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Institutional Ownership · SEC Form 13F

Who owns Lexicon Pharmaceuticals, Inc. (LXRX)


Which tracked institutional funds hold LXRX, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See LXRX company fundamentals →

Ownership as of the 2026-Q1 13F filings. 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.

136
Institutional holders
323M
Shares held (tracked funds)
88.4%
Of shares outstanding

How the tape is positioned

The tracked-fund tape on LXRX is one-sided between 2025-Q4 and 2026-Q1: 32 added or opened and 4 trimmed or exited — on balance accumulating.

A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.

Conviction spread

LXRX’s largest tracked holder by dollar value, Artal Group S.A., sizes it at 23.9% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 23.9pp conviction gap — its largest holder concentrates the name more heavily than the typical one.

Book-share is each fund’s reported value in LXRX divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.

Institutional & insider positioning

Between 2025-Q4 and 2026-Q1, across 136 tracked filers holding LXRX, 70 increased or opened the position and 48 reduced or closed it; over the same quarter, open-market insider Form 4s were net purchases.

This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.

New buyers & exits

Funds opening or closing a position in LXRX between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.

New buyers 7

  • VANGUARD CAPITAL MANAGEMENT LLC$15M
  • CIBC Bancorp USA Inc.$3M
  • VANGUARD FIDUCIARY TRUST CO$2M
  • MACKENZIE FINANCIAL CORP$1M
  • ADAR1 Capital Management, LLC$1M
  • VANGUARD PORTFOLIO MANAGEMENT LLC$853K

Full exits 2

  • VANGUARD GROUP INC$11M
  • CIBC Private Wealth Group LLC$2M

Largest adds

  • Artal Group S.A.$85M
  • FMR LLC$27M
  • Sessa Capital IM, L.P.$24M
  • Siren, L.L.C.$24M
  • Point72 Asset Management, L.P.$12M
  • MARSHALL WACE, LLP$2M

Largest trims

  • CITADEL ADVISORS LLC$260K
  • ExodusPoint Capital Management, LP$250K

Institutional holders

One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).

