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Institutional Ownership · SEC Form 13F

Who owns ANNX (ANNX)


Which tracked institutional funds hold ANNX, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See ANNX company fundamentals →

Ownership as of the 2026-Q1 13F filings. 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.

217
Institutional holders
154,960,043
Shares held (tracked funds)

How the tape is positioned

61 tracked funds added or opened ANNX while 31 trimmed or exited it between 2025-Q4 and 2026-Q1 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.

A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.

Conviction spread

ANNX’s largest tracked holder by dollar value, Redmile Group, LLC, sizes it at 5.3% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 5.3pp conviction gap — its largest holder concentrates the name more heavily than the typical one.

Book-share is each fund’s reported value in ANNX divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.

Institutional & insider positioning

Between 2025-Q4 and 2026-Q1, across 217 tracked filers holding ANNX, 150 increased or opened the position and 69 reduced or closed it; over the same quarter, open-market insider Form 4s were net purchases.

This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.

New buyers & exits

Funds opening or closing a position in ANNX between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.

New buyers 18

  • VANGUARD CAPITAL MANAGEMENT LLC$33M
  • Siren, L.L.C.$22M
  • GREAT POINT PARTNERS LLC$14M
  • VANGUARD PORTFOLIO MANAGEMENT LLC$8M
  • Y-Intercept (Hong Kong) Ltd$7M
  • VANGUARD FIDUCIARY TRUST CO$5M

Full exits 5

  • VANGUARD GROUP INC$34M
  • SPHERA FUNDS MANAGEMENT LTD.$7M
  • SummitTX Capital, L.P.$2M
  • Jump Financial, LLC$617K
  • Caption Management, LLC$600K

Largest adds

  • Redmile Group, LLC$30M
  • BlackRock, Inc.$16M
  • BANK OF AMERICA CORP /DE/$16M
  • STATE STREET CORP$15M
  • MAK CAPITAL ONE LLC$11M
  • Nuveen, LLC$9M

Largest trims

  • Longaeva Partners L.P.$12M
  • MILLENNIUM MANAGEMENT LLC$7M
  • Woodline Partners LP$7M
  • J. Goldman & Co LP$4M
  • ADAGE CAPITAL PARTNERS GP, L.L.C.$4M
  • Tetragon Partners GP Ltd$3M

Institutional holders

One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).

