
| Optiver Holding B.V. trimmed | 52,595 | $60K | 0.0% | 2025-Q4 stale |
| COMMONWEALTH EQUITY SERVICES, LLC trimmed | 35,738 | $48K | 0.0% | 2025-Q3 stale |
| Point72 Asia (Singapore) Pte. Ltd. trimmed | 35,024 | $47K | 0.0% | 2025-Q3 stale |
| DEUTSCHE BANK AG\ trimmed | 94,394 | $43K | 0.0% | 2025-Q1 stale |
| PRICE T ROWE ASSOCIATES INC /MD/ added | 92,248 | $43K | 0.0% | 2025-Q1 stale |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.