Who owns GPCR (GPCR)
Which tracked institutional funds hold GPCR, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See GPCR company fundamentals →
Ownership as of the 2026-Q1 13F filings. 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
The tracked-fund tape on GPCR is one-sided between 2025-Q4 and 2026-Q1: 38 added or opened and 117 trimmed or exited — on balance reducing.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
GPCR’s largest tracked holder by dollar value, FMR LLC, sizes it at 0.0% of its own reported 13F book, while the median holder sizes it at 0.1% of theirs — a 0.1pp gap the other way — the median holder sizes GPCR more heavily than its largest holder by dollar value does.
Book-share is each fund’s reported value in GPCR divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2025-Q4 and 2026-Q1, across 198 tracked filers holding GPCR, 112 increased or opened the position and 101 reduced or closed it; over the same quarter, open-market insider Form 4 buying and selling roughly offset.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in GPCR between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 20
- CAPITOLIS LIQUID GLOBAL MARKETS LLC$55M
- Paradigm Biocapital Advisors LP$26M
- SEB Asset Management AB$12M
- Pentwater Capital Management LP$12M
- Cormorant Asset Management, LP$8M
- Holocene Advisors, LP$8M
Full exits 23
- Capitolis Liquid Global Markets LLC$61M
- CITADEL ADVISORS LLC$54M
- FARALLON CAPITAL MANAGEMENT LLC$32M
- EcoR1 Capital, LLC$23M
- Capricorn Fund Managers Ltd$18M
- JANE STREET GROUP, LLC$10M
Largest adds
- AMERICAN CENTURY COMPANIES INC$34M
- D. E. Shaw & Co., Inc.$9M
- BANK OF AMERICA CORP /DE/$9M
- JPMORGAN CHASE & CO$8M
- Schonfeld Strategic Advisors LLC$7M
- Parkman Healthcare Partners LLC$7M
Largest trims
- JANUS HENDERSON GROUP PLC$347M
- FMR LLC$203M
- WELLINGTON MANAGEMENT GROUP LLP$146M
- Avoro Capital Advisors LLC$140M
- Deep Track Capital, LP$80M
- BVF INC/IL$75M
Institutional holders
One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| FMR LLC trimmed | 8,350,182 | $402M | 12.2% | 2026-Q1 |
| WELLINGTON MANAGEMENT GROUP LLP added | 7,246,704 | $349M | 10.6% | 2026-Q1 |
| Avoro Capital Advisors LLC | 6,555,555 | $316M | 9.6% | 2026-Q1 |
| Deep Track Capital, LP added | 4,279,848 | $206M | 6.2% | 2026-Q1 |
| BVF INC/IL trimmed | 3,459,358 | $167M | 5.0% | 2026-Q1 |
| MORGAN STANLEY added | 2,305,457 | $111M | 3.4% | 2026-Q1 |
| PRICE T ROWE ASSOCIATES INC /MD/ added | 2,000,696 | $96M | 2.9% | 2026-Q1 |
| PRINCIPAL FINANCIAL GROUP INC added | 1,753,764 | $85M | 2.6% | 2026-Q1 |
| Driehaus Capital Management LLC trimmed | 1,577,356 | $76M | 2.3% | 2026-Q1 |
| ORBIMED ADVISORS LLC added | 1,475,403 | $71M | 2.2% | 2026-Q1 |
| AMERICAN CENTURY COMPANIES INC added | 1,438,031 | $69M | 2.1% | 2026-Q1 |
| BAKER BROS. ADVISORS LP | 1,432,529 | $69M | 2.1% | 2026-Q1 |
| Siren, L.L.C. added | 1,328,698 | $64M | 1.9% | 2026-Q1 |
| Casdin Capital, LLC | 1,175,000 | $57M | 1.7% | 2026-Q1 |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC new | 1,151,300 | $55M | 1.7% | 2026-Q1 |
