Who owns Denali Therapeutics Inc. (DNLI)
Which tracked institutional funds hold DNLI, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See DNLI company fundamentals →
Ownership as of the 2026-Q1 13F filings. 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.
How the tape is positioned
98 tracked funds added or opened DNLI while 42 trimmed or exited it between 2025-Q4 and 2026-Q1 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.
A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.
Conviction spread
DNLI’s largest tracked holder by dollar value, BlackRock, Inc., sizes it at 0.0% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 0.0pp gap the other way — the median holder sizes DNLI more heavily than its largest holder by dollar value does.
Book-share is each fund’s reported value in DNLI divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.
Institutional & insider positioning
Between 2025-Q4 and 2026-Q1, across 268 tracked filers holding DNLI, 158 increased or opened the position and 94 reduced or closed it; over the same quarter, open-market insider Form 4 buying and selling roughly offset.
This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.
New buyers & exits
Funds opening or closing a position in DNLI between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.
New buyers 20
- VANGUARD CAPITAL MANAGEMENT LLC$118M
- VANGUARD PORTFOLIO MANAGEMENT LLC$118M
- Artisan Partners Limited Partnership$21M
- VANGUARD FIDUCIARY TRUST CO$18M
- Clearstead Advisors, LLC$14M
- BRAIDWELL LP$6M
Full exits 19
- VANGUARD GROUP INC$197M
- ExodusPoint Capital Management, LP$17M
- VOLORIDGE INVESTMENT MANAGEMENT, LLC$10M
- Qube Research & Technologies Ltd$10M
- TWO SIGMA INVESTMENTS, LP$7M
- Clarius Group, LLC$6M
Largest adds
- T. Rowe Price Investment Management, Inc.$143M
- BlackRock, Inc.$40M
- ADAR1 Capital Management, LLC$35M
- BAILLIE GIFFORD & CO$28M
- Pictet Asset Management Holding SA$26M
- Vestal Point Capital, LP$26M
Largest trims
- NORGES BANK$43M
- Point72 Asset Management, L.P.$27M
- PRICE T ROWE ASSOCIATES INC /MD/$17M
- Capital Research Global Investors$13M
- FMR LLC$13M
- ALLIANCEBERNSTEIN L.P.$11M
Institutional holders
One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).
| Fund | Shares | Reported value | % of value | Quarter |
|---|---|---|---|---|
| BlackRock, Inc. added | 13,034,434 | $250M | 8.2% | 2026-Q1 |
| BAILLIE GIFFORD & CO trimmed | 12,066,479 | $232M | 7.5% | 2026-Q1 |
| T. Rowe Price Investment Management, Inc. added | 8,519,192 | $164M | 5.3% | 2026-Q1 |
| Temasek Holdings (Private) Ltd | 7,012,974 | $135M | 4.4% | 2026-Q1 |
| STATE STREET CORP added | 6,272,001 | $120M | 3.9% | 2026-Q1 |
| VANGUARD CAPITAL MANAGEMENT LLC new | 6,147,957 | $118M | 3.8% | 2026-Q1 |
| VANGUARD PORTFOLIO MANAGEMENT LLC new | 6,120,160 | $118M | 3.8% | 2026-Q1 |
| FMR LLC trimmed | 4,560,585 | $88M | 2.9% | 2026-Q1 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC trimmed | 4,432,314 | $85M | 2.8% | 2026-Q1 |
| GOLDMAN SACHS GROUP INC added | 4,407,255 | $85M | 2.8% | 2026-Q1 |
| BAKER BROS. ADVISORS LP | 3,731,695 | $72M | 2.3% | 2026-Q1 |
| GEODE CAPITAL MANAGEMENT, LLC added | 3,727,114 | $72M | 2.3% | 2026-Q1 |
| Holocene Advisors, LP added | 3,195,429 | $61M | 2.0% | 2026-Q1 |
