Who owns Design Therapeutics (DSGN)
Which tracked institutional funds hold DSGN, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See DSGN company fundamentals →
Ownership as of the 2026-Q2 13F filings (latest filed 2026-09-22). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
54 tracked funds added or opened DSGN while 19 trimmed or exited it between 2026-Q1 and 2026-Q2 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
DSGN’s largest tracked holder by dollar value, SR One Capital Management, LP, sizes it at 9.1% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 9.1pp conviction gap — its largest holder concentrates the name more heavily than the typical one.
Book-share is each fund’s reported value in DSGN divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2026-Q1 and 2026-Q2, across 134 tracked filers holding DSGN, 89 increased or opened the position and 50 reduced or closed it; over the same quarter, there were no open-market insider Form 4s.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in DSGN between the 2026-Q1 and 2026-Q2 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 10
- Frazier Life Sciences Management, L.P.$26M
- Sofinnova Investments, Inc.$13M
- Siren, L.L.C.$8M
- Eversept Partners, LP$3M
- KVP Capital Advisors, LP$3M
- J. Goldman & Co LP$3M
Full exits 7
- RA CAPITAL MANAGEMENT, L.P.$32M
- Kynam Capital Management, LP$8M
- ACADIAN ASSET MANAGEMENT LLC$7M
- MARSHALL WACE, LLP$2M
- Lynx1 Capital Management LP$1M
- JANE STREET GROUP, LLC$1M
Largest adds
- SR One Capital Management, LP$25M
- Logos Global Management LP$23M
- Driehaus Capital Management LLC$20M
- Trails Edge Capital Partners, LP$20M
- BlackRock, Inc.$16M
- Caption Management, LLC$15M
Largest trims
- D. E. Shaw & Co., Inc.$2M
- Almitas Capital LLC$1M
- CITADEL ADVISORS LLC$1M
- Invesco Ltd.$1M
- SEI INVESTMENTS CO$1M
- Trexquant Investment LP$839K
Institutional holders
One row per tracked fund, most shares held first (every row is from one quarter; reported value breaks ties). “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding.
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| SR One Capital Management, LP | 6,526,476 | $94M | 15.3% | 2026-Q2 |
| Logos Global Management LP added | 3,000,000 | $43M | 7.0% | 2026-Q2 |
| BAKER BROS. ADVISORS LP added | 2,678,430 | $39M | 6.3% | 2026-Q2 |
| Driehaus Capital Management LLC added | 2,661,115 | $39M | 6.2% | 2026-Q2 |
| BlackRock, Inc. added | 2,660,024 | $38M | 6.2% | 2026-Q2 |
| Point72 Asset Management, L.P. trimmed | 2,366,453 | $34M | 5.5% | 2026-Q2 |
| Trails Edge Capital Partners, LP added | 2,001,282 | $29M | 4.7% | 2026-Q2 |
| Frazier Life Sciences Management, L.P. added | 1,809,854 | $26M | 4.2% | 2026-Q2 |
| Vivo Capital, LLC | 1,612,903 | $23M | 3.8% | 2026-Q2 |
| VANGUARD CAPITAL MANAGEMENT LLC added | 1,571,022 | $23M | 3.7% | 2026-Q2 |
| Caption Management, LLC added | 1,118,098 | $16M | 2.6% | 2026-Q2 |
| Almitas Capital LLC trimmed | 1,026,893 | $15M | 2.4% | 2026-Q2 |
| GEODE CAPITAL MANAGEMENT, LLC added | 958,417 | $14M | 2.2% | 2026-Q2 |