| ALLIANCEBERNSTEIN L.P. trimmed | 638,813 | $44M | 1.3% | 2026-Q1 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 767,993 | $37M | 1.1% | 2026-Q1 |
| Pacific Heights Asset Management LLC added | 750,000 | $36M | 1.1% | 2026-Q1 |
| Rock Springs Capital Management LP trimmed | 640,217 | $31M | 0.9% | 2026-Q1 |
| Paradigm Biocapital Advisors LP added | 545,287 | $26M | 0.8% | 2026-Q1 |
| FRANKLIN RESOURCES INC trimmed | 531,595 | $26M | 0.8% | 2026-Q1 |
| Logos Global Management LP trimmed | 500,000 | $24M | 0.7% | 2026-Q1 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 467,800 | $23M | 0.7% | 2026-Q1 |
| BlackRock, Inc. added | 441,975 | $21M | 0.6% | 2026-Q1 |
| Aberdeen Group plc added | 391,809 | $19M | 0.6% | 2026-Q1 |
| DEUTSCHE BANK AG\ trimmed | 331,867 | $16M | 0.5% | 2026-Q1 |
| NATIONAL BANK OF CANADA /FI/ added | 305,400 | $15M | 0.4% | 2026-Q1 |
| BALYASNY ASSET MANAGEMENT L.P. added | 304,934 | $15M | 0.4% | 2026-Q1 |
| GOLDMAN SACHS GROUP INC added | 260,543 | $13M | 0.4% | 2026-Q1 |
| Catalio Capital Management, LP added | 255,379 | $12M | 0.4% | 2026-Q1 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC added | 254,969 | $12M | 0.4% | 2026-Q1 |
| SEB Asset Management AB new | 245,043 | $12M | 0.4% | 2026-Q1 |
| Pentwater Capital Management LP new | 245,000 | $12M | 0.4% | 2026-Q1 |
| Parkman Healthcare Partners LLC added | 232,093 | $11M | 0.3% | 2026-Q1 |
| BANK OF AMERICA CORP /DE/ added | 227,132 | $11M | 0.3% | 2026-Q1 |
| AMERIPRISE FINANCIAL INC trimmed | 219,516 | $11M | 0.3% | 2026-Q1 |
| UBS Group AG added | 212,919 | $10M | 0.3% | 2026-Q1 |
| Sio Capital Management, LLC added | 209,093 | $10M | 0.3% | 2026-Q1 |
| D. E. Shaw & Co., Inc. added | 204,790 | $10M | 0.3% | 2026-Q1 |
| TD Asset Management Inc added | 204,762 | $10M | 0.3% | 2026-Q1 |
| STEMPOINT CAPITAL LP trimmed | 200,267 | $10M | 0.3% | 2026-Q1 |
| JPMORGAN CHASE & CO added | 212,803 | $9M | 0.3% | 2026-Q1 |
| Woodline Partners LP added | 190,808 | $9M | 0.3% | 2026-Q1 |
| ArrowMark Colorado Holdings LLC trimmed | 188,195 | $9M | 0.3% | 2026-Q1 |
| TWO SIGMA INVESTMENTS, LP added | 181,415 | $9M | 0.3% | 2026-Q1 |
| Cormorant Asset Management, LP trimmed | 175,000 | $8M | 0.3% | 2026-Q1 |
| MILLENNIUM MANAGEMENT LLC added | 168,931 | $8M | 0.2% | 2026-Q1 |
| Schonfeld Strategic Advisors LLC added | 165,426 | $8M | 0.2% | 2026-Q1 |
| Holocene Advisors, LP trimmed | 159,009 | $8M | 0.2% | 2026-Q1 |
| JANUS HENDERSON GROUP PLC trimmed | 150,817 | $7M | 0.2% | 2026-Q1 |
| TCG Crossover Management, LLC trimmed | 140,411 | $7M | 0.2% | 2026-Q1 |
| Eversept Partners, LP added | 138,036 | $7M | 0.2% | 2026-Q1 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. added | 134,015 | $6M | 0.2% | 2026-Q1 |
| NEXTBio Capital Management LP added | 133,239 | $6M | 0.2% | 2026-Q1 |
| HSG Holding Ltd | 266,062 | $6M | 0.2% | 2026-Q1 |
| Rhenman & Partners Asset Management AB trimmed | 128,100 | $6M | 0.2% | 2026-Q1 |
| B Group, Inc. added | 127,500 | $6M | 0.2% | 2026-Q1 |
| Davern Capital Partners, LP new | 126,461 | $6M | 0.2% | 2026-Q1 |
| PFM Health Sciences, LP added | 126,383 | $6M | 0.2% | 2026-Q1 |
