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Institutional Ownership · SEC Form 13F

Who owns Structure Therapeutics (GPCR)


Which tracked institutional funds hold GPCR, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See GPCR company fundamentals →

Ownership as of the 2026-Q2 13F filings (latest filed 2026-09-22). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.

184
Institutional holders
67M
Shares held (tracked funds)
31.8%
Of shares outstanding

How the tape is positioned

82 tracked funds added or opened GPCR while 45 trimmed or exited it between 2026-Q1 and 2026-Q2 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.

A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.

Conviction spread

GPCR’s largest tracked holder by dollar value, FMR LLC, sizes it at 0.0% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 0.0pp gap the other way — the median holder sizes GPCR more heavily than its largest holder by dollar value does.

Book-share is each fund’s reported value in GPCR divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.

Institutional & insider positioning

Between 2026-Q1 and 2026-Q2, across 184 tracked filers holding GPCR, 100 increased or opened the position and 168 reduced or closed it; over the same quarter, open-market insider Form 4s were net sales.

This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.

New buyers & exits

Funds opening or closing a position in GPCR between the 2026-Q1 and 2026-Q2 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.

New buyers 10

  • Jupiter Topco LLC$279M
  • RTW INVESTMENTS, LP$86M
  • ExodusPoint Capital Management, LP$4M
  • ADAGE CAPITAL PARTNERS GP, L.L.C.$4M
  • Y-Intercept (Hong Kong) Ltd$1M
  • NOMURA HOLDINGS INC$1M

Full exits 22

  • Exor N.V.$5.0B
  • Paradigm Biocapital Advisors LP$26M
  • BALYASNY ASSET MANAGEMENT L.P.$15M
  • Pentwater Capital Management LP$12M
  • Sio Capital Management, LLC$10M
  • Holocene Advisors, LP$8M

Largest adds

  • Deep Track Capital, LP$48M
  • WELLINGTON MANAGEMENT GROUP LLP$47M
  • MORGAN STANLEY$40M
  • Avoro Capital Advisors LLC$36M
  • ORBIMED ADVISORS LLC$25M
  • DEERFIELD MANAGEMENT COMPANY, L.P.$21M

Largest trims

  • PRICE T ROWE ASSOCIATES INC /MD/$51M
  • Siren, L.L.C.$17M
  • ALLIANCEBERNSTEIN L.P.$15M
  • JPMORGAN CHASE & CO$9M
  • STEMPOINT CAPITAL LP$8M
  • VOLORIDGE INVESTMENT MANAGEMENT, LLC$6M

Institutional holders

One row per tracked fund, most shares held first (every row is from one quarter; reported value breaks ties). “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding.

