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Institutional Ownership · SEC Form 13F

Who owns Agios Pharmaceuticals, Inc. (AGIO)


Which tracked institutional funds hold AGIO, how they are positioned, and who is buying versus exiting — from SEC Form 13F-HR filings. See AGIO company fundamentals →

Ownership as of the 2026-Q1 13F filings (latest filed 2026-05-18). 13F is disclosed up to 45 days after quarter-end, so the most recent quarter fills in over the following weeks.

234
Institutional holders
63M
Shares held (tracked funds)

How the tape is positioned

92 tracked funds added or opened AGIO while 51 trimmed or exited it between 2025-Q4 and 2026-Q1 — the tape is split. When large holders disagree on a name, the funds moving first are sometimes ahead of the story.

A prompt to read the filings, not a verdict. 13F is a quarter-end snapshot disclosed up to 45 days late; a fund adds or exits for mandate, benchmark, and timing reasons that have nothing to do with a view on the stock. This is a starting question, not a signal to trade.

Conviction spread

AGIO’s largest tracked holder by dollar value, BlackRock, Inc., sizes it at 0.0% of its own reported 13F book, while the median holder sizes it at 0.0% of theirs — a 0.0pp gap the other way — the median holder sizes AGIO more heavily than its largest holder by dollar value does.

Book-share is each fund’s reported value in AGIO divided by its whole reported 13F book, so it is comparable across funds of different sizes and is unaffected by stock splits. A higher share means a fund has committed more of its book to the name — a starting question about conviction, not a verdict or a signal to trade.

Institutional & insider positioning

Between 2025-Q4 and 2026-Q1, across 234 tracked filers holding AGIO, 118 increased or opened the position and 123 reduced or closed it; over the same quarter, open-market insider Form 4 buying and selling roughly offset.

This fuses two public signals for the same quarter — how tracked institutions changed their positions and whether insiders bought or sold in the open market. It describes what was filed; it is a starting question, not a verdict or a signal to trade.

New buyers & exits

Funds opening or closing a position in AGIO between the 2025-Q4 and 2026-Q1 13F filings, and the largest changes among funds holding it in both. New buyers and exits are counted on fund presence (split-invariant); adds and trims are measured on reported value.

New buyers 18

  • VANGUARD CAPITAL MANAGEMENT LLC$89M
  • VANGUARD PORTFOLIO MANAGEMENT LLC$88M
  • VANGUARD FIDUCIARY TRUST CO$13M
  • ARROWSTREET CAPITAL, LIMITED PARTNERSHIP$8M
  • Schonfeld Strategic Advisors LLC$7M
  • Eversept Partners, LP$7M

Full exits 20

  • VANGUARD GROUP INC$140M
  • TCG Crossover Management, LLC$32M
  • MOORE CAPITAL MANAGEMENT, LP$4M
  • Allianz Asset Management GmbH$4M
  • HighVista Strategies LLC$4M
  • Ikarian Capital, LLC$3M

Largest adds

  • Lynx1 Capital Management LP$86M
  • BlackRock, Inc.$52M
  • FARALLON CAPITAL MANAGEMENT LLC$52M
  • T. Rowe Price Investment Management, Inc.$50M
  • D. E. Shaw & Co., Inc.$41M
  • STATE STREET CORP$29M

Largest trims

  • Capital International Investors$18M
  • BALYASNY ASSET MANAGEMENT L.P.$17M
  • CITADEL ADVISORS LLC$16M
  • MILLENNIUM MANAGEMENT LLC$10M
  • JANE STREET GROUP, LLC$7M
  • PRICE T ROWE ASSOCIATES INC /MD/$7M

Institutional holders

One row per tracked fund, largest reported value first. “% of value” is the fund’s share of this security’s tracked institutional value — not of shares outstanding. Rows marked stale are from an earlier filing than the security’s latest quarter — that fund is absent from the newest snapshot (position exited, or reported under a different name).