| HighVista Strategies LLC trimmed | 123,909 | $6M | 0.2% | 2026-Q1 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE added | 114,814 | $6M | 0.2% | 2026-Q1 |
| Universal- Beteiligungs- und Servicegesellschaft mbH added | 109,638 | $5M | 0.2% | 2026-Q1 |
| Trexquant Investment LP added | 107,884 | $5M | 0.2% | 2026-Q1 |
| Jump Financial, LLC added | 107,857 | $5M | 0.2% | 2026-Q1 |
| SCHRODER INVESTMENT MANAGEMENT GROUP trimmed | 118,225 | $5M | 0.2% | 2026-Q1 |
| Jones Hill Capital LP new | 100,593 | $5M | 0.1% | 2026-Q1 |
| Birchview Capital, LP added | 100,000 | $5M | 0.1% | 2026-Q1 |
| PEREGRINE CAPITAL MANAGEMENT LLC added | 97,117 | $5M | 0.1% | 2026-Q1 |
| Soleus Capital Management, L.P. trimmed | 80,000 | $4M | 0.1% | 2026-Q1 |
| TUDOR INVESTMENT CORP ET AL added | 75,301 | $4M | 0.1% | 2026-Q1 |
| Boxer Capital Management, LLC | 75,000 | $4M | 0.1% | 2026-Q1 |
| Qube Research & Technologies Ltd added | 73,599 | $4M | 0.1% | 2026-Q1 |
| DIADEMA PARTNERS LP new | 72,234 | $3M | 0.1% | 2026-Q1 |
| Capitolis Liquid Global Markets LLC new | 878,300 | $61M | 1.8% | 2025-Q4 stale |
| CITADEL ADVISORS LLC added | 772,518 | $54M | 1.6% | 2025-Q4 stale |
| RA CAPITAL MANAGEMENT, L.P. | 1,517,418 | $42M | 1.3% | 2025-Q3 stale |
| Capital Research Global Investors trimmed | 2,164,145 | $37M | 1.1% | 2025-Q1 stale |
| Capital International Investors trimmed | 1,618,876 | $34M | 1.0% | 2025-Q2 stale |
| FARALLON CAPITAL MANAGEMENT LLC new | 454,000 | $32M | 1.0% | 2025-Q4 stale |
| EcoR1 Capital, LLC new | 334,380 | $23M | 0.7% | 2025-Q4 stale |
| FIL Ltd trimmed | 1,150,440 | $20M | 0.6% | 2025-Q1 stale |
| Capricorn Fund Managers Ltd new | 252,600 | $18M | 0.5% | 2025-Q4 stale |
| Point72 Asset Management, L.P. added | 407,700 | $11M | 0.3% | 2025-Q3 stale |
| Nantahala Capital Management, LLC added | 368,553 | $10M | 0.3% | 2025-Q3 stale |
| JANE STREET GROUP, LLC added | 147,217 | $10M | 0.3% | 2025-Q4 stale |
| Alyeska Investment Group, L.P. trimmed | 115,000 | $8M | 0.2% | 2025-Q4 stale |
| TWO SIGMA ADVISERS, LP added | 249,299 | $7M | 0.2% | 2025-Q3 stale |
| RTW INVESTMENTS, LP trimmed | 100,000 | $7M | 0.2% | 2025-Q4 stale |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 99,617 | $7M | 0.2% | 2025-Q4 stale |
| READYSTATE ASSET MANAGEMENT LP added | 237,188 | $7M | 0.2% | 2025-Q3 stale |
| SummitTX Capital, L.P. new | 94,671 | $7M | 0.2% | 2025-Q4 stale |
| SIMPLEX TRADING, LLC added | 92,668 | $6M | 0.2% | 2025-Q4 stale |
| First Light Asset Management, LLC added | 197,350 | $6M | 0.2% | 2025-Q3 stale |
| Camber Capital Management LP | 300,000 | $5M | 0.2% | 2025-Q1 stale |
| Handelsbanken Fonder AB trimmed | 168,000 | $5M | 0.1% | 2025-Q3 stale |
| Foresite Capital Management VI LLC trimmed | 210,000 | $4M | 0.1% | 2025-Q2 stale |
| Longaeva Partners L.P. new | 60,000 | $4M | 0.1% | 2025-Q4 stale |
| Candriam S.C.A. trimmed | 214,063 | $4M | 0.1% | 2025-Q1 stale |
| SILVERARC CAPITAL MANAGEMENT, LLC trimmed | 175,636 | $4M | 0.1% | 2025-Q2 stale |
| CANADA PENSION PLAN INVESTMENT BOARD new | 167,800 | $3M | 0.1% | 2025-Q2 stale |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.