Who owns Edgewise Therapeutics (EWTX)
Which tracked institutional funds hold EWTX, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See EWTX company fundamentals →
Ownership as of the 2026-Q2 13F filings (latest filed 2026-09-22). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
The tracked-fund tape on EWTX is one-sided between 2026-Q1 and 2026-Q2: 113 added or opened and 28 trimmed or exited — on balance accumulating.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
EWTX’s largest tracked holder by dollar value, ORBIMED ADVISORS LLC, sizes it at 12.0% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 12.0pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in EWTX divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2026-Q1 and 2026-Q2, across 216 tracked filers holding EWTX, 122 increased or opened the position and 107 reduced or closed it; over the same quarter, open-market insider Form 4s were net sales.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in EWTX between the 2026-Q1 and 2026-Q2 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 15
- Jupiter Topco LLC$247M
- Tyro Capital Management LLC$25M
- ADAGE CAPITAL PARTNERS GP, L.L.C.$19M
- DIADEMA PARTNERS LP$11M
- HSBC HOLDINGS PLC$4M
- BOOTHBAY FUND MANAGEMENT, LLC$3M
Full exits 17
- JANUS HENDERSON GROUP PLC$186M
- Bellevue Group AG$48M
- Candriam S.C.A.$14M
- MILLENNIUM MANAGEMENT LLC$11M
- STEMPOINT CAPITAL LP$9M
- Sio Capital Management, LLC$8M
Largest adds
- FMR LLC$191M
- Paradigm Biocapital Advisors LP$183M
- ORBIMED ADVISORS LLC$142M
- BlackRock, Inc.$65M
- Driehaus Capital Management LLC$51M
- NOVO HOLDINGS A/S$49M
Largest trims
- BAKER BROS. ADVISORS LP$57M
- UBS Group AG$34M
- Soleus Capital Management, L.P.$27M
- MARSHALL WACE, LLP$20M
- Siren, L.L.C.$10M
- FEDERATED HERMES, INC.$2M
Institutional holders
One row per tracked fund, most shares held first (every row is from one quarter; reported value breaks ties). “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding.
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 15,518,492 | $631M | 13.2% | 2026-Q2 |
| Paradigm Biocapital Advisors LP added | 10,215,455 | $415M | 8.7% | 2026-Q2 |
| RA CAPITAL MANAGEMENT, L.P. trimmed | 8,392,730 | $341M | 7.1% | 2026-Q2 |
| BlackRock, Inc. added | 6,606,336 | $268M | 5.6% | 2026-Q2 |
| Jupiter Topco LLC new | 6,075,331 | $247M | 5.2% | 2026-Q2 |
| FMR LLC added | 5,489,135 | $223M | 4.7% | 2026-Q2 |
| NOVO HOLDINGS A/S | 5,350,000 | $217M | 4.6% | 2026-Q2 |
| Driehaus Capital Management LLC added | 4,728,623 | $192M | 4.0% | 2026-Q2 |
| PERCEPTIVE ADVISORS LLC trimmed | 4,373,974 | $178M | 3.7% | 2026-Q2 |
| VANGUARD CAPITAL MANAGEMENT LLC added | 3,860,670 | $157M | 3.3% | 2026-Q2 |
| BAKER BROS. ADVISORS LP trimmed | 3,701,719 | $150M | 3.1% | 2026-Q2 |
| Siren, L.L.C. trimmed | 3,184,629 | $129M | 2.7% | 2026-Q2 |
| Cormorant Asset Management, LP trimmed | 2,510,000 | $102M | 2.1% | 2026-Q2 |
| GEODE CAPITAL MANAGEMENT, LLC added | 2,174,051 | $88M | 1.9% | 2026-Q2 |
| ALLIANCEBERNSTEIN L.P. added | 2,119,024 | $67M | 1.4% | 2026-Q2 |