FundSharesReported value% of valueQuarter
BlackRock, Inc. added5,754,957$195M6.7%2026-Q1
FARALLON CAPITAL MANAGEMENT LLC added5,684,000$192M6.6%2026-Q1
STATE STREET CORP added3,364,879$114M3.9%2026-Q1
ARMISTICE CAPITAL, LLC trimmed2,716,000$92M3.2%2026-Q1
D. E. Shaw & Co., Inc. added2,681,169$91M3.1%2026-Q1
VANGUARD CAPITAL MANAGEMENT LLC new2,632,316$89M3.1%2026-Q1
Lynx1 Capital Management LP added2,611,568$88M3.1%2026-Q1
VANGUARD PORTFOLIO MANAGEMENT LLC new2,611,035$88M3.1%2026-Q1
Erste Asset Management GmbH trimmed2,704,900$80M2.8%2026-Q1
BNP PARIBAS ASSET MANAGEMENT Holding S.A. added1,580,840$53M1.8%2026-Q1
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. trimmed1,494,435$51M1.7%2026-Q1
T. Rowe Price Investment Management, Inc. added1,488,740$50M1.7%2026-Q1
GEODE CAPITAL MANAGEMENT, LLC added1,467,910$50M1.7%2026-Q1
SUSQUEHANNA INTERNATIONAL GROUP, LLP added1,344,953$45M1.6%2026-Q1
MPM BIOIMPACT LLC added1,306,261$44M1.5%2026-Q1
Frazier Life Sciences Management, L.P. trimmed1,256,080$42M1.5%2026-Q1
GW&K Investment Management, LLC added1,214,901$41M1.4%2026-Q1
DIMENSIONAL FUND ADVISORS LP added1,151,614$39M1.3%2026-Q1
MORGAN STANLEY added967,525$33M1.1%2026-Q1
GOLDMAN SACHS GROUP INC trimmed805,776$27M0.9%2026-Q1
Rock Springs Capital Management LP799,163$27M0.9%2026-Q1
Nuveen, LLC added722,348$24M0.8%2026-Q1
JANE STREET GROUP, LLC trimmed685,240$23M0.8%2026-Q1
CITADEL ADVISORS LLC trimmed619,613$21M0.7%2026-Q1
SCS Capital Management LLC added612,850$21M0.7%2026-Q1
WELLINGTON MANAGEMENT GROUP LLP trimmed587,142$20M0.7%2026-Q1
Foresite Capital Management VI LLC trimmed525,000$18M0.6%2026-Q1
NORTHERN TRUST CORP trimmed509,272$17M0.6%2026-Q1
BANK OF AMERICA CORP /DE/ trimmed507,900$17M0.6%2026-Q1
Artisan Partners Limited Partnership trimmed481,516$16M0.6%2026-Q1
CHARLES SCHWAB INVESTMENT MANAGEMENT INC trimmed477,032$16M0.6%2026-Q1
Connor, Clark & Lunn Investment Management Ltd. trimmed450,093$15M0.5%2026-Q1
Vestal Point Capital, LP added450,000$15M0.5%2026-Q1
MARSHALL WACE, LLP added447,538$15M0.5%2026-Q1
Legal & General Group Plc added423,915$14M0.5%2026-Q1
ArrowMark Colorado Holdings LLC trimmed403,590$14M0.5%2026-Q1
Parkman Healthcare Partners LLC added403,525$14M0.5%2026-Q1
VANGUARD FIDUCIARY TRUST CO new382,021$13M0.4%2026-Q1
BNP PARIBAS FINANCIAL MARKETS added327,457$11M0.4%2026-Q1
PRICE T ROWE ASSOCIATES INC /MD/ trimmed298,783$10M0.3%2026-Q1
KENNEDY CAPITAL MANAGEMENT LLC added275,456$9M0.3%2026-Q1
ALGERT GLOBAL LLC trimmed268,435$9M0.3%2026-Q1
TWO SIGMA INVESTMENTS, LP trimmed251,636$9M0.3%2026-Q1
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP new250,461$8M0.3%2026-Q1
PANAGORA ASSET MANAGEMENT INC added238,468$8M0.3%2026-Q1
Palo Alto Investors LP added213,601$7M0.2%2026-Q1
Seven Fleet Capital Management LP added209,547$7M0.2%2026-Q1
Squarepoint Ops LLC added208,888$7M0.2%2026-Q1
Schonfeld Strategic Advisors LLC added200,061$7M0.2%2026-Q1
Eversept Partners, LP new200,000$7M0.2%2026-Q1
HRT FINANCIAL LP added195,432$7M0.2%2026-Q1
Qube Research & Technologies Ltd trimmed187,667$6M0.2%2026-Q1
Bank of New York Mellon Corp trimmed186,791$6M0.2%2026-Q1
GROUP ONE TRADING LLC added173,279$6M0.2%2026-Q1
Tetragon Partners GP Ltd added164,839$6M0.2%2026-Q1
XTX Topco Ltd added160,880$5M0.2%2026-Q1
Invesco Ltd. added151,430$5M0.2%2026-Q1
Man Group plc added144,297$5M0.2%2026-Q1
Edgestream Partners, L.P. trimmed143,731$5M0.2%2026-Q1
ADAR1 Capital Management, LLC trimmed140,672$5M0.2%2026-Q1
JPMORGAN CHASE & CO trimmed151,558$4M0.2%2026-Q1
UBS Group AG added132,540$4M0.2%2026-Q1
CAPITAL FUND MANAGEMENT S.A. added129,531$4M0.2%2026-Q1