| Sofinnova Investments, Inc. new | 865,135 | $13M | 2.0% | 2026-Q2 |
| FMR LLC trimmed | 776,462 | $11M | 1.8% | 2026-Q2 |
| MORGAN STANLEY added | 765,425 | $11M | 1.8% | 2026-Q2 |
| STATE STREET CORP added | 736,221 | $11M | 1.7% | 2026-Q2 |
| Woodline Partners LP trimmed | 700,354 | $10M | 1.6% | 2026-Q2 |
| DIMENSIONAL FUND ADVISORS LP added | 694,743 | $10M | 1.6% | 2026-Q2 |
| GOLDMAN SACHS GROUP INC added | 656,584 | $10M | 1.5% | 2026-Q2 |
| JACOBS LEVY EQUITY MANAGEMENT, INC added | 565,597 | $8M | 1.3% | 2026-Q2 |
| Siren, L.L.C. new | 523,212 | $8M | 1.2% | 2026-Q2 |
| Qube Research & Technologies Ltd added | 437,079 | $6M | 1.0% | 2026-Q2 |
| RENAISSANCE TECHNOLOGIES LLC trimmed | 387,913 | $6M | 0.9% | 2026-Q2 |
| KENNEDY CAPITAL MANAGEMENT LLC added | 384,036 | $6M | 0.9% | 2026-Q2 |
| NORTHERN TRUST CORP added | 353,197 | $5M | 0.8% | 2026-Q2 |
| ALGERT GLOBAL LLC added | 296,085 | $4M | 0.7% | 2026-Q2 |
| ACUTA CAPITAL PARTNERS, LLC added | 282,564 | $4M | 0.7% | 2026-Q2 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC added | 271,264 | $4M | 0.6% | 2026-Q2 |
| VANGUARD PORTFOLIO MANAGEMENT LLC added | 251,442 | $4M | 0.6% | 2026-Q2 |
| VANGUARD FIDUCIARY TRUST CO added | 230,202 | $3M | 0.5% | 2026-Q2 |
| PRUDENTIAL FINANCIAL INC added | 224,170 | $3M | 0.5% | 2026-Q2 |
| D. E. Shaw & Co., Inc. trimmed | 195,645 | $3M | 0.5% | 2026-Q2 |
| Eversept Partners, LP new | 190,000 | $3M | 0.4% | 2026-Q2 |
| KVP Capital Advisors, LP new | 185,000 | $3M | 0.4% | 2026-Q2 |
| J. Goldman & Co LP new | 176,770 | $3M | 0.4% | 2026-Q2 |
| MILLENNIUM MANAGEMENT LLC added | 147,714 | $2M | 0.3% | 2026-Q2 |
| RAYMOND JAMES FINANCIAL INC added | 138,521 | $2M | 0.3% | 2026-Q2 |
| BALYASNY ASSET MANAGEMENT L.P. new | 111,103 | $2M | 0.3% | 2026-Q2 |
| Elmind Capital, LP trimmed | 107,900 | $2M | 0.3% | 2026-Q2 |
| Nuveen, LLC trimmed | 104,734 | $2M | 0.2% | 2026-Q2 |
| DAFNA Capital Management LLC new | 102,600 | $1M | 0.2% | 2026-Q2 |
| Bank of New York Mellon Corp added | 92,069 | $1M | 0.2% | 2026-Q2 |
| China Universal Asset Management Co., Ltd. added | 89,940 | $1M | 0.2% | 2026-Q2 |
| CITADEL ADVISORS LLC trimmed | 81,971 | $1M | 0.2% | 2026-Q2 |
| SummitTX Capital, L.P. new | 80,663 | $1M | 0.2% | 2026-Q2 |
| AMERICAN CENTURY COMPANIES INC added | 76,825 | $1M | 0.2% | 2026-Q2 |
| Palumbo Wealth Management LLC added | 71,744 | $1M | 0.2% | 2026-Q2 |
| AQR CAPITAL MANAGEMENT LLC added | 71,114 | $1M | 0.2% | 2026-Q2 |
| AMERIPRISE FINANCIAL INC added | 67,598 | $978K | 0.2% | 2026-Q2 |
| Russell Investments Group, Ltd. added | 66,859 | $967K | 0.2% | 2026-Q2 |
| ALPS ADVISORS INC added | 63,391 | $917K | 0.1% | 2026-Q2 |
| STATE OF WISCONSIN INVESTMENT BOARD added | 59,249 | $857K | 0.1% | 2026-Q2 |
| STRS OHIO added | 50,500 | $731K | 0.1% | 2026-Q2 |
| Verdad Advisers, LP trimmed | 47,557 | $688K | 0.1% | 2026-Q2 |
| BANK OF AMERICA CORP /DE/ added | 43,728 | $633K | 0.1% | 2026-Q2 |
| ALLIANCEBERNSTEIN L.P. trimmed | 43,230 | $460K | 0.1% | 2026-Q2 |
| ExodusPoint Capital Management, LP new | 41,286 | $597K | 0.1% | 2026-Q2 |