| Integral Health Asset Management, LLC added | 2,000,000 | $81M | 1.7% | 2026-Q2 |
| BRAIDWELL LP trimmed | 1,996,965 | $81M | 1.7% | 2026-Q2 |
| MORGAN STANLEY trimmed | 1,948,597 | $79M | 1.7% | 2026-Q2 |
| STATE STREET CORP added | 1,827,927 | $74M | 1.6% | 2026-Q2 |
| MPM BIOIMPACT LLC trimmed | 1,620,780 | $66M | 1.4% | 2026-Q2 |
| BANK OF AMERICA CORP /DE/ added | 1,558,260 | $63M | 1.3% | 2026-Q2 |
| Qube Research & Technologies Ltd added | 1,252,507 | $51M | 1.1% | 2026-Q2 |
| DIMENSIONAL FUND ADVISORS LP trimmed | 1,139,726 | $46M | 1.0% | 2026-Q2 |
| AMERICAN CENTURY COMPANIES INC trimmed | 1,127,078 | $46M | 1.0% | 2026-Q2 |
| First Light Asset Management, LLC added | 1,095,171 | $44M | 0.9% | 2026-Q2 |
| VICTORY CAPITAL MANAGEMENT INC added | 902,870 | $37M | 0.8% | 2026-Q2 |
| PRICE T ROWE ASSOCIATES INC /MD/ added | 816,518 | $33M | 0.7% | 2026-Q2 |
| VANGUARD PORTFOLIO MANAGEMENT LLC added | 786,456 | $32M | 0.7% | 2026-Q2 |
| NORTHERN TRUST CORP added | 671,270 | $27M | 0.6% | 2026-Q2 |
| Aberdeen Group plc trimmed | 647,926 | $26M | 0.6% | 2026-Q2 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC added | 620,532 | $25M | 0.5% | 2026-Q2 |
| Tyro Capital Management LLC new | 612,965 | $25M | 0.5% | 2026-Q2 |
| GOLDMAN SACHS GROUP INC trimmed | 599,469 | $24M | 0.5% | 2026-Q2 |
| Parkman Healthcare Partners LLC added | 577,036 | $23M | 0.5% | 2026-Q2 |
| Artisan Partners Limited Partnership trimmed | 574,925 | $23M | 0.5% | 2026-Q2 |
| VANGUARD FIDUCIARY TRUST CO added | 548,285 | $22M | 0.5% | 2026-Q2 |
| NORGES BANK added | 510,140 | $21M | 0.4% | 2026-Q2 |
| Opaleye Management Inc. | 500,000 | $20M | 0.4% | 2026-Q2 |
| CITADEL ADVISORS LLC added | 469,707 | $19M | 0.4% | 2026-Q2 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. added | 462,000 | $19M | 0.4% | 2026-Q2 |
| Soleus Capital Management, L.P. trimmed | 450,889 | $18M | 0.4% | 2026-Q2 |
| Nuveen, LLC added | 414,706 | $17M | 0.4% | 2026-Q2 |
| Sofinnova Investments, Inc. trimmed | 380,923 | $15M | 0.3% | 2026-Q2 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND trimmed | 334,014 | $14M | 0.3% | 2026-Q2 |
| RAYMOND JAMES FINANCIAL INC added | 317,565 | $13M | 0.3% | 2026-Q2 |
| Squadron Capital Management LLC trimmed | 290,000 | $12M | 0.2% | 2026-Q2 |
| Universal- Beteiligungs- und Servicegesellschaft mbH added | 283,333 | $12M | 0.2% | 2026-Q2 |
| DIADEMA PARTNERS LP added | 272,214 | $11M | 0.2% | 2026-Q2 |
| PRUDENTIAL FINANCIAL INC added | 260,725 | $11M | 0.2% | 2026-Q2 |
| KENNEDY CAPITAL MANAGEMENT LLC trimmed | 256,608 | $10M | 0.2% | 2026-Q2 |
| Schonfeld Strategic Advisors LLC added | 255,202 | $10M | 0.2% | 2026-Q2 |
| DEUTSCHE BANK AG\ added | 244,995 | $10M | 0.2% | 2026-Q2 |
| DAFNA Capital Management LLC added | 226,819 | $9M | 0.2% | 2026-Q2 |
| Woodline Partners LP | 224,290 | $9M | 0.2% | 2026-Q2 |
| Bank of New York Mellon Corp added | 212,347 | $9M | 0.2% | 2026-Q2 |
| JPMORGAN CHASE & CO added | 203,151 | $8M | 0.2% | 2026-Q2 |
| PEREGRINE CAPITAL MANAGEMENT LLC trimmed | 198,570 | $8M | 0.2% | 2026-Q2 |
