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Institutional Ownership · SEC Form 13F

Who owns Denali Therapeutics Inc. (DNLI)


Which tracked institutional funds hold DNLI, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See DNLI company fundamentals →

Ownership as of the 2026-Q1 13F filings. 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.

268
Institutional holders
151M
Shares held (tracked funds)
96.4%
Of shares outstanding

How the tape is positioned

98 tracked funds added or opened DNLI while 42 trimmed or exited it between 2025-Q4 and 2026-Q1 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.

A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.

Conviction spread

DNLI’s largest tracked holder by dollar value, BlackRock, Inc., sizes it at 0.0% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 0.0pp gap the other way — the median holder sizes DNLI more heavily than its largest holder by dollar value does.

Book-share is each fund’s reported value in DNLI divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.

Institutional & insider positioning

Between 2025-Q4 and 2026-Q1, across 268 tracked filers holding DNLI, 158 increased or opened the position and 94 reduced or closed it; over the same quarter, open-market insider Form 4 buying and selling roughly offset.

This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.

New buyers & exits

Funds opening or closing a position in DNLI between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.

New buyers 20

  • VANGUARD CAPITAL MANAGEMENT LLC$118M
  • VANGUARD PORTFOLIO MANAGEMENT LLC$118M
  • Artisan Partners Limited Partnership$21M
  • VANGUARD FIDUCIARY TRUST CO$18M
  • Clearstead Advisors, LLC$14M
  • BRAIDWELL LP$6M

Full exits 19

  • VANGUARD GROUP INC$197M
  • ExodusPoint Capital Management, LP$17M
  • VOLORIDGE INVESTMENT MANAGEMENT, LLC$10M
  • Qube Research & Technologies Ltd$10M
  • TWO SIGMA INVESTMENTS, LP$7M
  • Clarius Group, LLC$6M

Largest adds

  • T. Rowe Price Investment Management, Inc.$143M
  • BlackRock, Inc.$40M
  • ADAR1 Capital Management, LLC$35M
  • BAILLIE GIFFORD & CO$28M
  • Pictet Asset Management Holding SA$26M
  • Vestal Point Capital, LP$26M

Largest trims

  • NORGES BANK$43M
  • Point72 Asset Management, L.P.$27M
  • PRICE T ROWE ASSOCIATES INC /MD/$17M
  • Capital Research Global Investors$13M
  • FMR LLC$13M
  • ALLIANCEBERNSTEIN L.P.$11M

Institutional holders

One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).

