Who owns Karyopharm Therapeutics (KPTI)
Which tracked institutional funds hold KPTI, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See KPTI company fundamentals →
Ownership as of the 2026-Q2 13F filings (latest filed 2026-09-22). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
The tracked-fund tape on KPTI is one-sided between 2026-Q1 and 2026-Q2: 45 added or opened and 12 trimmed or exited — on balance accumulating.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
KPTI’s largest tracked holder by dollar value, RA CAPITAL MANAGEMENT, L.P., sizes it at 0.2% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 0.2pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in KPTI divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2026-Q1 and 2026-Q2, across 93 tracked filers holding KPTI, 64 increased or opened the position and 32 reduced or closed it; over the same quarter, open-market insider Form 4s were net sales.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in KPTI between the 2026-Q1 and 2026-Q2 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 8
- Kalehua Capital Management LLC$7M
- NEA Management Company, LLC$6M
- Ghisallo Capital Management LLC$5M
- SILVERARC CAPITAL MANAGEMENT, LLC$3M
- VANGUARD PORTFOLIO MANAGEMENT LLC$1M
- J. Goldman & Co LP$659K
Full exits 8
- Commodore Capital LP$11M
- T. Rowe Price Investment Management, Inc.$9M
- Ikarian Capital, LLC$4M
- ACADIAN ASSET MANAGEMENT LLC$1M
- BOOTHBAY FUND MANAGEMENT, LLC$1M
- GROUP ONE TRADING LLC$1M
Largest adds
- ACORN CAPITAL ADVISORS, LLC$13M
- BlackRock, Inc.$12M
- GOLDMAN SACHS GROUP INC$9M
- RA CAPITAL MANAGEMENT, L.P.$8M
- Avidity Partners Management LP$6M
- TWO SIGMA INVESTMENTS, LP$6M
Largest trims
- Jump Financial, LLC$542K
- XTX Topco Ltd$395K
- Engineers Gate Manager LP$294K
- JANE STREET GROUP, LLC$266K
Institutional holders
One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 1,917,354 | $19M | 7.6% | 2026-Q2 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. trimmed | 1,521,322 | $15M | 6.0% | 2026-Q2 |
| ACORN CAPITAL ADVISORS, LLC added | 1,518,113 | $15M | 6.0% | 2026-Q2 |
| GOLDMAN SACHS GROUP INC added | 1,424,658 | $14M | 5.7% | 2026-Q2 |
| BlackRock, Inc. added | 1,418,799 | $14M | 5.6% | 2026-Q2 |
| VANGUARD CAPITAL MANAGEMENT LLC added | 958,979 | $9M | 3.8% | 2026-Q2 |
| Catalio Capital Management, LP added | 940,855 | $9M | 3.7% | 2026-Q2 |
| Avidity Partners Management LP added | 924,487 | $9M | 3.7% | 2026-Q2 |
| TWO SIGMA INVESTMENTS, LP added | 695,264 | $7M | 2.8% | 2026-Q2 |
| Kalehua Capital Management LLC new | 685,644 | $7M | 2.7% | 2026-Q2 |
| NEA Management Company, LLC new | 576,780 | $6M | 2.3% | 2026-Q2 |
| GEODE CAPITAL MANAGEMENT, LLC added | 531,231 | $5M | 2.1% | 2026-Q2 |
| Ghisallo Capital Management LLC new | 500,000 | $5M | 2.0% | 2026-Q2 |
| Soleus Capital Management, L.P. | 440,000 | $4M | 1.7% | 2026-Q2 |
| UBS Group AG added | 353,545 | $3M | 1.4% | 2026-Q2 |
| STATE STREET CORP added | 325,991 | $3M | 1.3% | 2026-Q2 |
| Affinity Asset Advisors, LLC trimmed | 312,500 | $3M | 1.2% | 2026-Q2 |
| Brevan Howard Capital Management LP added | 309,817 | $3M | 1.2% | 2026-Q2 |
| MILLENNIUM MANAGEMENT LLC trimmed | 305,676 | $3M | 1.2% | 2026-Q2 |