| DIMENSIONAL FUND ADVISORS LP added | 2,692,175 | $52M | 1.7% | 2026-Q1 |
| UBS Group AG added | 2,571,344 | $49M | 1.6% | 2026-Q1 |
| Pictet Asset Management Holding SA added | 2,558,865 | $48M | 1.6% | 2026-Q1 |
| Capital Research Global Investors trimmed | 2,514,588 | $48M | 1.6% | 2026-Q1 |
| ALLIANCEBERNSTEIN L.P. trimmed | 2,893,618 | $48M | 1.6% | 2026-Q1 |
| PRICE T ROWE ASSOCIATES INC /MD/ trimmed | 2,464,146 | $47M | 1.5% | 2026-Q1 |
| Fisher Asset Management, LLC trimmed | 2,436,895 | $47M | 1.5% | 2026-Q1 |
| Crestline Management, L.P. trimmed | 2,210,732 | $42M | 1.4% | 2026-Q1 |
| NORGES BANK trimmed | 3,047,606 | $41M | 1.3% | 2026-Q1 |
| Alyeska Investment Group, L.P. added | 1,941,123 | $37M | 1.2% | 2026-Q1 |
| Lynx1 Capital Management LP added | 1,880,303 | $36M | 1.2% | 2026-Q1 |
| ADAR1 Capital Management, LLC added | 1,871,455 | $36M | 1.2% | 2026-Q1 |
| Aberdeen Group plc trimmed | 1,854,446 | $36M | 1.2% | 2026-Q1 |
| Casdin Capital, LLC | 1,840,000 | $35M | 1.2% | 2026-Q1 |
| Vestal Point Capital, LP added | 1,773,326 | $34M | 1.1% | 2026-Q1 |
| PRINCIPAL FINANCIAL GROUP INC trimmed | 1,478,486 | $28M | 0.9% | 2026-Q1 |
| Siren, L.L.C. | 1,396,513 | $27M | 0.9% | 2026-Q1 |
| Defilade Capital Management, L.P. added | 1,359,969 | $26M | 0.9% | 2026-Q1 |
| NORTHERN TRUST CORP added | 1,310,656 | $25M | 0.8% | 2026-Q1 |
| MILLENNIUM MANAGEMENT LLC added | 1,257,950 | $24M | 0.8% | 2026-Q1 |
| Foresite Capital Management VI LLC added | 1,209,971 | $23M | 0.8% | 2026-Q1 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC added | 1,207,399 | $23M | 0.8% | 2026-Q1 |
| BANK OF AMERICA CORP /DE/ added | 1,134,183 | $22M | 0.7% | 2026-Q1 |
| MORGAN STANLEY trimmed | 1,104,757 | $21M | 0.7% | 2026-Q1 |
| Candriam S.C.A. trimmed | 1,099,845 | $21M | 0.7% | 2026-Q1 |
| Artisan Partners Limited Partnership added | 1,099,719 | $21M | 0.7% | 2026-Q1 |
| MARSHALL WACE, LLP added | 991,268 | $19M | 0.6% | 2026-Q1 |
| VANGUARD FIDUCIARY TRUST CO new | 949,695 | $18M | 0.6% | 2026-Q1 |
| AMERICAN CENTURY COMPANIES INC added | 935,692 | $18M | 0.6% | 2026-Q1 |
| Bank of New York Mellon Corp added | 768,039 | $15M | 0.5% | 2026-Q1 |
| Clearstead Advisors, LLC new | 737,990 | $14M | 0.5% | 2026-Q1 |
| Cercano Management LLC | 625,000 | $12M | 0.4% | 2026-Q1 |
| MASTERS CAPITAL MANAGEMENT LLC trimmed | 600,000 | $12M | 0.4% | 2026-Q1 |
| SEGALL BRYANT & HAMILL, LLC trimmed | 519,600 | $11M | 0.4% | 2026-Q1 |
| Ensign Peak Advisors, Inc | 515,721 | $10M | 0.3% | 2026-Q1 |
| STEMPOINT CAPITAL LP added | 426,561 | $8M | 0.3% | 2026-Q1 |
| Woodline Partners LP added | 364,082 | $7M | 0.2% | 2026-Q1 |
| Hudson Bay Capital Management LP trimmed | 346,360 | $7M | 0.2% | 2026-Q1 |
| DAFNA Capital Management LLC | 318,500 | $6M | 0.2% | 2026-Q1 |
| Invesco Ltd. added | 310,196 | $6M | 0.2% | 2026-Q1 |
| JPMORGAN CHASE & CO added | 323,989 | $6M | 0.2% | 2026-Q1 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. trimmed | 296,503 | $6M | 0.2% | 2026-Q1 |
| BRAIDWELL LP trimmed | 296,324 | $6M | 0.2% | 2026-Q1 |
| Nuveen, LLC added | 295,586 | $6M | 0.2% | 2026-Q1 |
| Marex Group plc trimmed | 287,000 | $6M | 0.2% | 2026-Q1 |
| Swiss National Bank | 273,800 | $5M | 0.2% | 2026-Q1 |
| SCHRODER INVESTMENT MANAGEMENT GROUP trimmed | 285,820 | $5M | 0.2% | 2026-Q1 |