| RHUMBLINE ADVISERS added | 38,132 | $552K | 0.1% | 2026-Q2 |
| Vanguard Global Advisers, LLC added | 35,534 | $514K | 0.1% | 2026-Q2 |
| UBS Group AG added | 34,761 | $503K | 0.1% | 2026-Q2 |
| Susquehanna Portfolio Strategies, LLC new | 33,375 | $483K | 0.1% | 2026-Q2 |
| TWO SIGMA INVESTMENTS, LP added | 32,925 | $476K | 0.1% | 2026-Q2 |
| CANADA PENSION PLAN INVESTMENT BOARD trimmed | 32,600 | $472K | 0.1% | 2026-Q2 |
| OPPENHEIMER & CO INC new | 32,087 | $464K | 0.1% | 2026-Q2 |
| DEUTSCHE BANK AG\ added | 30,613 | $443K | 0.1% | 2026-Q2 |
| Virtus Investment Advisers, LLC new | 29,827 | $432K | 0.1% | 2026-Q2 |
| Squarepoint Ops LLC trimmed | 29,630 | $429K | 0.1% | 2026-Q2 |
| Trexquant Investment LP trimmed | 28,150 | $407K | 0.1% | 2026-Q2 |
| WELLS FARGO & COMPANY/MN added | 28,072 | $406K | 0.1% | 2026-Q2 |
| Corient Private Wealth LP | 27,169 | $393K | 0.1% | 2026-Q2 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC trimmed | 27,000 | $391K | 0.1% | 2026-Q2 |
| Quantinno Capital Management LP added | 26,901 | $389K | 0.1% | 2026-Q2 |
| PRICE T ROWE ASSOCIATES INC /MD/ added | 25,606 | $371K | 0.1% | 2026-Q2 |
| SEI INVESTMENTS CO trimmed | 22,740 | $329K | 0.1% | 2026-Q2 |
| XTX Topco Ltd trimmed | 22,383 | $324K | 0.1% | 2026-Q2 |
| AlphaCentric Advisors LLC added | 21,537 | $312K | 0.1% | 2026-Q2 |
| Invesco Ltd. trimmed | 21,429 | $310K | 0.1% | 2026-Q2 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO added | 20,700 | $300K | 0.0% | 2026-Q2 |
| MetLife Investment Management, LLC added | 20,609 | $298K | 0.0% | 2026-Q2 |
| WELLINGTON MANAGEMENT GROUP LLP trimmed | 19,400 | $281K | 0.0% | 2026-Q2 |
| JPMORGAN CHASE & CO added | 16,904 | $241K | 0.0% | 2026-Q2 |
| CITIGROUP INC added | 15,880 | $230K | 0.0% | 2026-Q2 |
| Creative Planning new | 15,844 | $229K | 0.0% | 2026-Q2 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP trimmed | 15,650 | $226K | 0.0% | 2026-Q2 |
| NISA INVESTMENT ADVISORS, LLC | 14,824 | $215K | 0.0% | 2026-Q2 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. added | 14,171 | $205K | 0.0% | 2026-Q2 |
| Y-Intercept (Hong Kong) Ltd new | 12,910 | $187K | 0.0% | 2026-Q2 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC new | 12,553 | $182K | 0.0% | 2026-Q2 |
| ROYAL BANK OF CANADA added | 12,254 | $178K | 0.0% | 2026-Q2 |
| BARCLAYS PLC trimmed | 11,707 | $169K | 0.0% | 2026-Q2 |
| NEW YORK STATE COMMON RETIREMENT FUND added | 10,826 | $157K | 0.0% | 2026-Q2 |
| Police & Firemen's Retirement System of New Jersey added | 9,849 | $143K | 0.0% | 2026-Q2 |
| BNP PARIBAS FINANCIAL MARKETS trimmed | 5,751 | $83K | 0.0% | 2026-Q2 |
| Clearstead Advisors, LLC added | 5,610 | $81K | 0.0% | 2026-Q2 |
| Tower Research Capital LLC (TRC) added | 4,908 | $71K | 0.0% | 2026-Q2 |
| Rockefeller Capital Management L.P. | 3,684 | $53K | 0.0% | 2026-Q2 |
| CAZ INVESTMENTS LP | 3,500 | $51K | 0.0% | 2026-Q2 |
| Zurcher Kantonalbank (Zurich Cantonalbank) added | 3,025 | $44K | 0.0% | 2026-Q2 |
| Legal & General Group Plc added | 2,987 | $43K | 0.0% | 2026-Q2 |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.