| Boxer Capital Management, LLC | 302,536 | $3M | 1.2% | 2026-Q2 |
| Davidson Kempner Capital Management LP | 300,000 | $3M | 1.2% | 2026-Q2 |
| SILVERARC CAPITAL MANAGEMENT, LLC trimmed | 297,460 | $3M | 1.2% | 2026-Q2 |
| Eversept Partners, LP | 276,174 | $3M | 1.1% | 2026-Q2 |
| JPMORGAN CHASE & CO added | 207,609 | $2M | 0.9% | 2026-Q2 |
| MORGAN STANLEY added | 202,506 | $2M | 0.8% | 2026-Q2 |
| Trexquant Investment LP trimmed | 188,368 | $2M | 0.7% | 2026-Q2 |
| BNP PARIBAS FINANCIAL MARKETS added | 188,038 | $2M | 0.7% | 2026-Q2 |
| BARCLAYS PLC added | 165,904 | $2M | 0.7% | 2026-Q2 |
| NORTHERN TRUST CORP added | 160,006 | $2M | 0.6% | 2026-Q2 |
| VANGUARD FIDUCIARY TRUST CO added | 145,401 | $1M | 0.6% | 2026-Q2 |
| VANGUARD PORTFOLIO MANAGEMENT LLC new | 134,818 | $1M | 0.5% | 2026-Q2 |
| MARSHALL WACE, LLP added | 128,451 | $1M | 0.5% | 2026-Q2 |
| RENAISSANCE TECHNOLOGIES LLC added | 108,214 | $1M | 0.4% | 2026-Q2 |
| Jump Financial, LLC trimmed | 94,000 | $918K | 0.4% | 2026-Q2 |
| Invesco Ltd. added | 90,304 | $882K | 0.4% | 2026-Q2 |
| Connor, Clark & Lunn Investment Management Ltd. trimmed | 76,397 | $746K | 0.3% | 2026-Q2 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 71,873 | $702K | 0.3% | 2026-Q2 |
| J. Goldman & Co LP new | 67,500 | $659K | 0.3% | 2026-Q2 |
| Squarepoint Ops LLC added | 63,801 | $623K | 0.3% | 2026-Q2 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC added | 61,943 | $605K | 0.2% | 2026-Q2 |
| ROYAL BANK OF CANADA added | 60,430 | $590K | 0.2% | 2026-Q2 |
| Bank of New York Mellon Corp added | 57,262 | $559K | 0.2% | 2026-Q2 |
| Susquehanna Portfolio Strategies, LLC added | 54,545 | $533K | 0.2% | 2026-Q2 |
| XTX Topco Ltd trimmed | 53,272 | $520K | 0.2% | 2026-Q2 |
| CITADEL ADVISORS LLC added | 52,069 | $509K | 0.2% | 2026-Q2 |
| BANK OF AMERICA CORP /DE/ added | 49,924 | $488K | 0.2% | 2026-Q2 |
| Birchview Capital, LP trimmed | 42,952 | $420K | 0.2% | 2026-Q2 |
| CITIGROUP INC added | 37,917 | $370K | 0.2% | 2026-Q2 |
| Nuveen, LLC new | 37,868 | $370K | 0.2% | 2026-Q2 |
| Engineers Gate Manager LP trimmed | 33,966 | $332K | 0.1% | 2026-Q2 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. new | 33,333 | $326K | 0.1% | 2026-Q2 |
| JANE STREET GROUP, LLC trimmed | 33,173 | $324K | 0.1% | 2026-Q2 |
| TORONTO DOMINION BANK new | 30,930 | $302K | 0.1% | 2026-Q2 |
| SILVERBACK ASSET MANAGEMENT LLC trimmed | 30,000 | $293K | 0.1% | 2026-Q2 |
| Baird Financial Group, Inc. | 29,791 | $291K | 0.1% | 2026-Q2 |
| PRICE T ROWE ASSOCIATES INC /MD/ added | 27,225 | $266K | 0.1% | 2026-Q2 |
| ExodusPoint Capital Management, LP new | 26,582 | $260K | 0.1% | 2026-Q2 |
| China Universal Asset Management Co., Ltd. trimmed | 25,000 | $244K | 0.1% | 2026-Q2 |
| SIMPLEX TRADING, LLC trimmed | 24,086 | $235K | 0.1% | 2026-Q2 |
| RHUMBLINE ADVISERS new | 23,467 | $229K | 0.1% | 2026-Q2 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC new | 23,265 | $227K | 0.1% | 2026-Q2 |
| Velan Capital Investment Management LP added | 20,000 | $195K | 0.1% | 2026-Q2 |
| DEUTSCHE BANK AG\ trimmed | 19,425 | $190K | 0.1% | 2026-Q2 |
| WELLS FARGO & COMPANY/MN added | 16,903 | $165K | 0.1% | 2026-Q2 |
| SEI INVESTMENTS CO new | 15,083 | $147K | 0.1% | 2026-Q2 |
