Who owns HRTX (HRTX)
Which tracked institutional funds hold HRTX, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See HRTX company fundamentals →
Ownership as of the 2026-Q1 13F filings. 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
The tracked-fund tape on HRTX is one-sided between 2025-Q4 and 2026-Q1: 6 added or opened and 31 trimmed or exited — on balance reducing.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
HRTX’s largest tracked holder by dollar value, Rubric Capital Management LP, sizes it at 0.3% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 0.3pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in HRTX divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2025-Q4 and 2026-Q1, across 167 tracked filers holding HRTX, 82 increased or opened the position and 79 reduced or closed it; over the same quarter, there were no open-market insider Form 4s.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in HRTX between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 4
- ORBIMED ADVISORS LLC$8M
- VANGUARD CAPITAL MANAGEMENT LLC$6M
- VANGUARD PORTFOLIO MANAGEMENT LLC$1M
- VANGUARD FIDUCIARY TRUST CO$922K
Full exits 4
- ADAGE CAPITAL PARTNERS GP, L.L.C.$15M
- VANGUARD GROUP INC$13M
- JANE STREET GROUP, LLC$2M
- TWO SIGMA ADVISERS, LP$675K
Largest adds
- Richmond Brothers, Inc.$406K
- Pale Fire Capital SE$263K
Largest trims
- Rubric Capital Management LP$15M
- Clearline Capital LP$6M
- BlackRock, Inc.$5M
- Velan Capital Investment Management LP$4M
- Focus Partners Wealth$4M
- PALISADE CAPITAL MANAGEMENT, LP$3M
Institutional holders
One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| Rubric Capital Management LP | 30,046,828 | $24M | 13.0% | 2026-Q1 |
| Clearline Capital LP | 12,235,239 | $10M | 5.3% | 2026-Q1 |
| BlackRock, Inc. trimmed | 10,106,422 | $8M | 4.4% | 2026-Q1 |
| ORBIMED ADVISORS LLC added | 9,816,940 | $8M | 4.2% | 2026-Q1 |
| Velan Capital Investment Management LP | 8,753,290 | $7M | 3.8% | 2026-Q1 |
| VANGUARD CAPITAL MANAGEMENT LLC new | 7,810,329 | $6M | 3.4% | 2026-Q1 |
| MILLENNIUM MANAGEMENT LLC added | 7,630,527 | $6M | 3.3% | 2026-Q1 |
| Tejara Capital Ltd added | 6,336,755 | $5M | 2.7% | 2026-Q1 |
| TANG CAPITAL MANAGEMENT LLC | 6,250,000 | $5M | 2.7% | 2026-Q1 |
| PALISADE CAPITAL MANAGEMENT, LP trimmed | 6,140,639 | $5M | 2.7% | 2026-Q1 |
| Congress Park Capital LLC added | 4,032,737 | $3M | 1.7% | 2026-Q1 |
| GEODE CAPITAL MANAGEMENT, LLC trimmed | 4,010,087 | $3M | 1.7% | 2026-Q1 |
| STATE STREET CORP added | 3,843,672 | $3M | 1.7% | 2026-Q1 |
| JW Asset Management, LLC added | 3,751,073 | $3M | 1.6% | 2026-Q1 |
| Pale Fire Capital SE added | 2,716,328 | $2M | 1.2% | 2026-Q1 |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,576,716 | $2M | 1.1% | 2026-Q1 |
| D. E. Shaw & Co., Inc. trimmed | 2,318,818 | $2M | 1.0% | 2026-Q1 |
| UBS Group AG added | 2,285,883 | $2M | 1.0% | 2026-Q1 |
| RENAISSANCE TECHNOLOGIES LLC trimmed | 1,718,300 | $1M | 0.7% | 2026-Q1 |