FundSharesReported value% of valueQuarter
FMR LLC trimmed7,810,306$419M11.7%2026-Q2
WELLINGTON MANAGEMENT GROUP LLP added7,379,433$396M11.0%2026-Q2
Avoro Capital Advisors LLC6,555,555$352M9.8%2026-Q2
Jupiter Topco LLC new5,204,212$279M7.8%2026-Q2
Deep Track Capital, LP added4,740,072$254M7.1%2026-Q2
BVF INC/IL trimmed3,366,823$181M5.0%2026-Q2
MORGAN STANLEY added2,806,640$151M4.2%2026-Q2
ORBIMED ADVISORS LLC added2,209,400$119M3.3%2026-Q2
PRINCIPAL FINANCIAL GROUP INC trimmed1,752,753$94M2.6%2026-Q2
AMERICAN CENTURY COMPANIES INC added1,682,179$90M2.5%2026-Q2
RTW INVESTMENTS, LP added1,607,507$86M2.4%2026-Q2
Driehaus Capital Management LLC trimmed1,553,219$83M2.3%2026-Q2
BAKER BROS. ADVISORS LP1,432,529$77M2.1%2026-Q2
Casdin Capital, LLC1,175,000$63M1.8%2026-Q2
DEERFIELD MANAGEMENT COMPANY, L.P. added1,086,000$58M1.6%2026-Q2
CAPITOLIS LIQUID GLOBAL MARKETS LLC trimmed1,041,100$56M1.6%2026-Q2
Siren, L.L.C. trimmed872,967$47M1.3%2026-Q2
PRICE T ROWE ASSOCIATES INC /MD/ trimmed845,532$45M1.3%2026-Q2
Pacific Heights Asset Management LLC added800,000$43M1.2%2026-Q2
Rock Springs Capital Management LP added640,317$34M1.0%2026-Q2
Aberdeen Group plc added639,915$34M1.0%2026-Q2
ALLIANCEBERNSTEIN L.P. trimmed611,708$29M0.8%2026-Q2
FRANKLIN RESOURCES INC added578,839$31M0.9%2026-Q2
BANK OF AMERICA CORP /DE/ added563,422$30M0.8%2026-Q2
BlackRock, Inc. added511,149$27M0.8%2026-Q2
Logos Global Management LP500,000$27M0.7%2026-Q2
Parkman Healthcare Partners LLC added485,661$26M0.7%2026-Q2
Davern Capital Partners, LP added446,059$24M0.7%2026-Q2
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND trimmed418,800$22M0.6%2026-Q2
UBS Group AG added378,986$20M0.6%2026-Q2
DEUTSCHE BANK AG\331,867$18M0.5%2026-Q2
NEXTBio Capital Management LP added312,496$17M0.5%2026-Q2
Catalio Capital Management, LP added276,550$15M0.4%2026-Q2
MARSHALL WACE, LLP added267,592$14M0.4%2026-Q2
HSG Holding Ltd266,062$14M0.4%2026-Q2
SEB Asset Management AB245,043$13M0.4%2026-Q2
GOLDMAN SACHS GROUP INC trimmed242,790$13M0.4%2026-Q2
AMERIPRISE FINANCIAL INC added230,514$12M0.3%2026-Q2
NATIONAL BANK OF CANADA /FI/ trimmed215,800$12M0.3%2026-Q2
TWO SIGMA INVESTMENTS, LP added204,156$11M0.3%2026-Q2
Eversept Partners, LP added196,302$11M0.3%2026-Q2
Schonfeld Strategic Advisors LLC added190,685$10M0.3%2026-Q2
Woodline Partners LP trimmed153,808$8M0.2%2026-Q2
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. added153,119$8M0.2%2026-Q2
ArrowMark Colorado Holdings LLC trimmed150,579$8M0.2%2026-Q2
Susquehanna Portfolio Strategies, LLC added148,948$8M0.2%2026-Q2
CenterBook Partners LP added148,030$8M0.2%2026-Q2
Rhenman & Partners Asset Management AB added145,100$8M0.2%2026-Q2
B Group, Inc. added140,000$8M0.2%2026-Q2
HighVista Strategies LLC added130,784$7M0.2%2026-Q2
Universal- Beteiligungs- und Servicegesellschaft mbH added125,689$7M0.2%2026-Q2
Squarepoint Ops LLC added125,575$7M0.2%2026-Q2
SUSQUEHANNA INTERNATIONAL GROUP, LLP added122,344$7M0.2%2026-Q2
D. E. Shaw & Co., Inc. trimmed115,300$6M0.2%2026-Q2
VOLORIDGE INVESTMENT MANAGEMENT, LLC trimmed112,300$6M0.2%2026-Q2
Soleus Capital Management, L.P. added107,000$6M0.2%2026-Q2
Avidity Partners Management LP added98,000$5M0.1%2026-Q2
GEODE CAPITAL MANAGEMENT, LLC added97,183$5M0.1%2026-Q2
Qube Research & Technologies Ltd added93,403$5M0.1%2026-Q2
PEREGRINE CAPITAL MANAGEMENT LLC trimmed92,229$5M0.1%2026-Q2
PFM Health Sciences, LP trimmed91,550$5M0.1%2026-Q2
PLATINUM INVESTMENT MANAGEMENT LTD added90,363$5M0.1%2026-Q2
MILLENNIUM MANAGEMENT LLC trimmed89,568$5M0.1%2026-Q2
ExodusPoint Capital Management, LP new78,266$4M0.1%2026-Q2
ADAGE CAPITAL PARTNERS GP, L.L.C. trimmed75,000$4M0.1%2026-Q2
Boxer Capital Management, LLC75,000$4M0.1%2026-Q2
Cormorant Asset Management, LP trimmed75,000$4M0.1%2026-Q2
ALPS ADVISORS INC added71,833$4M0.1%2026-Q2
TD Asset Management Inc trimmed68,962$4M0.1%2026-Q2
Brevan Howard Capital Management LP added60,336$3M0.1%2026-Q2
Burkehill Global Management, LP60,000$3M0.1%2026-Q2
RAYMOND JAMES FINANCIAL INC added59,357$3M0.1%2026-Q2
TUDOR INVESTMENT CORP ET AL trimmed53,656$3M0.1%2026-Q2
ANTIPODES PARTNERS Ltd added51,262$3M0.1%2026-Q2
SEVEN GRAND MANAGERS, LLC50,000$3M0.1%2026-Q2
Buckland Partners Management Co LLC50,000$3M0.1%2026-Q2
DAFNA Capital Management LLC46,500$2M0.1%2026-Q2
Mariner, LLC added46,285$2M0.1%2026-Q2
OSAIC HOLDINGS, INC. added44,786$2M0.1%2026-Q2
STATE STREET CORP trimmed44,629$2M0.1%2026-Q2
VOYA INVESTMENT MANAGEMENT LLC44,410$2M0.1%2026-Q2
BANQUE PICTET & CIE SA trimmed43,332$2M0.1%2026-Q2
Jump Financial, LLC trimmed42,658$2M0.1%2026-Q2
BANK OF MONTREAL /CAN/ added42,570$2M0.1%2026-Q2
Cinctive Capital Management LP added40,877$2M0.1%2026-Q2
Jefferies Financial Group Inc. trimmed40,625$2M0.1%2026-Q2
Jones Hill Capital LP trimmed40,567$2M0.1%2026-Q2
STEMPOINT CAPITAL LP trimmed38,178$2M0.1%2026-Q2
MANUFACTURERS LIFE INSURANCE COMPANY, THE trimmed38,108$2M0.1%2026-Q2
CAPITAL FUND MANAGEMENT S.A. added37,281$2M0.1%2026-Q2
PSquared Asset Management AG added37,200$2M0.1%2026-Q2
FLAX POND CAPITAL, LLC added37,000$2M0.0%2026-Q2
TrueMark Investments, LLC trimmed33,600$2M0.1%2026-Q2
NOMURA ASSET MANAGEMENT CO LTD32,790$2M0.0%2026-Q2
DCF Advisers, LLC added32,100$2M0.0%2026-Q2
EXCHANGE TRADED CONCEPTS, LLC added30,773$2M0.0%2026-Q2
Private Capital Advisors, Inc. trimmed29,760$2M0.0%2026-Q2
SPHERA FUNDS MANAGEMENT LTD. trimmed28,600$2M0.0%2026-Q2
Verition Fund Management LLC added28,519$2M0.0%2026-Q2
Y-Intercept (Hong Kong) Ltd added27,573$1M0.0%2026-Q2

Ownership over time

Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.

HoldersTotal shares

Reading this table

Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.

About 13F filings

A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.

Learn how to read institutional ownership