FundSharesReported value% of valueQuarter
Redmile Group, LLC added14,549,768$81M8.8%2026-Q1
BlackRock, Inc. added10,938,509$61M6.6%2026-Q1
FMR LLC trimmed9,913,739$55M6.0%2026-Q1
BVF INC/IL trimmed8,698,173$48M5.3%2026-Q1
STATE STREET CORP added6,919,255$38M4.2%2026-Q1
VANGUARD CAPITAL MANAGEMENT LLC new5,956,589$33M3.6%2026-Q1
Bain Capital Life Sciences Investors, LLC trimmed5,212,674$29M3.2%2026-Q1
Bellevue Group AG5,157,290$29M3.1%2026-Q1
MAK CAPITAL ONE LLC added4,724,043$26M2.9%2026-Q1
ADAGE CAPITAL PARTNERS GP, L.L.C. trimmed4,300,000$24M2.6%2026-Q1
BANK OF AMERICA CORP /DE/ added4,259,995$24M2.6%2026-Q1
Nuveen, LLC added4,246,330$24M2.6%2026-Q1
Siren, L.L.C. new3,958,646$22M2.4%2026-Q1
BALYASNY ASSET MANAGEMENT L.P. added3,886,909$22M2.4%2026-Q1
AMERIPRISE FINANCIAL INC trimmed3,449,121$19M2.1%2026-Q1
GEODE CAPITAL MANAGEMENT, LLC added3,377,823$19M2.0%2026-Q1
Qube Research & Technologies Ltd added3,114,314$17M1.9%2026-Q1
Palo Alto Investors LP added2,948,090$16M1.8%2026-Q1
MORGAN STANLEY trimmed2,735,970$15M1.7%2026-Q1
GREAT POINT PARTNERS LLC new2,500,000$14M1.5%2026-Q1
Woodline Partners LP trimmed2,337,137$13M1.4%2026-Q1
Opaleye Management Inc. trimmed2,331,761$13M1.4%2026-Q1
GOLDMAN SACHS GROUP INC added2,152,880$12M1.3%2026-Q1
Point72 Asset Management, L.P. added1,871,795$10M1.1%2026-Q1
VANGUARD PORTFOLIO MANAGEMENT LLC new1,483,090$8M0.9%2026-Q1
Y-Intercept (Hong Kong) Ltd added1,319,913$7M0.8%2026-Q1
Tetragon Partners GP Ltd trimmed1,292,455$7M0.8%2026-Q1
UBS Group AG added1,245,941$7M0.8%2026-Q1
MILLENNIUM MANAGEMENT LLC trimmed1,238,678$7M0.8%2026-Q1
CHARLES SCHWAB INVESTMENT MANAGEMENT INC added1,102,445$6M0.7%2026-Q1
NORTHERN TRUST CORP added1,086,902$6M0.7%2026-Q1
DIMENSIONAL FUND ADVISORS LP added924,078$5M0.6%2026-Q1
KENNEDY CAPITAL MANAGEMENT LLC added912,323$5M0.6%2026-Q1
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ trimmed903,368$5M0.5%2026-Q1
VANGUARD FIDUCIARY TRUST CO new888,552$5M0.5%2026-Q1
MARSHALL WACE, LLP added832,131$5M0.5%2026-Q1
Invesco Ltd. trimmed763,005$4M0.5%2026-Q1
AQR CAPITAL MANAGEMENT LLC trimmed759,556$4M0.5%2026-Q1
ACADIAN ASSET MANAGEMENT LLC trimmed758,232$4M0.5%2026-Q1
Russell Investments Group, Ltd. added711,380$4M0.4%2026-Q1
WELLS FARGO & COMPANY/MN added698,739$4M0.4%2026-Q1
D. E. Shaw & Co., Inc. trimmed678,440$4M0.4%2026-Q1
Parkman Healthcare Partners LLC added674,013$4M0.4%2026-Q1
Ensign Peak Advisors, Inc added625,097$3M0.4%2026-Q1
Longaeva Partners L.P. trimmed620,401$3M0.4%2026-Q1
CITADEL ADVISORS LLC added600,135$3M0.4%2026-Q1
DEERFIELD MANAGEMENT COMPANY, L.P.583,913$3M0.4%2026-Q1
Ikarian Capital, LLC added580,244$3M0.4%2026-Q1
SIRIOS CAPITAL MANAGEMENT L P trimmed575,063$3M0.3%2026-Q1
DEUTSCHE BANK AG\ added562,181$3M0.3%2026-Q1
RENAISSANCE TECHNOLOGIES LLC trimmed544,300$3M0.3%2026-Q1
Hennion & Walsh Asset Management, Inc. trimmed509,689$3M0.3%2026-Q1
SILVERARC CAPITAL MANAGEMENT, LLC added496,461$3M0.3%2026-Q1
Board of Trustees of The Leland Stanford Junior University482,550$3M0.3%2026-Q1
TWO SIGMA INVESTMENTS, LP added471,391$3M0.3%2026-Q1
VOLORIDGE INVESTMENT MANAGEMENT, LLC new462,068$3M0.3%2026-Q1
PRICE T ROWE ASSOCIATES INC /MD/ trimmed428,720$2M0.3%2026-Q1
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC trimmed416,698$2M0.3%2026-Q1
Trexquant Investment LP added403,657$2M0.2%2026-Q1
Bank of New York Mellon Corp added395,019$2M0.2%2026-Q1
Susquehanna Portfolio Strategies, LLC added360,319$2M0.2%2026-Q1
WELLINGTON MANAGEMENT GROUP LLP trimmed325,908$2M0.2%2026-Q1
JPMORGAN CHASE & CO added323,894$2M0.2%2026-Q1
Cinctive Capital Management LP trimmed268,640$1M0.2%2026-Q1
BNP PARIBAS FINANCIAL MARKETS added255,371$1M0.2%2026-Q1
Swiss National Bank added236,000$1M0.1%2026-Q1
Rafferty Asset Management, LLC added203,269$1M0.1%2026-Q1
SEI INVESTMENTS CO added203,236$1M0.1%2026-Q1
Rosalind Advisors, Inc. new200,000$1M0.1%2026-Q1
IEQ CAPITAL, LLC added195,764$1M0.1%2026-Q1
Ishara Investments LP trimmed174,250$965K0.1%2026-Q1
Engineers Gate Manager LP added174,141$965K0.1%2026-Q1
J. Goldman & Co LP trimmed170,817$946K0.1%2026-Q1
BOOTHBAY FUND MANAGEMENT, LLC added166,164$921K0.1%2026-Q1
RHUMBLINE ADVISERS added159,670$885K0.1%2026-Q1
SUSQUEHANNA INTERNATIONAL GROUP, LLP trimmed158,640$879K0.1%2026-Q1
ALGERT GLOBAL LLC added154,840$858K0.1%2026-Q1
JACOBS LEVY EQUITY MANAGEMENT, INC trimmed148,941$825K0.1%2026-Q1
MANUFACTURERS LIFE INSURANCE COMPANY, THE added134,786$747K0.1%2026-Q1
DIADEMA PARTNERS LP trimmed132,916$736K0.1%2026-Q1
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC added130,647$724K0.1%2026-Q1
Schonfeld Strategic Advisors LLC trimmed123,282$683K0.1%2026-Q1
DAFNA Capital Management LLC trimmed117,812$653K0.1%2026-Q1
VICTORY CAPITAL MANAGEMENT INC added115,527$640K0.1%2026-Q1
Man Group plc added109,222$605K0.1%2026-Q1
ALLIANCEBERNSTEIN L.P. trimmed119,050$598K0.1%2026-Q1
SCS Capital Management LLC new99,000$548K0.1%2026-Q1
BRIDGEWAY CAPITAL MANAGEMENT, LLC trimmed97,800$542K0.1%2026-Q1
Connor, Clark & Lunn Investment Management Ltd. trimmed92,707$514K0.1%2026-Q1
VANGUARD GROUP INC added6,855,389$34M3.8%2025-Q4 stale
Sio Capital Management, LLC added4,095,764$10M1.1%2025-Q2 stale
Candriam S.C.A.2,534,230$8M0.8%2025-Q3 stale
SPHERA FUNDS MANAGEMENT LTD. trimmed1,316,212$7M0.7%2025-Q4 stale
Logos Global Management LP trimmed2,410,000$6M0.6%2025-Q2 stale
Rhenman & Partners Asset Management AB added823,000$3M0.3%2025-Q3 stale
SummitTX Capital, L.P. added438,497$2M0.2%2025-Q4 stale
Walleye Capital LLC trimmed794,639$2M0.2%2025-Q2 stale
Point72 Europe (London) LLP added302,861$924K0.1%2025-Q3 stale
Jump Financial, LLC added122,858$617K0.1%2025-Q4 stale
Caption Management, LLC trimmed119,491$600K0.1%2025-Q4 stale

Ownership over time

Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.

HoldersTotal shares

Reading this table

Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.

About 13F filings

A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.

Learn how to read institutional ownership