| Richmond Brothers, Inc. added | 1,436,705 | $1M | 0.6% | 2026-Q1 |
| Stonepine Capital Management, LLC added | 1,402,191 | $1M | 0.6% | 2026-Q1 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC trimmed | 1,376,367 | $1M | 0.6% | 2026-Q1 |
| VANGUARD PORTFOLIO MANAGEMENT LLC new | 1,309,312 | $1M | 0.6% | 2026-Q1 |
| NORTHERN TRUST CORP added | 1,172,525 | $938K | 0.5% | 2026-Q1 |
| VANGUARD FIDUCIARY TRUST CO new | 1,152,714 | $922K | 0.5% | 2026-Q1 |
| GOLDMAN SACHS GROUP INC added | 1,056,944 | $846K | 0.5% | 2026-Q1 |
| CM Management, LLC added | 1,000,000 | $800K | 0.4% | 2026-Q1 |
| PANAGORA ASSET MANAGEMENT INC added | 962,505 | $770K | 0.4% | 2026-Q1 |
| Squarepoint Ops LLC added | 859,958 | $688K | 0.4% | 2026-Q1 |
| Monaco Asset Management SAM trimmed | 858,122 | $687K | 0.4% | 2026-Q1 |
| CITADEL ADVISORS LLC trimmed | 759,269 | $607K | 0.3% | 2026-Q1 |
| Orchard Capital Management, LLC | 680,432 | $544K | 0.3% | 2026-Q1 |
| AQR CAPITAL MANAGEMENT LLC added | 619,136 | $495K | 0.3% | 2026-Q1 |
| Nuveen, LLC added | 526,293 | $421K | 0.2% | 2026-Q1 |
| MORGAN STANLEY trimmed | 513,413 | $411K | 0.2% | 2026-Q1 |
| ACADIAN ASSET MANAGEMENT LLC added | 513,168 | $409K | 0.2% | 2026-Q1 |
| NEXPOINT ASSET MANAGEMENT, L.P. | 475,750 | $381K | 0.2% | 2026-Q1 |
| Universal- Beteiligungs- und Servicegesellschaft mbH new | 458,766 | $367K | 0.2% | 2026-Q1 |
| Palumbo Wealth Management LLC added | 412,496 | $330K | 0.2% | 2026-Q1 |
| Bank of New York Mellon Corp trimmed | 406,806 | $325K | 0.2% | 2026-Q1 |
| Invesco Ltd. added | 326,512 | $261K | 0.1% | 2026-Q1 |
| ALLIANCEBERNSTEIN L.P. | 198,550 | $258K | 0.1% | 2026-Q1 |
| TWO SIGMA INVESTMENTS, LP trimmed | 317,400 | $254K | 0.1% | 2026-Q1 |
| Caption Management, LLC trimmed | 313,681 | $251K | 0.1% | 2026-Q1 |
| Apeiron RIA LLC added | 305,668 | $245K | 0.1% | 2026-Q1 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP trimmed | 288,253 | $231K | 0.1% | 2026-Q1 |
| Excelsior Advisor Network LLC new | 285,609 | $229K | 0.1% | 2026-Q1 |
| LOS ANGELES CAPITAL MANAGEMENT LLC trimmed | 243,003 | $194K | 0.1% | 2026-Q1 |
| XTX Topco Ltd trimmed | 209,481 | $168K | 0.1% | 2026-Q1 |
| RHUMBLINE ADVISERS trimmed | 184,549 | $148K | 0.1% | 2026-Q1 |
| Quinn Opportunity Partners LLC | 175,344 | $140K | 0.1% | 2026-Q1 |
| BANK OF AMERICA CORP /DE/ added | 160,979 | $129K | 0.1% | 2026-Q1 |
| RAYMOND JAMES FINANCIAL INC added | 138,203 | $111K | 0.1% | 2026-Q1 |
| PRICE T ROWE ASSOCIATES INC /MD/ added | 111,504 | $90K | 0.0% | 2026-Q1 |
| GSA CAPITAL PARTNERS LLP trimmed | 105,064 | $84K | 0.0% | 2026-Q1 |
| Biltmore Family Office, LLC | 100,000 | $80K | 0.0% | 2026-Q1 |
| Integrated Wealth Concepts LLC added | 95,498 | $76K | 0.0% | 2026-Q1 |
| DEUTSCHE BANK AG\ | 93,081 | $74K | 0.0% | 2026-Q1 |
| BARCLAYS PLC trimmed | 91,394 | $73K | 0.0% | 2026-Q1 |
| GROUP ONE TRADING LLC trimmed | 86,809 | $69K | 0.0% | 2026-Q1 |
| SEARLE & CO. | 86,250 | $69K | 0.0% | 2026-Q1 |
| Vanguard Global Advisers, LLC new | 83,756 | $67K | 0.0% | 2026-Q1 |