| SEB Asset Management AB trimmed | 194,063 | $8M | 0.2% | 2026-Q2 |
| Granahan Investment Management, LLC trimmed | 193,778 | $8M | 0.2% | 2026-Q2 |
| NEUBERGER BERMAN GROUP LLC added | 191,195 | $8M | 0.2% | 2026-Q2 |
| BARCLAYS PLC added | 190,205 | $8M | 0.2% | 2026-Q2 |
| D. E. Shaw & Co., Inc. added | 189,115 | $8M | 0.2% | 2026-Q2 |
| UBS Group AG trimmed | 174,967 | $7M | 0.1% | 2026-Q2 |
| ADAR1 Capital Management, LLC added | 143,199 | $6M | 0.1% | 2026-Q2 |
| KVP Capital Advisors, LP | 133,000 | $5M | 0.1% | 2026-Q2 |
| Invesco Ltd. trimmed | 120,932 | $5M | 0.1% | 2026-Q2 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC added | 118,209 | $5M | 0.1% | 2026-Q2 |
| Point72 Asset Management, L.P. added | 117,262 | $5M | 0.1% | 2026-Q2 |
| Quantum Private Wealth, LLC trimmed | 113,380 | $5M | 0.1% | 2026-Q2 |
| ALPS ADVISORS INC added | 108,795 | $4M | 0.1% | 2026-Q2 |
| Moody Aldrich Partners LLC trimmed | 104,952 | $4M | 0.1% | 2026-Q2 |
| Artia Global Partners LP added | 98,800 | $4M | 0.1% | 2026-Q2 |
| Swiss National Bank trimmed | 96,800 | $4M | 0.1% | 2026-Q2 |
| VOYA INVESTMENT MANAGEMENT LLC added | 94,671 | $4M | 0.1% | 2026-Q2 |
| HSBC HOLDINGS PLC added | 91,638 | $4M | 0.1% | 2026-Q2 |
| HighVista Strategies LLC trimmed | 90,996 | $4M | 0.1% | 2026-Q2 |
| RHUMBLINE ADVISERS added | 90,232 | $4M | 0.1% | 2026-Q2 |
| Ally Bridge Group (NY) LLC trimmed | 83,300 | $3M | 0.1% | 2026-Q2 |
| BOOTHBAY FUND MANAGEMENT, LLC trimmed | 82,734 | $3M | 0.1% | 2026-Q2 |
| NEW YORK STATE COMMON RETIREMENT FUND trimmed | 80,197 | $3M | 0.1% | 2026-Q2 |
| WELLS FARGO & COMPANY/MN added | 78,898 | $3M | 0.1% | 2026-Q2 |
| Russell Investments Group, Ltd. added | 77,733 | $3M | 0.1% | 2026-Q2 |
| Jefferies Financial Group Inc. new | 71,389 | $3M | 0.1% | 2026-Q2 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM trimmed | 71,306 | $3M | 0.1% | 2026-Q2 |
| Persistent Asset Partners Ltd added | 69,441 | $3M | 0.1% | 2026-Q2 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. trimmed | 64,918 | $3M | 0.1% | 2026-Q2 |
| CITIGROUP INC added | 59,563 | $2M | 0.1% | 2026-Q2 |
| TUDOR INVESTMENT CORP ET AL added | 56,934 | $2M | 0.0% | 2026-Q2 |
| STATE OF WISCONSIN INVESTMENT BOARD added | 56,910 | $2M | 0.0% | 2026-Q2 |
| HighMark Wealth Management LLC | 53,179 | $2M | 0.0% | 2026-Q2 |
| TWO SIGMA INVESTMENTS, LP trimmed | 49,548 | $2M | 0.0% | 2026-Q2 |
| SEI INVESTMENTS CO trimmed | 47,543 | $2M | 0.0% | 2026-Q2 |
| ALGERT GLOBAL LLC added | 47,240 | $2M | 0.0% | 2026-Q2 |
| XTX Topco Ltd added | 45,832 | $2M | 0.0% | 2026-Q2 |
| Legal & General Group Plc added | 44,688 | $2M | 0.0% | 2026-Q2 |
| BNP PARIBAS FINANCIAL MARKETS added | 43,587 | $2M | 0.0% | 2026-Q2 |
| MetLife Investment Management, LLC added | 41,804 | $2M | 0.0% | 2026-Q2 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE added | 40,757 | $2M | 0.0% | 2026-Q2 |
| Ensign Peak Advisors, Inc trimmed | 40,379 | $2M | 0.0% | 2026-Q2 |
| Creative Planning added | 39,198 | $2M | 0.0% | 2026-Q2 |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.