| TD Asset Management Inc trimmed | 255,766 | $5M | 0.2% | 2026-Q1 |
| Privium Fund Management B.V. new | 254,857 | $5M | 0.2% | 2026-Q1 |
| Palo Alto Investors LP trimmed | 234,582 | $5M | 0.1% | 2026-Q1 |
| GREAT LAKES ADVISORS, LLC new | 227,110 | $4M | 0.1% | 2026-Q1 |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 225,680 | $4M | 0.1% | 2026-Q1 |
| GROUPAMA ASSET MANAGMENT added | 207,130 | $4M | 0.1% | 2026-Q1 |
| Burkehill Global Management, LP | 200,000 | $4M | 0.1% | 2026-Q1 |
| Rhenman & Partners Asset Management AB added | 199,000 | $4M | 0.1% | 2026-Q1 |
| SCS Capital Management LLC | 197,998 | $4M | 0.1% | 2026-Q1 |
| BALYASNY ASSET MANAGEMENT L.P. added | 195,108 | $4M | 0.1% | 2026-Q1 |
| RHUMBLINE ADVISERS added | 184,248 | $4M | 0.1% | 2026-Q1 |
| CITADEL ADVISORS LLC trimmed | 181,417 | $3M | 0.1% | 2026-Q1 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY added | 166,181 | $3M | 0.1% | 2026-Q1 |
| SECTOR GAMMA AS new | 162,710 | $3M | 0.1% | 2026-Q1 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM added | 162,576 | $3M | 0.1% | 2026-Q1 |
| Susquehanna Portfolio Strategies, LLC trimmed | 157,896 | $3M | 0.1% | 2026-Q1 |
| Rafferty Asset Management, LLC trimmed | 150,687 | $3M | 0.1% | 2026-Q1 |
| Man Group plc added | 139,045 | $3M | 0.1% | 2026-Q1 |
| ALPS ADVISORS INC added | 129,105 | $2M | 0.1% | 2026-Q1 |
| NEW YORK STATE COMMON RETIREMENT FUND added | 128,119 | $2M | 0.1% | 2026-Q1 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE trimmed | 125,442 | $2M | 0.1% | 2026-Q1 |
| VANGUARD ASSET MANAGEMENT, Ltd new | 125,243 | $2M | 0.1% | 2026-Q1 |
| VANGUARD GROUP INC trimmed | 11,904,207 | $197M | 6.4% | 2025-Q4 stale |
| ExodusPoint Capital Management, LP added | 1,023,253 | $17M | 0.6% | 2025-Q4 stale |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC trimmed | 591,461 | $10M | 0.3% | 2025-Q4 stale |
| Qube Research & Technologies Ltd added | 590,314 | $10M | 0.3% | 2025-Q4 stale |
| TWO SIGMA INVESTMENTS, LP added | 430,177 | $7M | 0.2% | 2025-Q4 stale |
| Yiheng Capital Management, L.P. | 469,981 | $7M | 0.2% | 2025-Q3 stale |
| Clarius Group, LLC added | 368,995 | $6M | 0.2% | 2025-Q4 stale |
| Camber Capital Management LP trimmed | 400,000 | $6M | 0.2% | 2025-Q2 stale |
| Pier Capital, LLC trimmed | 301,171 | $4M | 0.1% | 2025-Q3 stale |
| AXA Investment Managers S.A. new | 294,732 | $4M | 0.1% | 2025-Q3 stale |
| AXA S.A. added | 293,853 | $4M | 0.1% | 2025-Q2 stale |
| Boxer Capital Management, LLC | 250,000 | $4M | 0.1% | 2025-Q3 stale |
| Trexquant Investment LP trimmed | 209,609 | $3M | 0.1% | 2025-Q4 stale |
| Cubist Systematic Strategies, LLC trimmed | 230,968 | $3M | 0.1% | 2025-Q3 stale |
| Schonfeld Strategic Advisors LLC added | 226,203 | $3M | 0.1% | 2025-Q3 stale |
| Campbell & CO Investment Adviser LLC added | 216,774 | $3M | 0.1% | 2025-Q3 stale |
| TWO SIGMA ADVISERS, LP added | 154,800 | $3M | 0.1% | 2025-Q4 stale |
| Soleus Capital Management, L.P. added | 182,110 | $3M | 0.1% | 2025-Q2 stale |
Ownership over time
Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.
Reading this table
Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.
About 13F filings
A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.