| GLENMEDE TRUST CO NA trimmed | 82,050 | $66K | 0.0% | 2026-Q1 |
| LPL Financial LLC added | 78,684 | $63K | 0.0% | 2026-Q1 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. added | 73,125 | $59K | 0.0% | 2026-Q1 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. added | 11,185,325 | $15M | 7.8% | 2025-Q4 stale |
| VANGUARD GROUP INC added | 9,820,384 | $13M | 6.9% | 2025-Q4 stale |
| Point72 Asset Management, L.P. added | 4,775,877 | $11M | 5.7% | 2025-Q1 stale |
| AIGH Capital Management LLC added | 3,009,257 | $6M | 3.4% | 2025-Q2 stale |
| BAKER BROS. ADVISORS LP trimmed | 4,251,951 | $5M | 2.9% | 2025-Q3 stale |
| JANE STREET GROUP, LLC added | 1,367,891 | $2M | 1.0% | 2025-Q4 stale |
| JACOBS LEVY EQUITY MANAGEMENT, INC added | 820,504 | $2M | 0.9% | 2025-Q2 stale |
| MARSHALL WACE, LLP trimmed | 1,308,861 | $2M | 0.9% | 2025-Q3 stale |
| Jefferies Financial Group Inc. added | 666,800 | $1M | 0.7% | 2025-Q2 stale |
| TD Asset Management Inc | 394,600 | $817K | 0.4% | 2025-Q2 stale |
| Informed Momentum Co LLC added | 349,000 | $768K | 0.4% | 2025-Q1 stale |
| TWO SIGMA ADVISERS, LP added | 519,571 | $675K | 0.4% | 2025-Q4 stale |
| WELLINGTON MANAGEMENT GROUP LLP added | 525,774 | $662K | 0.4% | 2025-Q3 stale |
| Cyndeo Wealth Partners, LLC | 248,087 | $323K | 0.2% | 2025-Q4 stale |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC trimmed | 242,000 | $315K | 0.2% | 2025-Q4 stale |
| Quadrature Capital Ltd new | 227,784 | $296K | 0.2% | 2025-Q4 stale |
| Capital Planning Advisors, LLC | 144,095 | $187K | 0.1% | 2025-Q4 stale |
| FRANKLIN RESOURCES INC added | 77,552 | $171K | 0.1% | 2025-Q1 stale |
| Glenmede Investment Management, LP added | 105,326 | $133K | 0.1% | 2025-Q3 stale |
| Corebridge Financial, Inc. trimmed | 57,515 | $127K | 0.1% | 2025-Q1 stale |
| Walleye Capital LLC trimmed | 99,335 | $125K | 0.1% | 2025-Q3 stale |
| Connor, Clark & Lunn Investment Management Ltd. added | 94,009 | $122K | 0.1% | 2025-Q4 stale |
| MetLife Investment Management, LLC trimmed | 87,754 | $114K | 0.1% | 2025-Q4 stale |
| CAROLINAS WEALTH CONSULTING LLC | 41,356 | $91K | 0.0% | 2025-Q1 stale |
| Motiv8 Investments LLC | 69,245 | $87K | 0.0% | 2025-Q3 stale |
| Horan Securities, Inc. | 41,590 | $86K | 0.0% | 2025-Q2 stale |
| J. Goldman & Co LP | 67,592 | $85K | 0.0% | 2025-Q3 stale |
| ExodusPoint Capital Management, LP trimmed | 38,699 | $85K | 0.0% | 2025-Q1 stale |
| Cutter & CO Brokerage, Inc. added | 36,465 | $80K | 0.0% | 2025-Q1 stale |
| SYNOVUS FINANCIAL CORP | 31,847 | $70K | 0.0% | 2025-Q1 stale |
| Headlands Technologies LLC added | 51,287 | $67K | 0.0% | 2025-Q4 stale |
| HRT FINANCIAL LP trimmed | 29,231 | $64K | 0.0% | 2025-Q1 stale |
| Atom Investors LP added | 48,178 | $63K | 0.0% | 2025-Q4 stale |
| CIBC WORLD MARKET INC. new | 25,900 | $57K | 0.0% | 2025-Q1 stale |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 26,894 | $56K | 0.0% | 2025-Q2 stale |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.