FundSharesReported value% of valueQuarter
BlackRock, Inc. added13,034,434$250M8.2%2026-Q1
BAILLIE GIFFORD & CO trimmed12,066,479$232M7.5%2026-Q1
T. Rowe Price Investment Management, Inc. added8,519,192$164M5.3%2026-Q1
Temasek Holdings (Private) Ltd7,012,974$135M4.4%2026-Q1
STATE STREET CORP added6,272,001$120M3.9%2026-Q1
VANGUARD CAPITAL MANAGEMENT LLC new6,147,957$118M3.8%2026-Q1
VANGUARD PORTFOLIO MANAGEMENT LLC new6,120,160$118M3.8%2026-Q1
FMR LLC trimmed4,560,585$88M2.9%2026-Q1
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC trimmed4,432,314$85M2.8%2026-Q1
GOLDMAN SACHS GROUP INC added4,407,255$85M2.8%2026-Q1
BAKER BROS. ADVISORS LP3,731,695$72M2.3%2026-Q1
GEODE CAPITAL MANAGEMENT, LLC added3,727,114$72M2.3%2026-Q1
Holocene Advisors, LP added3,195,429$61M2.0%2026-Q1
DIMENSIONAL FUND ADVISORS LP added2,692,175$52M1.7%2026-Q1
UBS Group AG added2,571,344$49M1.6%2026-Q1
Pictet Asset Management Holding SA added2,558,865$48M1.6%2026-Q1
Capital Research Global Investors trimmed2,514,588$48M1.6%2026-Q1
ALLIANCEBERNSTEIN L.P. trimmed2,893,618$48M1.6%2026-Q1
PRICE T ROWE ASSOCIATES INC /MD/ trimmed2,464,146$47M1.5%2026-Q1
Fisher Asset Management, LLC trimmed2,436,895$47M1.5%2026-Q1
Crestline Management, L.P. trimmed2,210,732$42M1.4%2026-Q1
NORGES BANK trimmed3,047,606$41M1.3%2026-Q1
Alyeska Investment Group, L.P. added1,941,123$37M1.2%2026-Q1
Lynx1 Capital Management LP added1,880,303$36M1.2%2026-Q1
ADAR1 Capital Management, LLC added1,871,455$36M1.2%2026-Q1
Aberdeen Group plc trimmed1,854,446$36M1.2%2026-Q1
Casdin Capital, LLC1,840,000$35M1.2%2026-Q1
Vestal Point Capital, LP added1,773,326$34M1.1%2026-Q1
PRINCIPAL FINANCIAL GROUP INC trimmed1,478,486$28M0.9%2026-Q1
Siren, L.L.C.1,396,513$27M0.9%2026-Q1
Defilade Capital Management, L.P. added1,359,969$26M0.9%2026-Q1
NORTHERN TRUST CORP added1,310,656$25M0.8%2026-Q1
MILLENNIUM MANAGEMENT LLC added1,257,950$24M0.8%2026-Q1
Foresite Capital Management VI LLC added1,209,971$23M0.8%2026-Q1
CHARLES SCHWAB INVESTMENT MANAGEMENT INC added1,207,399$23M0.8%2026-Q1
BANK OF AMERICA CORP /DE/ added1,134,183$22M0.7%2026-Q1
MORGAN STANLEY trimmed1,104,757$21M0.7%2026-Q1
Candriam S.C.A. trimmed1,099,845$21M0.7%2026-Q1
Artisan Partners Limited Partnership added1,099,719$21M0.7%2026-Q1
MARSHALL WACE, LLP added991,268$19M0.6%2026-Q1
VANGUARD FIDUCIARY TRUST CO new949,695$18M0.6%2026-Q1
AMERICAN CENTURY COMPANIES INC added935,692$18M0.6%2026-Q1
Bank of New York Mellon Corp added768,039$15M0.5%2026-Q1
Clearstead Advisors, LLC new737,990$14M0.5%2026-Q1
Cercano Management LLC625,000$12M0.4%2026-Q1
MASTERS CAPITAL MANAGEMENT LLC trimmed600,000$12M0.4%2026-Q1
SEGALL BRYANT & HAMILL, LLC trimmed519,600$11M0.4%2026-Q1
Ensign Peak Advisors, Inc515,721$10M0.3%2026-Q1
STEMPOINT CAPITAL LP added426,561$8M0.3%2026-Q1
Woodline Partners LP added364,082$7M0.2%2026-Q1
Hudson Bay Capital Management LP trimmed346,360$7M0.2%2026-Q1
DAFNA Capital Management LLC318,500$6M0.2%2026-Q1
Invesco Ltd. added310,196$6M0.2%2026-Q1
JPMORGAN CHASE & CO added323,989$6M0.2%2026-Q1
BNP PARIBAS ASSET MANAGEMENT Holding S.A. trimmed296,503$6M0.2%2026-Q1
BRAIDWELL LP trimmed296,324$6M0.2%2026-Q1
Nuveen, LLC added295,586$6M0.2%2026-Q1
Marex Group plc trimmed287,000$6M0.2%2026-Q1
Swiss National Bank273,800$5M0.2%2026-Q1
SCHRODER INVESTMENT MANAGEMENT GROUP trimmed285,820$5M0.2%2026-Q1
TD Asset Management Inc trimmed255,766$5M0.2%2026-Q1
Privium Fund Management B.V. new254,857$5M0.2%2026-Q1
Palo Alto Investors LP trimmed234,582$5M0.1%2026-Q1
GREAT LAKES ADVISORS, LLC new227,110$4M0.1%2026-Q1
EDMOND DE ROTHSCHILD HOLDING S.A.225,680$4M0.1%2026-Q1
GROUPAMA ASSET MANAGMENT added207,130$4M0.1%2026-Q1
Burkehill Global Management, LP200,000$4M0.1%2026-Q1
Rhenman & Partners Asset Management AB added199,000$4M0.1%2026-Q1
SCS Capital Management LLC197,998$4M0.1%2026-Q1
BALYASNY ASSET MANAGEMENT L.P. added195,108$4M0.1%2026-Q1
RHUMBLINE ADVISERS added184,248$4M0.1%2026-Q1
CITADEL ADVISORS LLC trimmed181,417$3M0.1%2026-Q1
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY added166,181$3M0.1%2026-Q1
SECTOR GAMMA AS new162,710$3M0.1%2026-Q1
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM added162,576$3M0.1%2026-Q1
Susquehanna Portfolio Strategies, LLC trimmed157,896$3M0.1%2026-Q1
Rafferty Asset Management, LLC trimmed150,687$3M0.1%2026-Q1
Man Group plc added139,045$3M0.1%2026-Q1
ALPS ADVISORS INC added129,105$2M0.1%2026-Q1
NEW YORK STATE COMMON RETIREMENT FUND added128,119$2M0.1%2026-Q1
MANUFACTURERS LIFE INSURANCE COMPANY, THE trimmed125,442$2M0.1%2026-Q1
VANGUARD ASSET MANAGEMENT, Ltd new125,243$2M0.1%2026-Q1
VANGUARD GROUP INC trimmed11,904,207$197M6.4%2025-Q4 stale
ExodusPoint Capital Management, LP added1,023,253$17M0.6%2025-Q4 stale
VOLORIDGE INVESTMENT MANAGEMENT, LLC trimmed591,461$10M0.3%2025-Q4 stale
Qube Research & Technologies Ltd added590,314$10M0.3%2025-Q4 stale
TWO SIGMA INVESTMENTS, LP added430,177$7M0.2%2025-Q4 stale
Yiheng Capital Management, L.P.469,981$7M0.2%2025-Q3 stale
Clarius Group, LLC added368,995$6M0.2%2025-Q4 stale
Camber Capital Management LP trimmed400,000$6M0.2%2025-Q2 stale
Pier Capital, LLC trimmed301,171$4M0.1%2025-Q3 stale
AXA Investment Managers S.A. new294,732$4M0.1%2025-Q3 stale
AXA S.A. added293,853$4M0.1%2025-Q2 stale
Boxer Capital Management, LLC250,000$4M0.1%2025-Q3 stale
Trexquant Investment LP trimmed209,609$3M0.1%2025-Q4 stale
Cubist Systematic Strategies, LLC trimmed230,968$3M0.1%2025-Q3 stale
Schonfeld Strategic Advisors LLC added226,203$3M0.1%2025-Q3 stale
Campbell & CO Investment Adviser LLC added216,774$3M0.1%2025-Q3 stale
TWO SIGMA ADVISERS, LP added154,800$3M0.1%2025-Q4 stale
Soleus Capital Management, L.P. added182,110$3M0.1%2025-Q2 stale

Ownership over time

Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.

HoldersTotal shares

Reading this table

Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.

About 13F filings

A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.

Learn how to read institutional ownership