FundSharesReported value% of valueQuarter
Artal Group S.A. added154,734,327$241M46.5%2026-Q1
FMR LLC added45,054,851$70M13.5%2026-Q1
Siren, L.L.C. added44,303,518$69M13.3%2026-Q1
Sessa Capital IM, L.P. added17,912,961$28M5.4%2026-Q1
VANGUARD CAPITAL MANAGEMENT LLC new9,519,167$15M2.9%2026-Q1
Point72 Asset Management, L.P. added7,814,606$12M2.3%2026-Q1
MILLENNIUM MANAGEMENT LLC added4,944,731$8M1.5%2026-Q1
BlackRock, Inc. added3,322,219$5M1.0%2026-Q1
GEODE CAPITAL MANAGEMENT, LLC added3,169,111$5M1.0%2026-Q1
JANE STREET GROUP, LLC added2,665,938$4M0.8%2026-Q1
UBS Group AG trimmed2,483,182$4M0.7%2026-Q1
MARSHALL WACE, LLP added2,376,304$4M0.7%2026-Q1
SUSQUEHANNA INTERNATIONAL GROUP, LLP added2,121,164$3M0.6%2026-Q1
CIBC Bancorp USA Inc. new1,800,000$3M0.5%2026-Q1
RENAISSANCE TECHNOLOGIES LLC added1,600,500$2M0.5%2026-Q1
VANGUARD FIDUCIARY TRUST CO new1,332,284$2M0.4%2026-Q1
CHARLES SCHWAB INVESTMENT MANAGEMENT INC added1,311,298$2M0.4%2026-Q1
TWO SIGMA INVESTMENTS, LP added1,199,632$2M0.4%2026-Q1
CITADEL ADVISORS LLC trimmed1,094,901$2M0.3%2026-Q1
GOLDMAN SACHS GROUP INC added1,070,517$2M0.3%2026-Q1
STATE STREET CORP added964,038$2M0.3%2026-Q1
GSA CAPITAL PARTNERS LLP trimmed930,089$1M0.3%2026-Q1
Ishara Investments LP added902,000$1M0.3%2026-Q1
Hennion & Walsh Asset Management, Inc. trimmed848,138$1M0.3%2026-Q1
MACKENZIE FINANCIAL CORP added772,677$1M0.2%2026-Q1
ADAR1 Capital Management, LLC new750,000$1M0.2%2026-Q1
VANGUARD PORTFOLIO MANAGEMENT LLC new546,600$853K0.2%2026-Q1
BANK OF AMERICA CORP /DE/ added526,103$821K0.2%2026-Q1
Invesco Ltd. trimmed512,426$799K0.2%2026-Q1
Compagnie Lombard Odier SCmA added510,000$796K0.2%2026-Q1
NORTHERN TRUST CORP added494,666$772K0.1%2026-Q1
ACADIAN ASSET MANAGEMENT LLC trimmed445,288$693K0.1%2026-Q1
TANG CAPITAL MANAGEMENT LLC trimmed399,700$624K0.1%2026-Q1
XTX Topco Ltd added314,614$491K0.1%2026-Q1
MORGAN STANLEY added219,862$343K0.1%2026-Q1
Catalyst Funds Management Pty Ltd added207,900$324K0.1%2026-Q1
Headlands Technologies LLC added191,322$298K0.1%2026-Q1
GROUP ONE TRADING LLC trimmed185,006$289K0.1%2026-Q1
CITIGROUP INC added166,398$260K0.0%2026-Q1
Ikarian Capital, LLC164,674$257K0.0%2026-Q1
Brevan Howard Capital Management LP new160,499$250K0.0%2026-Q1
SCOTIA CAPITAL INC. new159,831$249K0.0%2026-Q1
Jain Global LLC added154,800$241K0.0%2026-Q1
Hudson Bay Capital Management LP added152,616$238K0.0%2026-Q1
JACOBS LEVY EQUITY MANAGEMENT, INC trimmed130,020$203K0.0%2026-Q1
Bridgewater Advisors Inc. new82,209$201K0.0%2026-Q1
HRT FINANCIAL LP added122,780$191K0.0%2026-Q1
Cerity Partners LLC trimmed110,458$172K0.0%2026-Q1
Quadrature Capital Ltd added110,379$172K0.0%2026-Q1
Quarry LP added110,000$172K0.0%2026-Q1
Man Group plc added108,806$170K0.0%2026-Q1
OMERS ADMINISTRATION Corp trimmed106,800$167K0.0%2026-Q1
BARCLAYS PLC trimmed105,487$165K0.0%2026-Q1
AQR CAPITAL MANAGEMENT LLC trimmed96,234$150K0.0%2026-Q1
Vanguard Global Advisers, LLC new93,641$146K0.0%2026-Q1
Schonfeld Strategic Advisors LLC added75,110$117K0.0%2026-Q1
BANK OF NOVA SCOTIA new73,707$115K0.0%2026-Q1
BANK OF MONTREAL /CAN/70,000$109K0.0%2026-Q1
LPL Financial LLC trimmed69,783$109K0.0%2026-Q1
Jefferies Financial Group Inc. trimmed68,734$107K0.0%2026-Q1
Diametric Capital, LP added67,841$106K0.0%2026-Q1
R Squared Ltd added67,526$105K0.0%2026-Q1
Straight Path Wealth Management62,666$98K0.0%2026-Q1
Vanguard Personalized Indexing Management, LLC trimmed54,965$86K0.0%2026-Q1
Fortis Group Advisors, LLC50,000$80K0.0%2026-Q1
EntryPoint Capital, LLC added48,498$76K0.0%2026-Q1
BOOTHBAY FUND MANAGEMENT, LLC44,315$69K0.0%2026-Q1
WEDBUSH SECURITIES INC40,850$64K0.0%2026-Q1
Jump Financial, LLC added40,246$63K0.0%2026-Q1
CIBC Asset Management Inc39,520$62K0.0%2026-Q1
ExodusPoint Capital Management, LP trimmed37,430$58K0.0%2026-Q1
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO35,714$56K0.0%2026-Q1
Graham Capital Management, L.P. trimmed34,027$53K0.0%2026-Q1
PRUDENTIAL FINANCIAL INC33,800$53K0.0%2026-Q1
Leonteq Securities AG30,000$47K0.0%2026-Q1
KWB Wealth40,640$47K0.0%2026-Q1
Pathstone Holdings, LLC trimmed29,774$46K0.0%2026-Q1
PINNACLE ASSOCIATES LTD29,015$45K0.0%2026-Q1
Bank of New York Mellon Corp added27,459$43K0.0%2026-Q1
VANGUARD GROUP INC added9,606,549$11M2.1%2025-Q4 stale
CIBC Private Wealth Group LLC trimmed1,950,000$2M0.4%2025-Q4 stale
WELLINGTON MANAGEMENT GROUP LLP trimmed486,674$460K0.1%2025-Q2 stale
BBR PARTNERS, LLC added570,000$263K0.1%2025-Q1 stale
Nantahala Capital Management, LLC trimmed460,850$212K0.0%2025-Q1 stale
TWO SIGMA ADVISERS, LP added180,977$208K0.0%2025-Q4 stale
Virtus Investment Advisers, LLC new436,672$201K0.0%2025-Q1 stale
Lighthouse Investment Partners, LLC new126,600$146K0.0%2025-Q4 stale
Monaco Asset Management SAM trimmed117,188$135K0.0%2025-Q4 stale
TWO SIGMA SECURITIES, LLC added114,632$132K0.0%2025-Q4 stale
Aster Capital Management (DIFC) Ltd new130,452$123K0.0%2025-Q2 stale
ALLIANCEBERNSTEIN L.P.246,121$113K0.0%2025-Q1 stale
China Universal Asset Management Co., Ltd. trimmed63,698$86K0.0%2025-Q3 stale
Cubist Systematic Strategies, LLC trimmed63,484$86K0.0%2025-Q3 stale
CAXTON ASSOCIATES LLP new71,027$82K0.0%2025-Q4 stale
Squarepoint Ops LLC added60,472$70K0.0%2025-Q4 stale
Optiver Holding B.V. trimmed52,595$60K0.0%2025-Q4 stale
COMMONWEALTH EQUITY SERVICES, LLC trimmed35,738$48K0.0%2025-Q3 stale
Point72 Asia (Singapore) Pte. Ltd. trimmed35,024$47K0.0%2025-Q3 stale
DEUTSCHE BANK AG\ trimmed94,394$43K0.0%2025-Q1 stale
PRICE T ROWE ASSOCIATES INC /MD/ added92,248$43K0.0%2025-Q1 stale

Ownership over time

Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.

HoldersTotal shares

Reading this table

Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.

About 13F filings

A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.

Learn how to read institutional ownership