| HSBC HOLDINGS PLC added | 13,750 | $137K | 0.1% | 2026-Q2 |
| Headlands Technologies LLC new | 12,113 | $118K | 0.0% | 2026-Q2 |
| MetLife Investment Management, LLC new | 12,017 | $117K | 0.0% | 2026-Q2 |
| Y-Intercept (Hong Kong) Ltd new | 10,375 | $101K | 0.0% | 2026-Q2 |
| Quadrature Capital Ltd trimmed | 10,296 | $101K | 0.0% | 2026-Q2 |
| Commodore Capital LP new | 1,950,000 | $11M | 4.4% | 2026-Q1 stale (1 quarter behind) |
| T. Rowe Price Investment Management, Inc. added | 1,542,090 | $9M | 3.5% | 2026-Q1 stale (1 quarter behind) |
| Opaleye Management Inc. new | 930,000 | $7M | 2.8% | 2025-Q4 stale (2 quarters behind) |
| VANGUARD GROUP INC added | 559,619 | $4M | 1.7% | 2025-Q4 stale (2 quarters behind) |
| Ikarian Capital, LLC added | 733,435 | $4M | 1.7% | 2026-Q1 stale (1 quarter behind) |
| BRAIDWELL LP new | 303,370 | $2M | 0.9% | 2025-Q4 stale (2 quarters behind) |
| Exome Asset Management LLC trimmed | 295,541 | $2M | 0.9% | 2025-Q4 stale (2 quarters behind) |
| AMERIPRISE FINANCIAL INC new | 276,881 | $2M | 0.8% | 2025-Q4 stale (2 quarters behind) |
| ACADIAN ASSET MANAGEMENT LLC added | 248,957 | $1M | 0.6% | 2026-Q1 stale (1 quarter behind) |
| BOOTHBAY FUND MANAGEMENT, LLC added | 213,810 | $1M | 0.5% | 2026-Q1 stale (1 quarter behind) |
| GROUP ONE TRADING LLC added | 191,527 | $1M | 0.4% | 2026-Q1 stale (1 quarter behind) |
| Palo Alto Investors LP trimmed | 187,911 | $810K | 0.3% | 2025-Q2 stale (4 quarters behind) |
| ADAR1 Capital Management, LLC added | 136,736 | $762K | 0.3% | 2026-Q1 stale (1 quarter behind) |
| Walleye Capital LLC added | 95,672 | $704K | 0.3% | 2025-Q4 stale (2 quarters behind) |
| TWO SIGMA ADVISERS, LP added | 89,729 | $660K | 0.3% | 2025-Q4 stale (2 quarters behind) |
| C WorldWide Group Holding A/S | 100,000 | $557K | 0.2% | 2026-Q1 stale (1 quarter behind) |
| Context Capital Management, LLC new | 62,995 | $464K | 0.2% | 2025-Q4 stale (2 quarters behind) |
| BALYASNY ASSET MANAGEMENT L.P. new | 70,748 | $394K | 0.2% | 2026-Q1 stale (1 quarter behind) |
| HRT FINANCIAL LP new | 70,000 | $389K | 0.2% | 2026-Q1 stale (1 quarter behind) |
| Tetragon Partners GP Ltd new | 52,984 | $295K | 0.1% | 2026-Q1 stale (1 quarter behind) |
| DAFNA Capital Management LLC trimmed | 45,800 | $255K | 0.1% | 2026-Q1 stale (1 quarter behind) |
| PRELUDE CAPITAL MANAGEMENT, LLC new | 28,723 | $211K | 0.1% | 2025-Q4 stale (2 quarters behind) |
| Zimmer Partners, LP new | 37,500 | $209K | 0.1% | 2026-Q1 stale (1 quarter behind) |
| Centiva Capital, LP new | 30,210 | $168K | 0.1% | 2026-Q1 stale (1 quarter behind) |
| Point72 Asset Management, L.P. new | 30,000 | $167K | 0.1% | 2026-Q1 stale (1 quarter behind) |
| Persistent Asset Partners Ltd new | 18,316 | $135K | 0.1% | 2025-Q4 stale (2 quarters behind) |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP trimmed | 24,138 | $134K | 0.1% | 2026-Q1 stale (1 quarter behind) |
| OMERS ADMINISTRATION Corp new | 19,400 | $108K | 0.0% | 2026-Q1 stale (1 quarter behind) |
| Belvedere Trading LLC new | 14,563 | $95K | 0.0% | 2025-Q3 stale (3 quarters behind) |
| TUDOR INVESTMENT CORP ET AL new | 12,922 | $95K | 0.0% | 2025-Q4 stale (2 quarters behind) |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.