Exome Asset Management LLC trimmed125,060$4M0.1%2026-Q1
AMERICAN CENTURY COMPANIES INC trimmed120,253$4M0.1%2026-Q1
Pictet Asset Management Holding SA trimmed128,814$4M0.1%2026-Q1
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC added110,679$4M0.1%2026-Q1
Swiss National Bank108,860$4M0.1%2026-Q1
ESSEX INVESTMENT MANAGEMENT CO LLC added103,177$3M0.1%2026-Q1
Rafferty Asset Management, LLC trimmed102,741$3M0.1%2026-Q1
TANG CAPITAL MANAGEMENT LLC new100,000$3M0.1%2026-Q1
Bellevue Group AG added3,714,736$149M5.1%2025-Q3 stale
VANGUARD GROUP INC trimmed5,136,492$140M4.8%2025-Q4 stale
Paradigm Biocapital Advisors LP added2,673,555$107M3.7%2025-Q3 stale
Commodore Capital LP added2,338,287$94M3.2%2025-Q3 stale
MACQUARIE GROUP LTD added1,958,101$79M2.7%2025-Q3 stale
Caligan Partners LP added1,131,205$45M1.6%2025-Q3 stale
Fisher Asset Management, LLC trimmed870,145$35M1.2%2025-Q3 stale
TCG Crossover Management, LLC trimmed1,181,841$32M1.1%2025-Q4 stale
ADAGE CAPITAL PARTNERS GP, L.L.C. added800,000$32M1.1%2025-Q3 stale
Polar Capital Holdings Plc added1,002,036$29M1.0%2025-Q1 stale
ORBIMED ADVISORS LLC added557,900$19M0.6%2025-Q2 stale
SummitTX Capital, L.P. added262,977$11M0.4%2025-Q3 stale
Eagle Health Investments LP trimmed246,230$10M0.3%2025-Q3 stale
BAKER BROS. ADVISORS LP189,866$8M0.3%2025-Q3 stale
NORDEA INVESTMENT MANAGEMENT AB added224,746$8M0.3%2025-Q2 stale
AXA S.A. added225,367$7M0.3%2025-Q2 stale
AXA Investment Managers S.A. new177,675$7M0.2%2025-Q3 stale
Cutter Capital Management, LP trimmed235,350$7M0.2%2025-Q1 stale
PEREGRINE CAPITAL MANAGEMENT LLC trimmed162,905$7M0.2%2025-Q3 stale
VOLORIDGE INVESTMENT MANAGEMENT, LLC trimmed187,395$6M0.2%2025-Q2 stale
Alyeska Investment Group, L.P. new146,514$6M0.2%2025-Q3 stale
Patient Square Capital LP trimmed133,827$5M0.2%2025-Q3 stale
CANTOR FITZGERALD, L. P. added134,200$4M0.2%2025-Q2 stale
Walleye Capital LLC trimmed150,511$4M0.2%2025-Q1 stale
MOORE CAPITAL MANAGEMENT, LP added150,000$4M0.1%2025-Q4 stale
Allianz Asset Management GmbH added147,950$4M0.1%2025-Q4 stale
HighVista Strategies LLC trimmed147,662$4M0.1%2025-Q4 stale
Nantahala Capital Management, LLC new100,000$4M0.1%2025-Q3 stale
Casdin Capital, LLC trimmed100,000$3M0.1%2025-Q2 stale

Ownership over time

Tracked institutional holder count and total shares held by filing quarter (independent scales). The curated-era tail and any mid-ingest latest quarter are handled honestly — a partial quarter is not drawn as a collapse.

HoldersTotal shares

Reading this table

Funds hold the same stock for different reasons — an index fund “holds” almost everything, an active manager sizes a name to a mandate and a benchmark, and each fund entered at its own price and time. Because 13F is filed up to 45 days after quarter-end, every row is a backward-looking snapshot; a manager may have traded since. Share-class siblings (a company’s A and C shares) are rolled up to one line so a dual-class name is never double-counted. Compare like-for-like. A large holder is not an endorsement, and a fund exiting is not a warning — this is a starting question, not a verdict.

About 13F filings

A Form 13F is a quarterly disclosure that institutional investment managers with over $100 million in US-listed equities must file with the SEC. In plain English: it is a snapshot of the long stock positions a fund held at the end of a quarter. It covers long US-listed equities only — not short positions, options, cash, or private holdings — and the funds shown are the large sample we track, not the complete 13F universe.

Learn how to read institutional ownership